IGFs and IGFBPs: role in health and disease

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 • 2,010 citations

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

1998 • 1,850 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

1999 • 1,128 citations

Intrauterine Growth Retardation and Postnatal Growth Failure Associated with Deletion of the Insulin-Like Growth Factor I Gene

1996 • 1,094 citations

Insulin‐like growth factors I and II

1990 • 1,006 citations

Fetal and Neonatal Physiology

1989 • 901 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 644 citations

Insulin-Like Growth Factor 1 and Prostate Cancer Risk: A Population-Based, Case-Control Study

1998 • 592 citations

Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis

1999 • 558 citations

Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis

2000 • 511 citations

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

1992 • 478 citations

Acromegaly

1990 • 422 citations

Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth.

1995 • 361 citations

Insulin-Like Growth Factor Binding Proteins in the Human Circulation: A Review

1994 • 346 citations

Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis

2000 • 320 citations

The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene.

1995 • 318 citations

Angiogenesis in the Corpus Luteum

2000 • 303 citations

The Role of the Insulin-like Growth Factor System in Human Cancer

1996 • 295 citations

Recombinant Human Insulin-Like Growth Factor I Increases Insulin Sensitivity and Improves Glycemic Control in Type II Diabetes

1996 • 283 citations

Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease

1994 • 273 citations

Insulin-like Growth Factor-binding Protein (IGFBP)-3 and IGFBP-5 Share a Common Nuclear Transport Pathway in T47D Human Breast Carcinoma Cells

1998 • 269 citations

C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight

1993 • 229 citations

Insulin-like growth factors I and II in evaluation of growth retardation

1986 • 220 citations

Placental Growth Hormone Levels in Normal Pregnancy and in Pregnancies with Intrauterine Growth Retardation

1993 • 196 citations

Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome).

1993 • 196 citations

Expression of Insulin-Like Growth Factor I Stimulates Normal Somatic Growth in Growth Hormone-Deficient Transgenic Mice

1990 • 195 citations

Effect of Diabetes and its Control on Insulin-like Growth Factors in the Young Subject with Type I Diabetes

1984 • 189 citations

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma

1992 • 189 citations

Localization of insulin-like growth factor genes to human chromosomes 11 and 12

1984 • 180 citations

Congenital idiopathic growth hormone deficiency associated with prenatal and early postnatal growth failure

1992 • 167 citations

Increased Levels of Insulin-Like Growth Factor II (IGF-II) and IGF-Binding Protein-2 Are Associated with Malignancy in Sporadic Adrenocortical Tumors¹

1998 • 165 citations

Effects of Dose and Gender on the Growth and Growth Factor Response to GH in GH-Deficient Children: Implications for Efficacy and Safety

2002 • 164 citations

Genetics, Chemistry, and Function of the IGF/IGFBP System

2000 • 163 citations

Does the GH–IGF axis play a role in cancer pathogenesis?

2000 • 156 citations

Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth

1995 • 154 citations

Growth Hormone Treatment of Children with Brain Tumors and Risk of Tumor Recurrence1

2000 • 148 citations

Growth Hormone Treatment of Short Children Born Small for Gestational Age: Growth Responses with Continuous and Discontinuous Regimens Over 6 Years¹

2000 • 138 citations

Novel Aspects of the Insulin-like Growth Factor Binding Proteins

1999 • 136 citations

Intravitreal growth factors in proliferative diabetic retinopathy: correlation with neovascular activity and glycaemic management

1997 • 130 citations

The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene

1995 • 123 citations

Insulin-like Growth Factors Reverse or Arrest Diabetic Neuropathy: Effects on Hyperalgesia and Impaired Nerve Regeneration in Rats

1996 • 115 citations

Increased Levels of Insulin-Like Growth Factor II (IGF-II) and IGF-Binding Protein-2 Are Associated with Malignancy in Sporadic Adrenocortical Tumors

1998 • 114 citations

Abnormal Regulation of Insulin-Like Growth Factor Binding Proteins in Adolescents with Insulin-Dependent Diabetes*

1991 • 112 citations

Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome)

1993 • 106 citations

Obesity, Weight Change, Fasting Insulin, Proinsulin, C-Peptide, and Insulin-like Growth Factor-1 Levels in Women with and without Breast Cancer: The Rancho Bernardo Study

1999 • 106 citations

Prostatic Hyperplasia: An Unknown Feature of Acromegaly

1998 • 104 citations

High-Dose Growth Hormone (GH) Treatment in Non-GH-Deficient Children Born Small for Gestational Age Induces Growth Responses Related to Pretreatment GH Secretion and Associated with a Reversible Decrease in Insulin Sensitivity

2002 • 102 citations

Clinical aspects of insulin-like growth factor binding proteins.

