Modification of Heat-Shock Gene Expression in Drosophila melanogaster Populations via Transposable Elements

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The evolutionary dynamics of repetitive DNA in eukaryotes

1994 • 1,584 citations

Biochemical Evolution

1977 • 1,283 citations

The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis

2000 • 717 citations

PERSPECTIVE: TRANSPOSABLE ELEMENTS, PARASITIC DNA, AND GENOME EVOLUTION

2001 • 566 citations

Hsp70 Prevents Activation of Stress Kinases

1997 • 516 citations

Gene disruptions using P transposable elements: an integral component of the Drosophila genome project.

1995 • 472 citations

Stress and transposable elements: co-evolution or useful parasites?

2000 • 469 citations

Germline Transformation Used to Define Key Features of Heat-Shock Response Elements

1988 • 451 citations

THE POPULATION GENETICS OF DROSOPHILA TRANSPOSABLE ELEMENTS

1989 • 442 citations

Type I repressors of P element mobility.

1993 • 421 citations

RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements

1999 • 348 citations

Deleterious consequences of Hsp70 overexpression in Drosphilla melanogaster larvae

1997 • 318 citations

TARGET SITE SELECTION IN TRANSPOSITION

1997 • 290 citations

It takes two transposons to tango:transposable-element-mediated chromosomal rearrangements

2000 • 287 citations

Effect of EngineeringHsp70Copy Number on Hsp70 Expression and Tolerance of Ecologically Relevant Heat Shock in Larvae and Pupae ofDrosophila Melanogaster

1996 • 222 citations

Induced thermotolerance and associated expression of the heat‐shock protein Hsp70 in adult Drosophila melanogaster

1998 • 206 citations

Hsp70 and larval thermotolerance in Drosophila melanogaster: how much is enough and when is more too much?

1998 • 196 citations

Recombination Rate and the Distribution of Transposable Elements in the Drosophila melanogaster Genome

2002 • 191 citations

DNA sequence requirements for generating paused polymerase at the start of hsp70.

1992 • 188 citations

Invited Review: Interplay between molecular chaperones and signaling pathways in survival of heat shock

2002 • 178 citations

Genomes were forged by massive bombardments with retroelements and retrosequences

2000 • 176 citations

Intracellular localization of heat shock proteins in Drosophila

1980 • 169 citations

REPRODUCTIVE COSTS OF HEAT SHOCK PROTEIN IN TRANSGENIC DROSOPHILA MELANOGASTER

2000 • 160 citations

Natural genetic engineering in evolution

1992 • 139 citations

HSF access to heat shock elements in vivo depends critically on promoter architecture defined by GAGA factor, TFIID, and RNA polymerase II binding sites.

1995 • 131 citations

Transposable elements: possible catalysts of organismic evolution

1995 • 129 citations

EXPERIMENTAL EVOLUTION OF HSP70 EXPRESSION AND THERMOTOLERANCE IN DROSOPHILA MELANOGASTER

1999 • 129 citations

Genetic evidence for adaptation-driven incipient speciation ofDrosophilamelanogasteralong a microclimatic contrast in “Evolution Canyon,” Israel

2001 • 125 citations

A DROSOPHILA MELANOGASTER Strain From Sub-Equatorial Africa Has Exceptional Thermotolerance But Decreased Hsp70 Expression

2001 • 123 citations

Physical map of two D. melanogaster DNA segments containing sequences coding for the 70,000 dalton heat shock protein

1979 • 121 citations

Expression of the Heat-Shock Protein HSP70 in Drosophila Buzzatii Lines Selected for Thermal Resistance

2004 • 118 citations

Dynamics of potentiation and activation: GAGA factor and its role in heat shock gene regulation

1997 • 112 citations

Response To Natural And Laboratory Selection At The Drosophila Hsp70 Genes

2002 • 100 citations

Natural and Genetic Engineering of the Heat-Shock Protein Hsp70 inDrosophila melanogaster: Consequences for Thermotolerance

1998 • 99 citations

Rapid Concerted Evolution via Gene Conversion at the Drosophila hsp70 Genes

2002 • 87 citations

Hsp70 Duplication in the Drosophila melanogaster Species Group: How and When Did Two Become Five?

2001 • 76 citations

Heritability of Expression of the 70KD Heat-Shock Protein in Drosophila melanogaster and Its Relevance to the Evolution of Thermotolerance

1998 • 68 citations

High-resolution mapping of DNase I-hypersensitive sites of Drosophila heat shock genes in Drosophila melanogaster and Saccharomyces cerevisiae.

1984 • 62 citations

Autoregulation of the Heat-Shock Response

1993 • 57 citations

Molecular Architecture of the hsp70 Promoter after Deletion of the TATA Box or the Upstream Regulation Region

1997 • 56 citations

S-element Insertions Are Associated with the Evolution of the Hsp70 Genes in Drosophila melanogaster

2002 • 56 citations

Tissue- and development-specific induction and turnover of hsp70 transcripts from loci 87A and 87C after heat shock and during recovery inDrosophila melanogaster

2002 • 55 citations

Variation in the expression of Hsp70, the major heat-shock protein, and thermotolerance in larval and adult selection lines of Drosophila melanogaster

2000 • 52 citations

Experimental Evolution of Hsp70 Expression and Thermotolerance in Drosophila melanogaster

1999 • 50 citations

Evolutionary implications of a complex pattern of DNA sequence homology extending far upstream of the hsp70 genes at loci 87A7 and 87C1 in Drosophila melanogaster

1982 • 43 citations

Changing fitness consequences of hsp70 copy number in transgenic Drosophila larvae undergoing natural thermal stress

2000 • 42 citations

Cooperative binding of heat shock transcription factor to the Hsp70 promoter in vivo and in vitro.

1994 • 39 citations

Timing and Targeting of P-Element Local Transposition in the Male Germline Cells of Drosophila melanogaster

2002 • 38 citations

Mobile element insertions causing mutations in the Drosophila suppressor of sable locus occur in DNase I hypersensitive subregions of 5'-transcribed nontranslated sequences.

1990 • 30 citations

Evidence for the adaptive significance of an LTR retrotransposon sequence in a Drosophila heterochromatic gene.

2002 • 24 citations

Evolvability of Hsp70 Expression under Artificial Selection for Inducible Thermotolerance in Independent Populations ofDrosophila melanogaster

2002 • 20 citations

Repression of the HSP70B Promoter by NFIL6, Ku70, and MAPK Involves Three Complementary Mechanisms

2001 • 19 citations

Effects of a transposable element insertion on alcohol dehydrogenase expression in Drosophila melanogaster.

1995 • 9 citations

Insertion of the retroposable element,jockey, near theAdhgene ofDrosophila melanogasteris associated with altered gene expression

1996 • 6 citations

A KP element inserted between the two promoters of the alcohol dehydrogenase gene of Drosophila melanogaster differentially affects expression in larvae and adults.

1998 • 6 citations

Deleted Work

1955 • 0 citations