Coley's toxins, tumor necrosis factor and cancer research: A historical perspective

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

The Concept of Immunological Surveillance

2015 • 1,586 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Severe Group A Streptococcal Infections Associated with a Toxic Shock-like Syndrome and Scarlet Fever Toxin A

1989 • 1,236 citations

THE TREATMENT OF MALIGNAT TUMORS BY REPEATED INOCULATIONS OF ERYSIPELAS

1893 • 946 citations

The Natural History of Initially Untreated Low-Grade Non-Hodgkin's Lymphomas

1984 • 922 citations

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma.

1992 • 730 citations

Spontaneous Regression of Cancer

1966 • 702 citations

CONTRIBUTION TO THE KNOWLEDGE OF SARCOMA

1891 • 656 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

1992 • 595 citations

Clinical and Bacteriologic Observations of a Toxic Shock–like Syndrome Due toStreptococcus pyogenes

1987 • 581 citations

Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess

1987 • 539 citations

Kupffer Cells and Other Liver Sinusoidal Cells

1978 • 434 citations

Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression.

1991 • 429 citations

The Treatment of Inoperable Sarcoma by Bacterial Toxins (the Mixed Toxins of the Streptococcus erysipelas and the Bacillus prodigiosus).

1910 • 405 citations

Endotoxin Promotes the Translocation of Bacteria From the Gut

1987 • 403 citations

Interleukin‐1α and Interleukin‐1 β in Preterm and Term Human Parturition

1992 • 390 citations

In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

1990 • 370 citations

Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide.

1993 • 352 citations

Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.

1990 • 312 citations

MALIGNANT TUMORS ARISING DE NOVO IN IMMUNOSUPPRESSED ORGAN TRANSPLANT RECIPIENTS

1972 • 305 citations

A Single Dose of Endotoxin Increases Intestinal Permeability in Healthy Humans

1988 • 302 citations

Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor.

1988 • 300 citations

Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo.

1987 • 292 citations

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors.

1991 • 283 citations

Simple Intestinal Obstruction Causes Bacterial Translocation in Man

1989 • 282 citations

The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity.

1988 • 276 citations

Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production

1989 • 274 citations

The treatment of malignant tumors by bacterial toxins as developed by the late William B. Coley, M.D., reviewed in the light of modern research.

1946 • 274 citations

Epstein-Barr virus-encoded protein found in plasma membranes of transformed cells

1985 • 274 citations

Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.

1988 • 260 citations

A review of the influence of bacterial infection and of bacterial products (Coley's toxins) on malignant tumors in man; a critical analysis of 30 inoperable cases treated by Coley's mixed toxins, in which diagnosis was confirmed by microscopic examination selected for special study.

1953 • 244 citations

Active specific immunotherapy for melanoma: phase I trial of allogeneic lysates and a novel adjuvant.

1988 • 239 citations

Tumors of the Immunocompromised Patient

1988 • 221 citations

RELATION OF RENAL IMPAIRMENT AND HAEMORRHAGIC DIATHESIS TO ENDOTOXAEMIA IN FULMINANT HEPATIC FAILURE

1974 • 213 citations

The natural interleukin-1 receptor antagonist prevents interleukin-l-induced preterm delivery in mice

1992 • 212 citations

Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons.

1986 • 211 citations

Regression of bladder tumors in mice treated with interleukin 2 gene-modified tumor cells.

1993 • 210 citations

Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model

1993 • 208 citations

Tumour necrosis factor in man: Clinical and biological observations

1987 • 205 citations

AIDS-Related Malignancies: the Emerging Epidemic

1993 • 204 citations

Enhancement of experimental metastasis by tumor necrosis factor.

1993 • 198 citations

Mechanisms of endotoxin shock and endotoxin hypersensitivity

1993 • 197 citations

Serum-free in vitro bioassay for the detection of tumor necrosis factor

1986 • 195 citations

Streptococcal Toxic Shock Syndrome: Synthesis of Tumor Necrosis Factor and Interleukin-1 by Monocytes Stimulated with Pyrogenic Exotoxin A and Streptolysin O

1992 • 194 citations

Endotoxaemia and renal failure in cirrhosis and obstructive jaundice.

