The Selectivity of Small Molecules Towards Protein Tyrosine Kinases

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

1997 • 1,098 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

2000 • 897 citations

Mechanism-Based Target Identification and Drug Discovery in Cancer Research

2000 • 607 citations

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

1988 • 593 citations

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

1998 • 477 citations

Crystal Structure of Hck in Complex with a Src Family–Selective Tyrosine Kinase Inhibitor

1999 • 428 citations

Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-X _L and caspase-3-like proteases

1998 • 348 citations

Prevention of Lipopolysaccharide-Induced Lethal Toxicity by Tyrosine Kinase Inhibitors

1994 • 339 citations

Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases

1994 • 287 citations

The TEL/platelet-derived growth factor β receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFβR kinase-dependent signaling pathways

1996 • 285 citations

Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.

1994 • 272 citations

Epidermal growth factor receptor tyrosine kinase

1994 • 258 citations

Tyrphostins. 5. Potent Inhibitors of Platelet-Derived Growth Factor Receptor Tyrosine Kinase: Structure−Activity Relationships in Quinoxalines, Quinolines, and Indole Tyrphostins

1996 • 225 citations

Signal-Transduction Therapy. A Novel Approach to Disease Management

1994 • 188 citations

Substrate Competitive Inhibitors of IGF-1 Receptor Kinase

2000 • 153 citations

Phosphorylation Site-Specific Inhibition of Platelet-Derived Growth Factor β-Receptor Autophosphorylation by the Receptor Blocking Tyrphostin AG1296

1997 • 132 citations

Targeting signal transduction for disease therapy

1996 • 127 citations

A Dual Inhibitor of Platelet-Derived Growth Factor β-Receptor and Src Kinase Activity Potently Interferes With Motogenic and Mitogenic Responses to PDGF in Vascular Smooth Muscle Cells

1999 • 112 citations

The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice.

1991 • 111 citations

Selective interactions of transforming and normal abl proteins with ATP, tyrosine-copolymer substrates, and tyrphostins.

1992 • 99 citations

Enhancement of chemosensitivity by tyrphostin AG825 in high-p185(neu) expressing non-small cell lung cancer cells.

1996 • 89 citations

Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal growth factor receptor and analysis by a new computer program.

1994 • 70 citations

Kinetic model of the epidermal growth factor (EGF) receptor tyrosine kinase and a possible mechanism of its activation by EGF.

1992 • 62 citations

Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes.

1997 • 53 citations

Tyrosine kinase inhibition ameliorates the hyperdynamic state and decreases nitric oxide production in cirrhotic rats with portal hypertension and ascites.

1997 • 50 citations

Tyrphostin AG 556 improves survival and reduces multiorgan failure in canine Escherichia coli peritonitis.

1997 • 49 citations

Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors

1999 • 47 citations

Late Administration of a Lipophilic Tyrosine Kinase Inhibitor Prevents Lipopolysaccharide and Escherichia coli-Induced Lethal Toxicity

1996 • 42 citations

Tyrphostins suppress the growth of psoriatic keratinocytes

1995 • 35 citations

SRC as a target for anti-cancer drugs.

1996 • 34 citations

pp60cSrc Is a Caspase-3 Substrate and Is Essential for the Transformed Phenotype of A431 Cells

2000 • 32 citations

Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes.

1999 • 27 citations

Altered efficacy and selectivity of tyrosine kinase inhibitors of the activated states of protein tyrosine kinases.

1998 • 9 citations