Adenophostins, newly discovered metabolites of Penicillium brevicompactum, act as potent agonists of the inositol 1,4,5-trisphosphate receptor.

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes

1987 • 676 citations

Solubilization, purification, and characterization of an inositol trisphosphate receptor.

1988 • 650 citations

Ca ²⁺ -Induced Ca ²⁺ Release in Sea Urchin Egg Homogenates: Modulation by Cyclic ADP-Ribose

1991 • 628 citations

Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium.

1987 • 551 citations

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

1982 • 541 citations

Purified inositol 1,4,5-trisphosphate receptor mediates calcium flux in reconstituted lipid vesicles

1989 • 512 citations

Structural Determination of a Cyclic Metabolite of NAD+ with Intracellular Ca2+-mobilizing Activity

1989 • 485 citations

Cyclic ADP-Ribose in Insulin Secretion from Pancreatic βCells

1993 • 447 citations

Competitive, reversible, and potent antagonism of inositol 1,4,5-trisphosphate-activated calcium release by heparin.

1988 • 427 citations

Inositol 1,4,5-trisphosphate activates a channel from smooth muscle sarcoplasmic reticulum

1988 • 399 citations

Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.

1988 • 359 citations

Localization of inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae.

1992 • 345 citations

A cerebellar Purkinje cell marker P400 protein is an inositol 1,4,5-trisphosphate (InsP3) receptor protein. Purification and characterization of InsP3 receptor complex.

1990 • 280 citations

Two polyphosphatidylinositide metabolites control two K+ currents in a neuronal cell

1986 • 268 citations

Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

1992 • 253 citations

IP ₃ Receptor: Localization to Plasma Membrane of T Cells and Cocapping with the T Cell Receptor

1992 • 213 citations

Widespread occurrence in animal tissues of an enzyme catalyzing the conversion of NAD+ into a cyclic metabolite with intracellular Ca2+-mobilizing activity

1989 • 191 citations

Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells

1984 • 190 citations

Comparison of Ca2+ mobilizing activities of cyclic ADP-ribose and inositol trisphosphate.

1990 • 188 citations

Activation of Ca2+ entry into acinar cells by a non-phosphorylatable inositol trisphosphate

1991 • 182 citations

Molecular recognition of inositol polyphosphates by intracellular receptors and metabolic enzymes

1989 • 163 citations

Expressed cerebellar-type inositol 1,4,5-trisphosphate receptor, P400, has calcium release activity in a fibroblast L cell line

1990 • 134 citations

Inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate receptor proteins: isolation and characterization from rat brain.

1991 • 125 citations

Calcium modulation of inositol 1,4,5-trisphosphate-induced calcium release from neuroblastoma x glioma hybrid (NG108-15) microsomes.

1986 • 121 citations

Plasma membrane inositol 1,4,5-trisphosphate receptor of lymphocytes: selective enrichment in sialic acid and unique binding specificity.

1992 • 120 citations

Mechanism of photoinactivation and re-activation in the bioluminescence system of the ctenophore Mnemiopsis

1984 • 111 citations

Synthetic Inositol Trisphosphate Analogs and Their Effects on Phosphatase, Kinase, and the Release of Ca2+

1989 • 94 citations

Specific binding of cyclic ADP-ribose to calcium-storing microsomes from sea urchin eggs

1991 • 89 citations

Tethered IP3. Synthesis and biochemical applications of the 1-O-(3-aminopropyl) ester of inositol (1,4,5)-trisphosphate

1991 • 69 citations

Bradykinin-evoked acetylcholine release via inositol trisphosphate-dependent elevation in free calcium in neuroblastoma x glioma hybrid NG108-15 cells.

1990 • 68 citations

Structural and functional characterization of an inositol polyphosphate receptor from cerebellum.

1992 • 45 citations

Solubilization and separation of inositol 1,3,4,5-tetrakisphosphate- and inositol 1,4,5-trisphosphate-binding proteins and metabolizing enzymes in rat brain

1990 • 42 citations