1991 • 101 citations

Growth Hormone Treatment of Children with Brain Tumors and Risk of Tumor Recurrence

2000 • 100 citations

Usefulness of Different Biochemical Markers of the Insulin-Like Growth Factor (IGF) Family in Diagnosing Growth Hormone Excess and Deficiency in Adults¹

2001 • 98 citations

Contribution of Growth Hormone and IGF-I to Early Diabetic Nephropathy in Type 1 Diabetes

1998 • 95 citations

Colon Polyps in Acromegaly

1991 • 93 citations

Insulin-Like Growth Factor-I in Diabetes Mellitus: Its Physiology, Metabolic Effects, and Potential Clinical Utility

2000 • 91 citations

Cotherapy with recombinant human insulin-like growth factor I and insulin improves glycemic control in type 1 diabetes. RhIGF-I in IDDM Study Group.

1999 • 89 citations

Growth Hormone Treatment of Short Children Born Small for Gestational Age: Growth Responses with Continuous and Discontinuous Regimens Over 6 Years

2000 • 89 citations

Dose titration and patient selection increases the efficacy of GH replacement in severely GH deficient adults

1999 • 85 citations

Increased prevalence of colonic polyps and altered lymphocyte subset pattern in the colonic lamina propria in acromegaly

1997 • 84 citations

Acid-Labile Subunit of Human Insulin-Like Growth Factor-Binding Protein Complex: Measurement, Molecular, and Clinical Evaluation

1997 • 83 citations

The Relationship between Serum GH and Serum IGF-I in Acromegaly Is Gender-Specific

2001 • 81 citations

Lack of increased risk for extracranial, nonleukemic neoplasms in recipients of recombinant deoxyribonucleic acid growth hormone.

1995 • 79 citations

The effects of recombinant insulin-like growth factor I administration on growth hormone levels and insulin requirements in adolescents with Type 1 (insulin-dependent) diabetes mellitus

1993 • 78 citations

Diminished growth hormone-binding protein in children with insulin-dependent diabetes mellitus

1992 • 74 citations

Growth hormone treatment of short children born small‐for‐gestational‐age: the Nordic Multicentre Trial

1998 • 73 citations

Free and Total Insulin-Like Growth Factor I (IGF-I), IGF-Binding Protein-1 (IGFBP-1), and IGFBP-3 and Their Relationships to the Presence of Diabetic Retinopathy and Glomerular Hyperfiltration in Insulin-Dependent Diabetes Mellitus¹

1997 • 70 citations

Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes

1996 • 69 citations

Increased birth weights of National Wilms' Tumor Study patients suggest a growth factor excess.

1994 • 66 citations

Early Reduction in Insulin-like Growth Factor Gene Expression in Diabetic Nerve

1994 • 65 citations

Usefulness of Different Biochemical Markers of the Insulin-Like Growth Factor (IGF) Family in Diagnosing Growth Hormone Excess and Deficiency in Adults

2001 • 64 citations

Monitoring serum insulin‐like growth factor‐I (IGF‐I), IGF binding protein‐3 (IGFBP‐3), IGF‐I/IGFBP‐3 molar ratio and leptin during growth hormone treatment for disordered growth

2000 • 62 citations

Insulin-like growth factor–binding protein-3 and breast cancer survival

1998 • 61 citations

Serum insulin‐like growth factor‐1 is not a useful marker of prostate cancer

1999 • 61 citations

Does acromegaly really predispose to an increased prevalence of gastrointestinal tumours?

1994 • 61 citations

Insulin‐like Growth Factor‐I and IGF‐I Receptors in Diabetic Patients with Neuropathy

1995 • 60 citations

Insulin‐like growth factor binding proteins and their regulation

1994 • 57 citations

Effect of diabetes and its control on insulin-like growth factors in the young subject with type I diabetes

1984 • 55 citations

Abnormally Large Placenta Associated with Beckwith-Wiedemann Syndrome

1986 • 54 citations

The significance of serum levels of insulin‐like growth factor‐1 in patients with prostate cancer

2000 • 52 citations

Insulin therapy and GH-IGF-I axis disorders in diabetes: impact of glycaemic control and hepatic insulinization.

1996 • 52 citations

Physiologic and clinical relevance of the insulin-like growth factor binding proteins

1994 • 51 citations

The Effects of Repeated Daily Recombinant Human Insulin‐like Growth Factor I Administration in Adolescents with Type 1 Diabetes

1995 • 48 citations

Diminished growth hormone-binding protein in children with insulin- dependent diabetes mellitus

1992 • 47 citations

The effects of subcutaneous insulin-like growth factor-I infusion in insulin-dependent diabetes mellitus.

