The T-cell-receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

CLUSTAL: a package for performing multiple sequence alignment on a microcomputer

1988 • 3,446 citations

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

Genetic applications of an inverse polymerase chain reaction.

1988 • 1,867 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.

1989 • 1,000 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

Polymerase Chain Reaction with Single-Sided Specificity: Analysis of T Cell Receptor δ Chain

1989 • 640 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Autoimmune Diseases: The Failure of Self Tolerance

1990 • 495 citations

Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families

1988 • 448 citations

Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

1989 • 416 citations

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

1990 • 395 citations

Predominantly T-Cell Infiltrate in Rheumatoid Synovial Membranes

1975 • 387 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.

1989 • 376 citations

Diversity and structure of human T-cell receptor alpha-chain variable region genes.

1987 • 274 citations

Clonal dominance among T-lymphocyte infiltrates in arthritis.

1988 • 268 citations

One-sided polymerase chain reaction: the amplification of cDNA.

1989 • 241 citations

Sequences and repertoire of the human T cell receptor α and β chain variable region genes in thymocytes

1987 • 226 citations

Identification of Putative Human T Cell Receptor δ Complementary DNA Clones

1987 • 187 citations

Predominant Expression of T Cell Receptor V _α 7 in Tumor-Infiltrating Lymphocytes of Uveal Melanoma

1990 • 169 citations

Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies.

1990 • 164 citations

Bias toward use of a specific T cell receptor beta-chain variable region in a subgroup of individuals with sarcoidosis.

1988 • 156 citations

Studies on the human T cell receptor α/β variable region genes. II. Identification of four additional V_β subfamilies

1991 • 148 citations

Studies on the human T cell receptor α/β variable region genes. I. Identification of 7 additional V_α subfamilies and 14 J_α gene segments

1991 • 121 citations

Homogenous junctional sequence of the V14+ T-cell antigen receptor alpha chain expanded in unprimed mice.

1990 • 114 citations

T cell antigen receptor V gene usage. Increases in V beta 8+ T cells in Crohn's disease.

1990 • 113 citations

Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis.

1989 • 108 citations

T cell receptor gene rearrangements of T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis (PBC): Oligoclonality of PBC‐derived T cell clones

1990 • 95 citations

T cell receptor V beta gene usage in a human alloreactive response. Shared structural features among HLA-B27-specific T cell clones.

1990 • 94 citations

T cell receptor beta-chain selection in human allograft rejection.

1989 • 81 citations

A method for multiple sequence alignment with gaps

1989 • 80 citations

Structure of t cell antigen receptor β chain in synovial fluid cells from patients with rheumatoid arthritis

1988 • 78 citations

A Minority of Patients with Rheumatoid Arthritis Show a Dominant Rearrangement of T‐Cell Receptor β Chain Genes in Synovial Lymphocytes

1987 • 77 citations

Human T-cell tumours containing chromosome 14 inversion or translocation with breakpoints proximal to immunoglobulin joining regions at 14q32.

1987 • 75 citations

Surprisingly uneven distribution of the T cell receptor V beta repertoire in wild mice.

1990 • 69 citations

Dominant T‐Cell Receptor β‐Chain Gene Rearrangements Indicate Clonal Expansion in the Rheumatoid Joint

1990 • 57 citations

Heterogeneity of T cell receptor idiotypes in rheumatoid arthritis.

1988 • 53 citations

T cell antigen receptors in autoimmunity.

1988 • 46 citations

Use of a variable alpha region to create a functional T-cell receptor delta chain.

1988 • 44 citations

Thyroglobulin antibodies in Graves' disease are associated with T-cell receptor beta chain and major histocompatibility complex loci.

1989 • 25 citations

T cell receptor phenotypes in autoimmune thyroid disease

1990 • 23 citations

Organization of the T-cell receptor alpha-chain gene and rearrangement in human T-cell leukaemias.

1986 • 16 citations

Imprint of Thymic Selection on Autoreactive Repertoires

1990 • 12 citations

Experimental basis of innovative therapies of rheumatoid arthritis.

1989 • 6 citations