Dynamics of potentiation and activation: GAGA factor and its role in heat shock gene regulation

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1985 • 2,450 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

1987 • 902 citations

The POZ domain: a conserved protein-protein interaction motif.

1994 • 770 citations

ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor

1994 • 662 citations

ACF, an ISWI-Containing and ATP-Utilizing Chromatin Assembly and Remodeling Factor

1997 • 624 citations

Purification and properties of an ATP-dependent nucleosome remodeling factor

1995 • 600 citations

The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes.

1994 • 560 citations

A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation.

1994 • 531 citations

HETEROCHROMATIN AND GENE EXPRESSION IN DROSOPHILA

1995 • 526 citations

GAL4 activates transcription in Drosophila

1988 • 521 citations

Protein traffic on the heat shock promoter: Parking, stalling, and trucking along

1993 • 507 citations

The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila.

1994 • 466 citations

Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts

1988 • 454 citations

Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism.

1991 • 437 citations

The Trithorax-like gene encodes the Drosophila GAGA factor

1994 • 409 citations

Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis

1987 • 382 citations

Sequence-Specific Antirepression of Histone H1-Mediated Inhibition of Basal RNA Polymerase II Transcription

1991 • 378 citations

In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes.

1993 • 361 citations

A General Strategy for Selecting High-Affinity Zinc Finger Proteins for Diverse DNA Target Sites

1997 • 327 citations

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1994 • 325 citations

Position effect variegation and chromatin proteins

1992 • 311 citations

A drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation

1995 • 296 citations

In vitro transcription of the Drosophila engrailed gene.

1988 • 284 citations

The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region.

1992 • 266 citations

Base sequence discrimination by zinc-finger DNA-binding domains

1991 • 261 citations

SELECTED TOPICS IN CHROMATIN STRUCTURE

1985 • 253 citations

(CT)n (GA)n repeats and heat shock elements have distinct roles in chromatin structure and transcriptional activation of the Drosophila hsp26 gene.

1993 • 251 citations

Mechanisms of Heat-Shock Gene Activation in Higher Eukaryotes

1987 • 240 citations

In vivo interactions of RNA polymerase II with genes of Drosophila melanogaster.

1985 • 229 citations

Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseases.

1995 • 223 citations

The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast

1996 • 223 citations

Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation.

1995 • 220 citations

The solution structure of a specific GAGA factor–DNA complex reveals a modular binding mode

1997 • 219 citations

Drosophila Nuclear Proteins Bind to Regions of Alternating C and T Residues in Gene Promoters

1989 • 200 citations

DNA sequence requirements for generating paused polymerase at the start of hsp70.

1992 • 188 citations

A tissue-specific transcription enhancer from the Drosophila yolk protein 1 gene

1986 • 188 citations

The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators.

1993 • 178 citations

Postinitiation Transcriptional Control in Drosophila melanogaster

1990 • 177 citations

The Drosophila GAGA transcription factor is associated with specific regions of heterochromatin throughout the cell cycle.

1994 • 168 citations

Rapid changes in Drosophila transcription after an instantaneous heat shock.

1993 • 164 citations

The GAGA factor is required in the early Drosophila embryo not only for transcriptional regulation but also for nuclear division

1996 • 160 citations

Isolation of cDNAs encoding the Drosophila GAGA transcription factor.

1993 • 159 citations

Chromatin: Ga-ga over GAGA factor

1995 • 155 citations

HSF access to heat shock elements in vivo depends critically on promoter architecture defined by GAGA factor, TFIID, and RNA polymerase II binding sites.

1995 • 131 citations

The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high-affinity specific DNA binding.

1996 • 131 citations

Polar zippers: Their role in human disease

1994 • 126 citations

RNA polymerase II pauses at the 5' end of the transcriptionally induced Drosophila hsp70 gene.

1991 • 124 citations

Chromatin remodeling by GAGA factor and heat shock factor at the hypersensitive Drosophila hsp26 promoter in vitro.

1995 • 121 citations

Two homeo domain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos.

