Critical self-epitopes are key to the understanding of self-tolerance and autoimmunity

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

Immunogenetic Consequences of Vascular Anastomoses Between Bovine Twins

1945 • 1,352 citations

The Specificity of Serological Reactions

1945 • 1,104 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Defining criteria for autoimmune diseases (Witebsky's postulates revisited)

1993 • 781 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization.

1982 • 665 citations

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS

1933 • 629 citations

CHRONIC THYROIDITIS AND AUTOIMMUNIZATION

1957 • 535 citations

Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

1991 • 485 citations

Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.

1987 • 473 citations

Polyspecificity of Monoclonal Lupus Autoantibodies Produced by Human-Human Hybridomas

1983 • 453 citations

Studies on organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts.

1956 • 390 citations

High frequency of natural autoantibodies in normal newborn mice.

1985 • 387 citations

The Immunologic Theory of Aging

1971 • 363 citations

The Collected Papers of Paul Ehrlich

2013 • 363 citations

Systemic autoimmune disease arises from polyclonal B cell activation.

1987 • 314 citations

Natural Antibodies and the Immune Response

1966 • 312 citations

Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens.

1983 • 303 citations

Studies on Organ Specificity

1956 • 285 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

Reactions among IgM antibodies derived from normal, neonatal mice

1984 • 231 citations

Production of autoantibodies by human-human hybridomas.

1982 • 228 citations

Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to Coxsackievirus B3-induced myocarditis.

1987 • 224 citations

VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities.

1992 • 214 citations

Human Antibody Fragments Specific for Human Blood Group Antigens from a Phage Display Library

1993 • 203 citations

Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides: identificantion of circulating DNA and renal localization of DNA-anti-DNA complexes.

1977 • 194 citations

Thirty-six human monoclonal immunoglobulins with antibody activity against cytoskeleton proteins, thyroglobulin, and native DNA: immunologic studies and clinical correlations

1983 • 193 citations

Large numbers of cells in normal mice produce antibody components of isologous erythrocytes

1974 • 178 citations

Naturally occurring antibodies against nine common antigens in humans sera. II. High incidence of monoclonal Ig exhibiting antibody activity against actin and tubulin and sharing antibody specificities with natural antibodies.

1982 • 177 citations

The immunologic theory of aging

1970 • 168 citations

Human Monoclonal Autoantibodies That React with Multiple Endocrine Organs

1983 • 145 citations

Anti-DNA autoantibodies in (NZB X NZW)F1 mice are clonally heterogeneous, but the majority share a common idiotype.

1982 • 143 citations

Multiple organ-reactive monoclonal autoantibodies

1983 • 142 citations

A high frequency idiotypic marker of anti-DNA autoantibodies in MRL-Ipr/Ipr mice.

1982 • 139 citations

Anti-DNA autoantibody-producing hybridomas of normal human lymphoid cell origin.

1984 • 135 citations

Z-DNA-specific antibodies in human systemic lupus erythematosus.

1983 • 127 citations

Naturally occurring autoantibodies to skeletal proteins from human red blood cells.

1982 • 110 citations

Specificity of natural serum antibodies present in phylogenetically distinct fish species.

1988 • 107 citations

Selection of Immunoglobulin Variable Regions in Autoimmunity to DNA

1992 • 107 citations

Natural Autoantibodies Constitute a Substantial Part of Normal Circulating Immunoglobulins

1986 • 107 citations

Autoimmunity: polyclonal activation or antigen induction?

1988 • 98 citations

A high incidence of cross‐reactive idiotypes among murine natural autoantibodies

1985 • 90 citations

Antibodies reactive with cell surface carbohydrates.

1975 • 81 citations

A NATURAL ANTIBODY THAT REACTS IN VITRO WITH A SEDIMENTABLE CONSTITUENT OF NORMAL TISSUE CELLS

1942 • 75 citations

CRC Handbook Series in Clinical Laboratory Science

1979 • 67 citations

Mechanism for induction of anti-DNA antibodies by bacterial lipopolysaccharides in mice. I. Anti-DNA induction by LPS without significant release of DNA in circulating blood.

1977 • 64 citations

Human anti-Gal heavy chain genes. Preferential use of VH3 and the presence of somatic mutations.

1995 • 62 citations

Epitopes on Thyroglobulin: A Study of Patients with Thyroid Disease

1994 • 51 citations

The Specificity of Serological Reactions (Revised Edition)

1964 • 46 citations

Thymus reactive IgM autoantibodies in normal mouse sera

1975 • 44 citations

Mechanism for Induction of Anti-DNA Antibodies by Bacterial Lipopolysaccharides in Mice

1977 • 41 citations

Interspecies brain antigen detected by naturally occurring mouse anti-brain autoantibody.

1975 • 40 citations

Autoantigenic determinants on human thyroglobulin

1990 • 39 citations

Intrastrain recurrent idiotypes among anti‐DNA antibodies of (NZB X NZW)F₁ hybrid mice

1982 • 38 citations

Natural Autoantibodies, Tolerance, and Autoimmunity

1997 • 36 citations

Natural autoantibodies to the fore — forbidden clones to the rear?

1983 • 32 citations

Does Immunological Tolerance Explain the Waste in the B‐Lymphocyte Immune System? Experiment and Theory^a

1995 • 25 citations

Autoimmunity: The Fas track

1995 • 22 citations

Relationship of a Hemolysin Resembling Anti‐Tj^a to Threatened Abortion in Western Australia

1964 • 16 citations

Detection of private and recurrent idiotopes on natural anti-tubulin antibodies by monoclonal anti-idiotopic antibodies.

1988 • 12 citations

FISH on purified extrachromosomal DNA molecules

1999 • 7 citations