1976 • 179 citations

Basic and Clinical Immunology

1983 • 179 citations

A PURIFIED GROUP A STREPTOCOCCAL PYROGENIC EXOTOXIN

1970 • 174 citations

Macrophage response to bacteria: induction of marked secretory and cellular activities by lipoteichoic acids

1992 • 168 citations

Increased Intestinal Permeability in Endotoxic Pigs

1991 • 161 citations

The reticuloendothelial system and the pathogenesis of liver disease

1981 • 154 citations

Prediction of successful embryo implantation by measuring interleukin-1-alpha and immunosuppressive factor(s) in preimplantation embryo culture fluid

1991 • 148 citations

Regression of Metastatic Renal Cell Carcinoma After Cytoreductive Nephrectomy

1993 • 144 citations

Transmission of a Malignant New Growth by Means of a Cell-Free Filtrate

1983 • 143 citations

Tumor necrosis factors: The molecules and their emerging role in medicine

1992 • 138 citations

Medical Microbiology: An Introduction to Infectious Diseases

1992 • 133 citations

POSSIBLE PATHOGENIC ROLE OF ENDOTOXIN IN REYE'S SYNDROME

1975 • 132 citations

Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents.

1987 • 132 citations

FROST REVISITED: THE MODERN EPIDEMIOLOGY OF TUBERCULOSIS

1975 • 131 citations

Activity of intrapleural recombinant gamma-interferon in malignant mesothelioma

1991 • 130 citations

Geographic and Temporal Distribution and Molecular Characterization of Two Highly Pathogenic Clones ofStreptococcus pyogenesExpressing Allelic Variants of Pyrogenic Exotoxin A (Scarlet Fever Toxin)

1993 • 129 citations

ENDOTOXÆMIA IN MAN

1972 • 129 citations

Similarities of the Anti-tumour Actions of Endotoxin, Lipid A and Double-stranded RNA

1973 • 127 citations

Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α

1990 • 124 citations

Production of tumor necrosis factor alpha by monocytes from patients with pulmonary tuberculosis

1990 • 124 citations

Synergistic cytotoxic and antitumor effects of recombinant human tumor necrosis factor and hyperthermia.

1988 • 124 citations

The effect of Mycobacterium tuberculosis (BCG) infection on the resistance of mice to bacterial endotoxin and Salmonella enteritidis infection.

1959 • 121 citations

Localization of tumour necrosis factor production in cells at the materno/fetal interface in human pregnancy

1992 • 121 citations

Immunosuppression and Cancer

1969 • 118 citations

Pathogenesis of the toxic shock syndrome: T cell mediated lethal shock caused by the superantigen TSST‐1

1993 • 117 citations

Phase I trial of intravenously administered endotoxin (Salmonella abortus equi) in cancer patients.

1991 • 115 citations

Superantigens Associated with Staphylococcal and Streptococcal Toxic Shock Syndrome are Potent Inducers of Tumor Necrosis Factor- Synthesis

1993 • 114 citations

Role of serum endotoxin and antiendotoxin core antibody levels in predicting the development of multiple organ failure in acute pancreatitis

1993 • 113 citations

Cellular mechanisms of the antitumor activity of recombinant IL-6 in mice.

1992 • 111 citations

The immunological basis of endotoxin-induced tumor regression. Requirement for T-cell-mediated immunity.

1978 • 111 citations

Production of Tumor Necrosis Factor by Human Monocytes in Response to Toxic-Shock-Syndrome Toxin-1

1988 • 108 citations

TREATMENT OF INOPERABLE MALIGNANT TUMORS WITH THE TOXINES OF ERYSIPELAS AND THE BACILLUS PRODIGIOSUS

1894 • 106 citations

Bacterial translocation after thermal injury

1993 • 102 citations

ENDOTOXÆMIA IN MAN

1972 • 101 citations

Stimulation of human T cells by streptococcal "superantigen" erythrogenic toxins (scarlet fever toxins).

1993 • 94 citations

Cytokine down-regulation in endotoxin tolerance.