1994 • 112 citations

Sequence-specific transcriptional antirepression of the Drosophila Krüppel gene by the GAGA factor.

1991 • 107 citations

Distribution of GAGA protein on Drosophila genes in vivo.

1995 • 92 citations

Multiple isoforms of GAGA factor, a critical component of chromatin structure

1997 • 91 citations

Optimal heat-induced expression of the Drosophila hsp26 gene requires a promoter sequence containing (CT) · (GA) repeats

1990 • 87 citations

The BTB Domain of bric à brac Mediates Dimerization In Vitro

1995 • 75 citations

In Vivo Interactions of RNA Polymerase II with Genes of Drosophila melanogaster

1985 • 74 citations

Promoter sequence containing (CT)n · (GA)n repeats is critical for the formation of the DNase I hypersensitive sites in the Drosophila hsp26 gene

1992 • 74 citations

(CT)_n (GA)_n Repeats and Heat Shock Elements Have Distinct Roles in Chromatin Structure and Transcriptional Activation of the Drosophila hsp26 Gene

1993 • 62 citations

The Drosophila E74 promoter contains essential sequences downstream from the start site of transcription.

1989 • 61 citations

Multiple, compensatory regulatory elements specify spermatocyte-specific expression of the Drosophila melanogaster hsp26 gene.

1990 • 58 citations

Molecular Architecture of the hsp70 Promoter after Deletion of the TATA Box or the Upstream Regulation Region

1997 • 56 citations

Synthetic oligonucleotides recreate Drosophila fushi tarazu zebra-stripe expression.

1991 • 51 citations

The Dose of a Putative Ubiquitin-Specific Protease Affects Position-Effect Variegation in Drosophila melanogaster

1996 • 51 citations

Position-effect variegation in Drosophila depends on the dose of the gene encoding the E2F transcriptional activator and cell cycle regulator

1996 • 48 citations

RNA Polymerase II Pauses at the 5′ End of the Transcriptionally Induced Drosophila hsp70 Gene

1991 • 47 citations

Rapid Changes in Drosophila Transcription After an Instantaneous Heat Shock

1993 • 47 citations

Regulatory Elements Mediating Transcription from the Drosophila melanogaster Actin 5C Proximal Promoter

1990 • 47 citations

Transcription revisited: a commentary on the 1995 Cold Spring Harbor Laboratory meeting, "Mechanisms of Eukaryotic Transcription".

1996 • 46 citations

HSF recruitment and loss at mostDrosophila heat shock loci is coordinated and depends on proximal promoter sequences

1996 • 46 citations

Isolation of cDNAs Encoding the Drosophila GAGA Transcription Factor

1993 • 41 citations

Mutations of zeste that mediate transvection are recessive enhancers of position-effect variegation in Drosophila melanogaster.

1995 • 35 citations

Protein complexes for remodeling chromatin

1997 • 34 citations

Mutations in the Drosophila melanogaster Gene Encoding S-adenosylmethionine Suppress Position-Effect Variegation

1996 • 34 citations

Polymerase processivity and termination on Drosophila heat shock genes.

1993 • 32 citations

Induction and repression of the Drosophila Sgs-3 glue gene are mediated by distinct sequences in the proximal promoter.

1989 • 31 citations

The Drosophila Even-Skipped Promoter Is Transcribed in a Stage-Specific Manner In Vitro and Contains Multiple, Overlapping Factor-Binding Sites

1990 • 30 citations

Characterization and purification ofAdhdistal promoter factor 2, Adf-2, a cell-specific and promoter-specific repressor inDrosophila

1992 • 30 citations

Mapping of RNA polymerase on mammalian genes in cells and nuclei.

1992 • 23 citations

GAGA factor and TBF1 bind DNA elements that direct ubiquitous transcription of theDrosophilaα1-tubulin gene

1994 • 17 citations

Multiple, Compensatory Regulatory Elements Specify Spermatocyte- Specific Expression of the Drosophila melanogaster hsp26 Gene

1990 • 14 citations

Characterization of a sex-influenced modifier of gene expression and suppressor of position-effect variegation inDrosophila

1996 • 13 citations