Lovastatin Decreases De Novo Cholesterol Synthesis and LDL Apo B-100 Production Rates in Combined-Hyperlipidemic Males

Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

1993 • 28,274 citations

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 8,631 citations

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

1995 • 7,378 citations

Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia

1987 • 3,889 citations

The Lipid Research Clinics Coronary Primary Prevention Trial Results

1984 • 2,673 citations

Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol.

1982 • 2,206 citations

Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease

1994 • 1,697 citations

The Lipid Research Clinics Coronary Primary Prevention Trial Results

1984 • 1,373 citations

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 • 562 citations

Automated enzymatic standardized lipid analyses for plasma and lipoprotein fractions

1987 • 529 citations

Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells.

1993 • 371 citations

Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans.

1988 • 303 citations

Influence of Pravastatin, a Specific Inhibitor of HMG-CoA Reductase, on Hepatic Metabolism of Cholesterol

1990 • 276 citations

Regulation of apoB secretion from HepG2 cells: evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge.

1990 • 273 citations

Lovastatin (Mevinolin) in the Treatment of Heterozygous Familial Hypercholesterolemia

1987 • 215 citations

Influence of mevinolin on metabolism of low density lipoproteins in primary moderate hypercholesterolemia.

1985 • 210 citations

Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: implications for the pathophysiology of apoB production.

1990 • 210 citations

Substrate delivery as a determinant of hepatic apoB secretion.

1993 • 202 citations

Plasma apolipoprotein changes in the triglyceride-rich lipoprotein fraction of human subjects fed a fat-rich meal

1988 • 198 citations

Suppression of apolipoprotein B production during treatment of cholesteryl ester storage disease with lovastatin. Implications for regulation of apolipoprotein B synthesis.

1987 • 196 citations

Evidence for diurnal periodicity in human cholesterol synthesis.

1990 • 181 citations

Hypocholesterolemic effects of mevinolin in patients with heterozygous familial hypercholesterolemia.

1984 • 176 citations

Therapeutic response to lovasatain (Mevinolin) in nonfamilial hypercholesterolemia - A Multicenter study

1986 • 175 citations

Therapeutic Response to Lovastatin (Mevinolin) in Nonfamilial Hypercholesterolemia

1986 • 160 citations

Lovastatin therapy in nephrotic hyperlipidemia: Effects on lipoprotein metabolism

1988 • 129 citations

Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance.

1984 • 124 citations

Enzyme-linked immunosorbent assay for human plasma apolipoprotein B

1987 • 119 citations

Pravastatin therapy in primary moderate hypercholesterolaemia: changes in metabolism of apolipoprotein B‐containing lipoproteins

1990 • 118 citations

Comparison of deuterated leucine, valine, and lysine in the measurement of human apolipoprotein A-I and B-100 kinetics

1990 • 117 citations

Effects of simvastatin on apoB metabolism and LDL subfraction distribution.

1993 • 108 citations

Regulation of apolipoprotein B production and secretion in response to the change of intracellular cholesteryl ester contents in rabbit hepatocytes

1993 • 104 citations

Impact of age on the metabolism of VLDL, IDL, and LDL apolipoprotein B-100 in men.

1995 • 99 citations

Prediction of the parameters of whole body cholesterol metabolism in humans.

1980 • 96 citations

Lovastatin therapy in familial dysbetalipoproteinemia: Effects on kinetics of apolipoprotein B

1988 • 83 citations

Human cholesterol synthesis measurement using deuterated water. Theoretical and procedural considerations.

1993 • 74 citations

Measurement of human apolipoprotein B-48 and B-100 kinetics in triglyceride-rich lipoproteins using [5,5,5-2H3]leucine.

1992 • 67 citations

The hypolipidemic effects of lovastatin and clofibrate alone and in combination in patients with type III hyperlipoproteinemia

1990 • 54 citations

Plasma cholesterol synthesis using deuterated water in humans: effect of short-term food restriction.

1988 • 51 citations

Simvastatin decreases the hepatic secretion of very‐low‐density lipoprotein apolipoprotein B‐100 in heterozygous familial hypercholesterolaemia: pathophysiological and therapeutic implications

1995 • 47 citations

Reduction in plasma low-density lipoprotein cholesterol and urinary mevalonic acid by lovastatin in patients with heterozygous familial hypercholesterolemia

1989 • 45 citations

Effect of simvastatin on receptor-dependent low density lipoprotein catabolism in normocholesterolemic human volunteers

1989 • 45 citations

Contrasting effects of lovastatin and cholestyramine on low-density lipoprotein cholesterol and 24-hour urinary mevalonate excretion in patients with heterozygous familial hypercholesterolemia.

1989 • 39 citations

Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells

1990 • 37 citations

Interaction of dietary fat saturation and cholesterol level on cholesterol synthesis measured using deuterium incorporation.

1994 • 37 citations

Effect of pravastatin on metabolic parameters of apolipoprotein B in patients with mixed hyperlipoproteinemia

1993 • 32 citations

Physiologic mechanisms of action of lovastatin in nephrotic syndrome

1995 • 30 citations