Quantitative comparisons of in vitro assays for estrogenic activities.

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β

1998 • 4,127 citations

The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants.

1995 • 1,714 citations

Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop.

1996 • 1,076 citations

Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor

1998 • 987 citations

Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse

1997 • 968 citations

The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands

2000 • 784 citations

The estrogenic activity of phthalate esters in vitro.

1997 • 780 citations

Evaluation of Chemicals with Endocrine Modulating Activity in a Yeast-Based Steroid Hormone Receptor Gene Transcription Assay

1997 • 662 citations

Use of Structure−Activity Data To Compare Structure-Based Clustering Methods and Descriptors for Use in Compound Selection

1996 • 625 citations

The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site

1997 • 611 citations

Phytoestrogen Interaction with Estrogen Receptors in Human Breast Cancer Cells*

1978 • 605 citations

Membrane estrogen receptors identified by multiple antibody labeling and impeded‐ligand binding

1995 • 532 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals

1999 • 440 citations

Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays.

1996 • 434 citations

The E-SCREEN Assay as a Tool to Identify Estrogens: An Update on Estrogenic Environmental Pollutants

1995 • 379 citations

Evaluation of a recombinant yeast cell estrogen screening assay.

1997 • 340 citations

In Vitro Bioassays for Assessing Estrogenic Substances

1997 • 324 citations

Research Needs for the Risk Assessment of Health and Environmental Effects of Endocrine Disruptors: A Report of the U.S. EPA-Sponsored Workshop

1996 • 313 citations

Identification of Estrogen Receptor β2, A Functional Variant of Estrogen Receptor β Expressed in Normal Rat Tissues

1998 • 313 citations

Rapid screening of environmental chemicals for estrogen receptor binding capacity.

1998 • 309 citations

The Rodent Uterotrophic Assay: Critical Protocol Features, Studies with Nonyl Phenols, and Comparison with a Yeast Estrogenicity Assay

1997 • 276 citations

The role of estrogens on the proliferation of human breast tumor cells (MCF-7)

1985 • 257 citations

Hydroxylated Polychlorinated Biphenyls (PCBs) as Estrogens and Antiestrogens: Structure–Activity Relationships

1997 • 241 citations

Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation

1978 • 240 citations

Association Rules and Data Mining in Hospital Infection Control and Public Health Surveillance

1998 • 225 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens

1995 • 206 citations

Ligand-Based Identification of Environmental Estrogens

1996 • 205 citations

Survey and Assessment of Mammalian Estrogen Biological Assays for Hazard Characterization

1996 • 159 citations

Exoestrogens: Mechanisms of action and strategies for identification and assessment

1998 • 153 citations

Identification and assessment of endocrine disruptors: limitations of in vivo and in vitro assays.

1998 • 148 citations

Transcriptional activation of the human estrogen receptor by DDT isomers and metabolites in yeast and MCF-7 cells

1997 • 126 citations

QSAR Models for Binding of Estrogenic Compounds to Estrogen Receptor α and β Subtypes

1997 • 126 citations

3,4,3',4'-Tetrachlorobiphenyl acts as an estrogen in vitro and in vivo.

1996 • 125 citations

Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture.

1997 • 122 citations

Antiestrogens: Mechanisms and actions in target cells

1995 • 110 citations

Diethylstilbestrol and Estradiol Binding to Serum Albumin and Pregnancy Plasma of Rat and Human*

1979 • 108 citations

Identification of a Third Autonomous Activation Domain within the Human Estrogen Receptor

1997 • 101 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells.

1990 • 90 citations

The structural pervasiveness of estrogenic activity.

1995 • 88 citations

The other estrogen receptor in the plasma membrane: implications for the actions of environmental estrogens.

1995 • 88 citations

3,4,3',4'-Tetrachlorobiphenyl acts as an estrogen in vitro and in vivo

1996 • 85 citations

Quantitative structure-activity relationships (QSARs) for estrogen binding to the estrogen receptor: predictions across species.

1997 • 80 citations

Differential Sensitivity of Rat Uterine Growth and Epithelium Hypertrophy to Estrogens and Antiestrogens

1993 • 73 citations

Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse hepa 1c1c7 cells

1991 • 73 citations

Induction of the Estrogen Specific Mitogenic Response of MCF-7 Cells by Selected Analogues of Estradiol-17β: A 3D QSAR Study

1997 • 68 citations

Chlorinated hydrocarbons: estrogens and antiestrogens

1995 • 65 citations

The Estrogenic Activity of Phthalate Esters in Vitro

1997 • 62 citations

Control of cell proliferation: evidence for negative control on estrogen-sensitive T47D human breast cancer cells.

1986 • 58 citations

Human serum albumin shares the properties of estrocolyone-I, the inhibitor of the proliferation of estrogen-target cells

1996 • 57 citations

A Testing Deadline for Endocrine Disrupters

1996 • 56 citations

Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals

1999 • 49 citations

Evaluation of a Recombinant Yeast Cell Estrogen Screening Assay

1997 • 47 citations

Assessing Environmental Chemicals for Estrogenicity Using a Combination of In Vitro and In Vivo Assays

1996 • 46 citations

Environmental Toxicology and Risk Assessment: Standardization of Biomarkers for Endocrine Disruption and Environmental Assessment: 8th Volume

1999 • 45 citations

Flavonoids Inhibit Estrogen Binding to Rat Alpha-Fetoprotein

1998 • 45 citations

Data mining for regulatory elements in yeast genome.

1997 • 41 citations

The Estrogen Receptor as a Target for Rational Drug Design

1995 • 38 citations

Estrogenic Activity of Natural and Synthetic Estrogens in Human Breast Cancer Cells in Culture

1997 • 34 citations

Identification and Assessment of Endocrine Disruptors: Limitations of in Vivo and in Vitro Assays

1998 • 34 citations

Identification of a Third Autonomous Activation Domain within the Human Estrogen Receptor

1997 • 29 citations

Pathology information systems: data mining leads to knowledge discovery.

1998 • 26 citations

Rapid Screening of Environmental Chemicals for Estrogen Receptor Binding Capacity

1998 • 24 citations

Survey and Assessment of Mammalian Estrogen Biological Assays for Hazard Characterization

1996 • 24 citations

EXOESTROGENS: MECHANISMS OF ACTION AND STRATEGIES FOR IDENTIFICATION AND ASSESSMENT

1998 • 18 citations

The Other Estrogen Receptor in the Plasma Membrane: Implications for the Actions of Environmental Estrogens

1995 • 16 citations

Gas Chromatographic and Mass Spectrometric Characterization of Impurities in Technical Methoxychlor

1980 • 11 citations

In Vitro Endocrine Disruptor Screening

1999 • 8 citations