Intracellular K+ Suppresses the Activation of Apoptosis in Lymphocytes

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Proteins: Structures and Molecular Properties

1986 • 2,694 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Proteins. Structures and molecular properties

1984 • 1,247 citations

Molecular biology of the cell

1983 • 1,007 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Fluorescent indicators for cytosolic sodium

1989 • 650 citations

Regulation of cellular volume.

1977 • 607 citations

The role of proteases during apoptosis

1996 • 558 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis

1993 • 428 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

Programmed cell death in Caenorhabditis elegans

1994 • 379 citations

Osmoregulatory Salt Transporting Mechanisms: Control of Cell Volume in Anisotonic Media

1981 • 360 citations

ICE-like proteases in apoptosis

1995 • 353 citations

Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase.

1994 • 345 citations

Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B.

1991 • 301 citations

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 • 298 citations

Potassium-inhibited processing of IL-1 beta in human monocytes.

1995 • 282 citations

Novel path to apoptosis: small transmembrane pores created by staphylococcal alpha-toxin in T lymphocytes evoke internucleosomal DNA degradation

1994 • 234 citations

Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes

1996 • 227 citations

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

1992 • 225 citations

Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells.

1990 • 216 citations

Volume-induced increase of anion permeability in human lymphocytes.

1982 • 202 citations

The Genetics of Programmed Cell Death in the Nematode Caenorhabditis elegans

1994 • 195 citations

Identification of a glucocorticoid-induced nuclease in thymocytes. A potential “lysis gene” product.

1987 • 167 citations

Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.

1996 • 165 citations

Native Recombinant Cyclophilins A, B, and C Degrade DNA Independently of Peptidylprolyl cis-trans-Isomerase Activity

1997 • 161 citations

The ICE family of cysteine proteases as effectors of cell death.

1996 • 158 citations

Human eosinophils in culture undergo a striking and rapid shrinkage during apoptosis. Role of K+ channels

1995 • 146 citations

DNA in chromatin of irradiated lymphoid tissues degrades in vivo into regular fragments

1976 • 145 citations

Intracellular Ionic Variations in the Apoptotic Death of L Cells by Inhibitors of Cell Cycle Progression

1995 • 138 citations

ICE/CED-3 proteasesin apoptosis

1996 • 128 citations

Characterization of cell volume loss in CEM-C7A cells during dexamethasone-induced apoptosis

1996 • 114 citations

Conformations and forces in protein folding

1992 • 111 citations

Human Monocyte Interleukin-1β Posttranslational Processing

1996 • 102 citations

Reevaluation of the Role of de Novo Protein Synthesis in Rat Thymocyte Apoptosis

1995 • 82 citations

Cation and anion transport pathways in volume regulatory response of human lymphocytes to hyposmotic media

1985 • 67 citations

The effect of salt on the Michaelis Menten constant of the HIV‐1 protease correlates with the Hofmeister series

1991 • 66 citations

Internucleosomal Deoxyribonucleic Acid Cleavage Activity in Apoptotic Thymocytes: Detection and Endocrine Regulation*

1991 • 61 citations

Glucocorticoids Stimulate Ribonucleic Acid Degradation in Isolated Rat Thymic Lymphocytes in Vitro*

1982 • 58 citations

Mechanism of tissue-specific induction of internucleosomal deoxyribonucleic acid cleavage activity and apoptosis by glucocorticoids.

1993 • 54 citations

Cell volume and ion transport regulation

1994 • 46 citations

Degradation of the Light-Stress Protein is Mediated by an ATP-Independent, Serine-Type Protease Under Low-Light Conditions

1996 • 41 citations

Utilization of an in vitro assay to evaluate chromatin degradation by candidate apoptotic nucleases

1997 • 31 citations

Effects of ionic strength on the catalysis and stability of prolyl oligopeptidase

1995 • 30 citations

Purification and properties of nuclease SP

1991 • 27 citations

Cleavage of the Lys196-Ser197 bond of prolyl oligopeptidase: Enhanced catalytic activity for one of the two resulting active enzyme forms

1992 • 23 citations

The involvement of RNA and protein synthesis in programmed cell death (apoptosis) in human leukaemia HL-60 cells

1990 • 17 citations

Kinetic Characterization of Soybean Seedling Amine Oxidase

1995 • 13 citations

Endo-deoxyribonuclease from Streptomyces rimosus

1995 • 4 citations