A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress

Signal integration in the endoplasmic reticulum unfolded protein response

2007 • 5,948 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Mediators of endoplasmic reticulum stress‐induced apoptosis

2006 • 2,212 citations

Molecular Chaperones and Protein Quality Control

2006 • 1,512 citations

IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

2007 • 1,292 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response

2006 • 1,231 citations

Orchestrating the unfolded protein response in health and disease

2002 • 1,163 citations

A chemical switch for inhibitor-sensitive alleles of any protein kinase

2000 • 1,032 citations

XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

2004 • 978 citations

Orchestrating the unfolded protein response in health and disease

2002 • 966 citations

Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

2002 • 909 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

The unfolded protein response

2006 • 575 citations

On the mechanism of sensing unfolded protein in the endoplasmic reticulum

2005 • 561 citations

Intracellular Signaling by the Unfolded Protein Response

2006 • 526 citations

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

1997 • 415 citations

The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

2006 • 354 citations

Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

2001 • 299 citations

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

2000 • 260 citations

Role of Disulfide Bridges Formed in the Luminal Domain of ATF6 in Sensing Endoplasmic Reticulum Stress

2006 • 254 citations

Bypassing a Kinase Activity with an ATP-Competitive Drug

2003 • 234 citations

Building an antibody factory: a job for the unfolded protein response

2004 • 109 citations