Critical roles for immunoglobulin translocations and cyclin D dysregulation in multiple myeloma

SEER Cancer Statistics Review, 1975-2003

2006 • 11,387 citations

The RB and p53 pathways in cancer

2002 • 1,612 citations

Multiple myeloma: evolving genetic events and host interactions

2002 • 815 citations

Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells

2002 • 655 citations

Mechanisms of chromosomal translocations in B cell lymphomas

2001 • 623 citations

Chromosome translocations in multiple myeloma

2001 • 481 citations

Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene.

1994 • 460 citations

Cancer: Principles and Practice of Oncology

1990 • 442 citations

Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.

1994 • 432 citations

In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression

2003 • 388 citations

Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation

2002 • 353 citations

Genomic abnormalities in monoclonal gammopathy of undetermined significance

2002 • 351 citations

Diverse karyotypic abnormalities of the c -myc locus associated with c -myc dysregulation and tumor progression in multiple myeloma

2000 • 344 citations

Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors

2001 • 272 citations

Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma

2001 • 224 citations

14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma. Intergroupe Francophone du Myélome.

1999 • 206 citations

Identification of New Nonrandom Translocations in Multiple Myeloma With Multicolor Spectral Karyotyping

1998 • 172 citations

Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablasts

2002 • 156 citations

Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis

2001 • 143 citations

Cyclin D3 Compensates for Loss of Cyclin D2 in Mouse B-lymphocytes Activated via the Antigen Receptor and CD40

2000 • 121 citations

Cytogenetic Abnormalities Correlate with the Plasma Cell Labeling Index and Extent of Bone Marrow Involvement in Myeloma

1999 • 105 citations

Familial Multiple Myeloma: a Family Study and Review of the Literature

2001 • 101 citations

Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma

2001 • 90 citations

Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis

2002 • 64 citations

Alterations of the cyclin D1/pRb/p16INK4A pathway in multiple myeloma

2002 • 62 citations

Multiple Myeloma

2002 • 60 citations

The enigma of ectopic expression of FGFR3 in multiple myeloma: a critical initiating event or just a target for mutational activation during tumor progression

2002 • 37 citations

EXPERIMENTAL PLASMACYTOMAGENESIS IN MICE

1997 • 36 citations