Hydroxylated Polychlorinated Biphenyls (PCBs) as Estrogens and Antiestrogens: Structure–Activity Relationships

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment

1994 • 1,717 citations

The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants.

1995 • 1,714 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

Polychlorinated Biphenyls (PCBs) and Polybrominated Biphenyls (PBBs): Biochemistry, Toxicology, and Mechanism of Action

1984 • 793 citations

An estrogen-responsive element derived from the 5′ flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells

1986 • 729 citations

Environmental occurrence, abundance, and potential toxicity of polychlorinated biphenyl congeners: considerations for a congener-specific analysis.

1989 • 682 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

1994 • 649 citations

Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines.

1989 • 614 citations

Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products

1989 • 573 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

1996 • 505 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: conformationally restricted structural probes.

1988 • 429 citations

Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin

1993 • 374 citations

Mechanistic aspects of dioxin action

1993 • 372 citations

Structural Organization and Expression of the Mouse Estrogen Receptor

1987 • 365 citations

Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships.

1983 • 307 citations

Selective retention of hydroxylated PCB metabolites in blood.

1994 • 299 citations

Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin

1986 • 260 citations

Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptor

1982 • 258 citations

A new cellular model of response to estrogens: a bioluminescent test to characterize (anti) estrogen molecules.

1990 • 233 citations

Lightly chlorinated ortho-substituted PCB congeners decrease dopamine in nonhuman primate brain and in tissue culture

1990 • 205 citations

Critical evaluation of polychlorinated biphenyl toxicity in terrestrial and marine mammals: Increasing impact of non-ortho and mono-ortho coplanar polychlorinated biphenyls from land to ocean

1989 • 193 citations

Uterine peroxidase as a marker for estrogen action.

1977 • 161 citations

Antiestrogenic Activity of Hydroxylated Polychlorinated Biphenyl Congeners Identified in Human Serum

1997 • 159 citations

Comparative Effects of Two Polychlorinated Biphenyl Congeners on Calcium Homeostasis in Rat Cerebellar Granule Cells

1993 • 156 citations

Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology

1987 • 150 citations

Human estrogen receptor forms multiple protein-DNA complexes.

1990 • 126 citations

Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced pS2 expression.

1994 • 124 citations

Competitive inhibition of thyroxin binding to transihyretin by monohy-droxy metabolites of 3,4,3′,4′-tetrachlorobiphenyl

1990 • 116 citations

Comparison of effects of Aroclors 1016 and 1260 on non-human primate catecholamine function

1991 • 115 citations

Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.

1991 • 99 citations

The structural pervasiveness of estrogenic activity.

1995 • 88 citations

Increased (3H) Phorbol Ester Binding in Rat Cerebellar Granule Cells by Polychlorinated Biphenyl Mixtures and Congeners: Structure-Activity Relationships

1995 • 87 citations

Assessing the estrogenic and dio×in-like activities of chemicals and comple× mi×tures using in vitro recombinant receptor–reporter gene assays

1996 • 81 citations

Study on the mechanism of interference of 3,4,3′,4′-tetrachlorobiphenyl with the plasma retinol-binding proteins in rodents

1988 • 78 citations

Uterine Estrogen Receptor Interaction with Estrogen-Responsive DNA Sequencesin Vitro: Effects of Ligand Binding on Receptor-DNA Complexes

1990 • 73 citations

Biotransformation of PCBs: Metabolic Pathways and Mechanisms

1987 • 63 citations

Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats

1995 • 61 citations

Heterologous expression of human uteroglobin/polychlorinated biphenyl-binding protein. Determination of ligand binding parameters and mechanism of phospholipase A2 inhibition in vitro.

1994 • 57 citations

Target cells for the polychlorinated biphenyl metabolite 4,4'-bis(methylsulfonyl)-2,2',5,5'-tetrachlorobiphenyl in lung and kidney.

1985 • 50 citations

Relative tumour promoting activity of three polychlorinated biphenyls in rat liver

1993 • 44 citations

Stable luciferase transfected cells for studying steroid receptor biological activity

1994 • 43 citations

Polyhalogenated aromatics: uptake, disposition and metabolism

1989 • 43 citations

Sensitivity of adenosine triphosphatases in different brain regions to polychlorinated biphenyl congeners

1994 • 35 citations

Estrogen action in target cells: selective requirements for activation of different hormone response elements

1995 • 27 citations

Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by 3,3′,4,4′-tetrachlorobiphenyl and 2,2′,4,4′,5,5′- hexachiorobiphenyl in rats initiated with diethylnitrosamine

1995 • 22 citations

Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum

1995 • 17 citations

Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and related compounds : environmental and mechanistic considerations with support the development of toxic equivalency factors (TEFs)

1990 • 16 citations