bcl-2 overexpression combined with p53 protein accumulation correlates with hormone-refractory prostate cancer

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Tumor suppressor genes

1991 • 775 citations

bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 • 684 citations

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

1993 • 597 citations

Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo.

1995 • 537 citations

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

1994 • 513 citations

Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance.

1982 • 500 citations

p53 Protein Accumulation and Gene Mutation in the Progression of Human Prostate Carcinoma

1993 • 488 citations

Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation.

1990 • 485 citations

Down-regulation of bcl-2 by p53 in breast cancer cells.

1994 • 479 citations

bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer

1994 • 326 citations

Small Subgroup of Aggressive, Highly Proliferative Prostatic Carcinomas Defined by p53 Accumulation

1992 • 317 citations

Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle.

1992 • 245 citations

Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation.

1993 • 201 citations

p53 and bcl-2 expression in high-grade B-cell lymphomas: correlation with survival time

1994 • 188 citations

p53, c-erbB-2 and the Epidermal Growth Factor Receptor in the Benign and Malignant Prostate

1992 • 169 citations

Problems with p53 immunohistochemical staining: the effect of fixation and variation in the methods of evaluation

1994 • 152 citations

Immunohistochemically detectable bcl-2 expression in colorectal carcinoma: correlation with tumour stage and patient survival

1995 • 131 citations

Immunohistochemical Determination of P53 Protein Nuclear Accumulation in Prostatic Adenocarcinoma

1994 • 116 citations

Frequency of apoptotic bodies positively correlates with Gleason grade in prostate cancer

1994 • 97 citations

Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lymphomagenesis.

1994 • 67 citations

Castration induces apoptosis in the ventral prostate but not in an androgen-sensitive prostatic adenocarcinoma in the rat.

1994 • 54 citations

Accumulation of the p53 protein occurs more frequently in metastatic than in localized prostatic adenocarcinomas

1994 • 49 citations