Interleukin-2 and interleukin-12 mediate distinct effector mechanisms of liver allograft rejection

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Th1 And Th2 Cells: Different Patterns Of Lymphokine Secretion Lead To Different Functional Properties

1989 • 460 citations

Quantitative analysis of total macrophage content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80.

1985 • 413 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells.

1992 • 333 citations

CELLS MEDIATING ALLOGRAFT REJECTION

1991 • 330 citations

HEART ALLOGRAFTS IN MURINE SYSTEMS

1992 • 299 citations

Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway.

1991 • 298 citations

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection.

1994 • 290 citations

Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction.

1991 • 267 citations

Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen.

1994 • 247 citations

IN VIVO DEPLETION OF CD8+ T CELLS RESULTS IN Th2 CYTOKINE PRODUCTION AND ALTERNATE MECHANISMS OF ALLOGRAFT REJECTION

1995 • 190 citations

Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts.

1993 • 136 citations

SPLIT TOLERANCE INDUCED BY ORTHOTOPIC LIVER TRANSPLANTATION IN MICE1

1994 • 121 citations

ORTHOTOPIC LIVER TRANSPLANTATION IN THE MOUSE

1991 • 121 citations

PERIPHERAL TOLERANCE OF AN ALLOGRAFT IN ADULT RATS—CHARACTERIZATION BY LOW INTERLEUKIN-2 AND INTERFERON-γ mRNA LEVELS AND BY STRONG ACCUMULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX TRANSCRIPTS IN THE GRAFT

1992 • 117 citations

Interleukin 12 induces the differentiation of major histocompatibility complex class I-primed cytotoxic T-lymphocyte precursors into allospecific cytotoxic effectors.

1994 • 111 citations

CYTOKINE GENE EXPRESSION IN REJECTING CARDIAC ALLOGRAFTS

1992 • 106 citations

Orthotopic Liver Transplantation

2008 • 102 citations

Interleukin-12 Promotes the Proliferation and Cytolytic Maturation of Immune Effectors

1993 • 101 citations

Evidence for functional heterogeneity of rat CD4+ T cells in vivo. Differential expression of IL-2 and IL-4 mRNA in recipients of cardiac allografts.

1992 • 88 citations

LOCAL PRODUCTION OF CYTOKINES IN THE HUMAN CARDIAC ALLOGRAFT

1994 • 78 citations

CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines.

1993 • 76 citations

CD4-POSITIVE HELPER T LYMPHOCYTES MEDIATE MOUSE CARDIAC ALLOGRAFT REJECTION INDEPENDENT OF DONOR ALLOANTIGEN SPECIFIC CYTOTOXIC T LYMPHOCYTES

1993 • 75 citations

Tolerance to rat liver allografts. I. Differences between tolerance and rejection are more marked in the B cell compared with the T cell or cytokine response.

1994 • 72 citations

Cytokine Mrna Profiles In Mouse Orthotopic Liver Transplantation Graft Rejectionis Associasted With Augmented Th1 Function

1995 • 70 citations

Cytokine mRNA expression in endomyocardial biopsies during acute rejection from human heart transplants

1994 • 69 citations

The specificity of rejection and the absence of susceptibility of pancreatic islet beta cells to nonspecific immune destruction in mixed strain islets grafted beneath the renal capsule in the rat.

1989 • 52 citations

ALLOANTIGEN-DEPENDENT ENDOTHELIAL PHENOTYPE AND LYMPHOKINE mRNA EXPRESSION IN REJECTING MURINE CARDIAC ALLOGRAFTS

1993 • 49 citations

Spontaneous acceptance of rat liver allografts is associated with an early downregulation of intragraft interleukin-4 messenger RNA expression

1995 • 46 citations

IMMUNE MECHANISMS IN ORGAN ALLOGRAFT REJECTION

1983 • 45 citations

Interactions between T lymphocyte subsets supported by interleukin 2-rich lymphokines produce acute rejection of vascularized cardiac allografts in T cell deprived rats.

1984 • 44 citations

PREVENTION OF ORTHOTOPIC LIVER ALLOGRAFT REJECTION IN RATS WITH A SHORT-TERM BREQUINAR SODIUM THERAPY

1994 • 41 citations

IL-2 AND IL-5 GENE EXPRESSION IN RESPONSE TO ALLOANTIGEN IN LIVER ALLOGRAFT RECIPIENTS AND IN VITRO

1993 • 37 citations

Natural killer cell stimulatory factor (NKSF) augments natural killer cell and antibody-dependent tumoricidal response against colon carcinoma cell lines

1991 • 37 citations

Adoptive transfer of a T_h2-like cell line prolongs MHC class II antigen disparate skin allograft survival in the mouse

1994 • 36 citations

ACUTE LIVER ALLOGRAFT REJECTION IN THE RAT

1995 • 36 citations

EVIDENCE THAT RAPAMYCIN INHIBITS INTERLEUKIN-12-INDUCED PROLIFERATION OF ACTIVATED T LYMPHOCYTES

1994 • 34 citations

Lack of an obligate role for IFN-gamma in the primary in vitro mixed lymphocyte response.

1988 • 29 citations

Effect of recombinant interferon gamma and interleukin-2 and of a monoclonal antibody against interferon gamma on the rat immune response against heart allografts.

1991 • 23 citations

Presensitization by skin grafting from major histocompatibility complex class I or major histocompatibility complex class II deficient mice identifies class I antigens as inducers of allosensitization.

1995 • 21 citations

Graft cytokine mRNA activity in rat single lung transplants by reverse transcription-polymerase chain reaction: effect of cyclosporine.

1992 • 18 citations

EVIDENCE THAT RAPAMYCIN INHIBITS INTERLEUKIN-12-INDUCED PROLIFERATION OF ACTIVATED T LYMPHOCYTES

1994 • 5 citations

SPLIT TOLERANCE INDUCED BY ORTHOTOPIC LIVER TRANSPLANTATION IN MICE1

1994 • 4 citations

Adoptive transfer of a Th2-like cell line prolongs MHC class II antigen disparate skin allograft survival in the mouse

1994 • 2 citations

Deleted Work

1955 • 0 citations