An efficient method for generating proteins with altered enzymatic properties: application to beta-lactamase.

The structure of β-lactamases

1980 • 1,705 citations

A new class of yeast transcriptional activators

1987 • 706 citations

Selective Chemical Catalysis by an Antibody

1986 • 626 citations

Many Random Sequences Functionally Replace the Secretion Signal Sequence of Yeast Invertase

1987 • 375 citations

Bacterial Resistance to β-Lactam Antibiotics: Crystal Structure of β-Lactamase from Staphylococcus aureus PC1 at 2.5 Å Resolution

1987 • 349 citations

Defining the Sequence Specificity of DNA-Binding Proteins by Selecting Binding Sites from Random-Sequence Oligonucleotides: Analysis of Yeast GCN4 Protein

1989 • 333 citations

Combinatorial Cassette Mutagenesis as a Probe of the Informational Content of Protein Sequences

1988 • 326 citations

Kinetic studies on the inactivation of Escherichia coli RTEM β-lactamase by clavulanic acid

1978 • 204 citations

Cloning of random-sequence oligodeoxynucleotides

1986 • 162 citations

A Stereospecific Cyclization Catalyzed by an Antibody

1987 • 128 citations

Contribution of beta-lactamases to bacterial resistance and mechanisms to inhibit beta-lactamases

1985 • 86 citations

[35] The use of random-sequence oligonucleotides for determining consensus sequences

1987 • 63 citations

Defining the consensus sequences ofE.colipromoter elements by random selectio

1988 • 60 citations

Penicillanic acid sulfone: nature of irreversible inactivation of the RTEM .beta.-lactamase from Escherichia coli

1984 • 56 citations

Search for the optimal sequence of the ribosome binding site by random oligonucleotide-directed mutagenesis

1988 • 27 citations

Tertiary and secondary structure analysis of penicillin-binding proteins.

1980 • 9 citations