1994 • 47 citations

Does Insulin-Like Growth Factor I Predict Incidence and Progression of Diabetic Retinopathy?

1995 • 46 citations

Effects of Dose and Gender on the Growth and Growth Factor Response to GH in GH-Deficient Children: Implications for Efficacy and Safety

2002 • 46 citations

Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats

1991 • 46 citations

Free and Total Insulin-Like Growth Factor I (IGF-I), IGF-Binding Protein-1 (IGFBP-1), and IGFBP-3 and Their Relationships to the Presence of Diabetic Retinopathy and Glomerular Hyperfiltration in Insulin-Dependent Diabetes Mellitus

1997 • 46 citations

Diagnostic Value of the Acid-Labile Subunit in Acromegaly: Evaluation in Comparison with Insulin-Like Growth Factor (IGF) I, and IGF-Binding Protein-1, -2, and -3¹

2001 • 42 citations

Acid-Labile Subunit of Human Insulin-Like Growth Factor-Binding Protein Complex: Measurement, Molecular, and Clinical Evaluation

1997 • 41 citations

IGFs and Human Cancer: Implications Regarding the Risk of Growth Hormone Therapy

1999 • 40 citations

High-Dose Growth Hormone (GH) Treatment in Non-GH-Deficient Children Born Small for Gestational Age Induces Growth Responses Related to Pretreatment GH Secretion and Associated with a Reversible Decrease in Insulin Sensitivity

2002 • 36 citations

Individualizing Growth Hormone Dosing in Children

2001 • 36 citations

Dual Hormonal Replacement Therapy with Insulin and Recombinant Human Insulin-Like Growth Factor (IGF)-I in Insulin-Dependent Diabetes Mellitus: Effects on the Growth Hormone/IGF/IGF-Binding Protein System*

1997 • 34 citations

Prostatic Hyperplasia: An Unknown Feature of Acromegaly

1998 • 34 citations

Brain Insulin‐Like Growth Factor‐II mRNA Content Is Reduced in Insulin‐Dependent and Non‐Insulin‐Dependent Diabetes Mellitus

1996 • 31 citations

Insulin-like growth factor I (IGF-I) delays the onset of diabetes in non-obese diabetic (NOD) mice

1996 • 30 citations

Recombinant insulin-like growth factor I normalizes expression of renal glucose transporters in diabetic rats

1997 • 27 citations

Lack of increased risk for extracranial, nonleukemic neoplasms in recipients of recombinant deoxyribonucleic acid growth hormone

1995 • 26 citations

Contribution of growth hormone and IGF-I to early diabetic nephropathy in type 1 diabetes

1998 • 26 citations

Does insulin-like growth factor I predict incidence and progression of diabetic retinopathy?

1995 • 25 citations

Diagnostic Value of the Acid-Labile Subunit in Acromegaly: Evaluation in Comparison with Insulin-Like Growth Factor (IGF) I, and IGF-Binding Protein-1, -2, and -3

2001 • 24 citations

Dual Hormonal Replacement Therapy with Insulin and Recombinant Human Insulin-Like Growth Factor (IGF)-I in Insulin-Dependent Diabetes Mellitus: Effects on the Growth Hormone/IGF/IGF-Binding Protein System

1997 • 24 citations

Regional changes in the intrarenal insulin-like growth factor-I axis in diabetes

1997 • 23 citations

Acromegaly and colon cancer

2000 • 22 citations

Insulin-like growth factors (IGF) and IGF-binding proteins: their use for diagnosis of growth hormone deficiency

2000 • 22 citations

Growth Hormone in Adults: Physiological and Clinical Aspects

2000 • 22 citations

The effects of subcutaneous insulin-like growth factor-I infusion in insulin-dependent diabetes mellitus

1994 • 21 citations

Regulation of GH Secretion in Acromegaly: Reproducibility of Daily GH Profiles and Attenuated Negative Feedback by IGF-I

2001 • 20 citations

The Relationship between Serum GH and Serum IGF-I in Acromegaly Is Gender-Specific

2001 • 20 citations

Characterization of the insulin-like growth factors (IGF) axis in a cultured mouse Leydig cell line (TM-3).

1995 • 19 citations

Growth Hormone in Adults: Physiological and Clinical Aspects

1997 • 14 citations

Regulation of GH Secretion in Acromegaly: Reproducibility of Daily GH Profiles and Attenuated Negative Feedback by IGF-I

2001 • 6 citations