AMP-activated Protein Kinase (AMPK) Signaling in Endothelial Cells Is Essential for Angiogenesis in Response to Hypoxic Stress

Mechanisms of angiogenesis and arteriogenesis

2000 • 4,120 citations

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1999 • 3,529 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1999 • 2,577 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

2000 • 1,427 citations

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

1996 • 1,222 citations

Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.

1998 • 1,191 citations

Clinical applications of angiogenic growth factors and their inhibitors

1999 • 1,017 citations

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

2001 • 1,012 citations

Role of Akt Signaling in Vascular Homeostasis and Angiogenesis

2002 • 981 citations

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

2001 • 960 citations

A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

2001 • 935 citations

HIF-1 and human disease: one highly involved factor

2000 • 900 citations

AMP‐activated protein kinase phosphorylation of endothelial NO synthase

1999 • 827 citations

Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport

1998 • 749 citations

Phosphorylation of Thr ⁴⁹⁵ Regulates Ca ²⁺ /Calmodulin-Dependent Endothelial Nitric Oxide Synthase Activity

2001 • 740 citations

High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5’-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase

1995 • 582 citations

Akt Mediates Cytoprotection of Endothelial Cells by Vascular Endothelial Growth Factor in an Anchorage-dependent Manner

1999 • 557 citations

Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase

2001 • 547 citations

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

2000 • 529 citations

Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

2000 • 524 citations

Purification and characterization of the AMP‐activated protein kinase

1989 • 413 citations

Vascular Endothelial Growth Factor–Stimulated Actin Reorganization and Migration of Endothelial Cells Is Regulated via the Serine/Threonine Kinase Akt

2000 • 413 citations

AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target

1999 • 394 citations

Coordinate Regulation of Malonyl-CoA Decarboxylase,sn-Glycerol-3-phosphate Acyltransferase, and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase in Rat Tissues in Response to Exercise

2002 • 369 citations

Phosphorylation of the endothelial nitric oxide synthase at Ser‐1177 is required for VEGF‐induced endothelial cell migration

2000 • 363 citations

Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.

1994 • 330 citations

Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells

2002 • 325 citations

The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

1989 • 303 citations

Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.

1990 • 301 citations

Increased Adenosine Monophosphate–Activated Protein Kinase Activity in Rat Hearts With Pressure-Overload Hypertrophy

2001 • 300 citations

Location and function of three sites phosphorylated on rat acetyl‐CoA carboxylase by the AMP‐activated protein kinase

1990 • 262 citations

Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism

1994 • 251 citations

Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia

1996 • 248 citations

Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP‐activated protein kinase

1991 • 217 citations

Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival

1999 • 214 citations

Vascular Endothelial Growth Factor Up-regulates ICAM-1 Expression via the Phosphatidylinositol 3 OH-kinase/AKT/Nitric Oxide Pathway and Modulates Migration of Brain Microvascular Endothelial Cells

2000 • 214 citations

Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo

2000 • 209 citations

Acute Regulation of Fatty Acid Oxidation and AMP-Activated Protein Kinase in Human Umbilical Vein Endothelial Cells

2001 • 200 citations

Modulation by Peroxynitrite of Akt- and AMP-activated Kinase-dependent Ser1179 Phosphorylation of Endothelial Nitric Oxide Synthase

2002 • 190 citations

Podokinesis in endothelial cell migration: role of nitric oxide

1998 • 189 citations

Vascular Endothelial Growth Factor–Induced Endothelial Cell Migration and Proliferation Depend on a Nitric Oxide–Mediated Decrease in Protein Kinase Cδ Activity

1999 • 174 citations

VEGF ₁₆₅ Expressed by a Replication-Deficient Recombinant Adenovirus Vector Induces Angiogenesis In Vivo

1995 • 159 citations

Myogenic Akt Signaling Regulates Blood Vessel Recruitment during Myofiber Growth

2002 • 157 citations

Angiogenesis in Embryos and Ischemic Diseases

1997 • 139 citations

Expression of the AMP‐activated protein kinase β1 and β2 subunits in skeletal muscle

1999 • 131 citations

Signaling Angiogenesis via p42/p44 MAP Kinase Cascade

2000 • 131 citations

Involvement of Endothelial Nitric Oxide in Sphingosine-1-Phosphate–Induced Angiogenesis

2002 • 121 citations

Regulation of Angiogenesis by Glycogen Synthase Kinase-3β

2002 • 120 citations

Control of Hepatic Fatty Acid Oxidation by 5′-AMP-Activated Protein Kinase Involves a Malonyl-CoA-Dependent and a Malonyl-CoA-Independent Mechanism

1997 • 115 citations

Decorin-mediated Signal Transduction in Endothelial Cells

2001 • 112 citations

The Effect of AMP-Activated Protein Kinase and Its Activator AICAR on the Metabolism of Human Umbilical Vein Endothelial Cells

1999 • 95 citations

Activation of rat liver AMP‐activated protein kinase by kinase kinase in a purified, reconstituted system

1994 • 85 citations

Hypoxia-induced adrenomedullin production in the kidney

1999 • 84 citations

Regulation of smooth muscle cell migration and integrin expression by the Gax transcription factor

1999 • 82 citations

Amyloid‐β‐induced Degeneration of Human Brain Pericytes Is Dependent on the Apolipoprotein E Genotype

2000 • 51 citations

Cyclin A Downregulation and p21 ^cip1 Upregulation Correlate With GATA-6–Induced Growth Arrest in Glomerular Mesangial Cells

2000 • 31 citations