1993 • 93 citations

Alteration of Immune Function by Staphylococcal Pyrogenic Exotoxin Type C: Possible Role in Toxic-Shock Syndrome

1983 • 90 citations

Synergistic antitumor effects of immunotherapy with recombinant interleukin-2 and recombinant tumor necrosis factor-alpha.

1988 • 86 citations

Recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) given as daily short infusions – a phase I dose-toxicity study

1989 • 85 citations

Studies on the Mechanisms Involved in the Production of Abortion by Endotoxin

1960 • 84 citations

The immunological basis of endotoxin-induced tumor regression. Requirement for a pre-existing state of concomitant anti-tumor immunity.

1978 • 83 citations

Interferon-alpha therapy of renal cancer.

1984 • 83 citations

Production of Pyrogenic Exotoxin by Groups of Streptococci: Association with Group A

1979 • 83 citations

Lymphocytes binding and T cell mitogenic properties of group A streptococcal lipoteichoic acid.

1979 • 80 citations

Ueber die Züchtung der Erysipelkokken auf künstlichem Nährboden und ihre Uebertragbarkeit auf den Menschen

1882 • 79 citations

Group A streptococcal pyrogenic exotoxin: pyrogenicity, alteration of blood-brain barrier, and separation of sites for pyrogenicity and enhancement of lethal endotoxin shock

1978 • 79 citations

Biological response to intravenously administered endotoxin in patients with advanced cancer.

1990 • 77 citations

Interleukin 1-induced, T cell-mediated regression of immunogenic murine tumors. Requirement for an adequate level of already acquired host concomitant immunity.

1988 • 77 citations

Immunosuppression and cancer.

1972 • 77 citations

The acute-phase response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-α

1992 • 72 citations

Analysis of enteropathy induced by tumour necrosis factor α

1993 • 71 citations

Tumor Necrosis Factor-∝ Induces Interleukin-1∝ and Interleukin-1 Receptor Antagonist Production by Cultured Human Keratinocytes

1993 • 71 citations

THE TREATMENT OF INOPERABLE SARCOMA WITH THE 'MIXED TOXINS OF ERYSIPELAS AND BACILLUS PRODIGIOSUS.

1898 • 69 citations

Effect of intraperitoneal recombinant human tumour necrosis factor alpha on malignant ascites

1991 • 69 citations

Streptococcal Toxic Shock Syndrome

1990 • 69 citations

Fluid replacement protection of rabbits challenged subcutaneous with toxic shock syndrome toxins

1991 • 68 citations

Antitumor effects of alpha-interferon and gamma-interferon on a murine renal cancer (Renca) in vitro and in vivo.

1990 • 65 citations

Interleukin-2 treatment in lymphoma: a phase II multicenter study [see comments]

1994 • 64 citations

Hyperreactivity to endotoxin in mice infected with mycobacteria. Induction and elicitation of the reactions.

1961 • 64 citations

Fatal heat stroke. Circulating endotoxin and gram-negative sepsis as complications

1971 • 64 citations

Combination cytokine immunotherapy with tumor necrosis factor alpha, interleukin 2, and alpha-interferon and its synergistic antitumor effects in mice.

1989 • 62 citations

THE THERAPEUTIC VALUE OF THE MIXED TOXINS OF THE STREPTOCOCCUS OF ERYSIPELAS AND BACILLUS PRODIGIOSUS IN THE TREATEMENT OF INOPER- ABLE MALIGNANT TUMORS

1896 • 61 citations

Cure of B16F10 melanoma lung metastasis in mice by chronic indomethacin therapy combined with repeated rounds of interleukin 2: characteristics of killer cells generated in situ.

1988 • 60 citations

Endotoxin and staphylococcus aureus enterotoxin a induce different patterns of cytokines

1992 • 60 citations

A phase I trial of recombinant human tumor necrosis factor and interferon-gamma: effects of combination cytokine administration in vivo.

1989 • 58 citations

Significance of endotoxaemia in experimental "galactosamine-hepatitis" in the rat.

1977 • 57 citations

Evidence for the Involvement of Endotoxin in Toxic Shock Syndrome

1987 • 56 citations

Cytokines and cancer: experimental systems

1991 • 56 citations

Chemotherapy‐induced differential changes in lymphocyte subsets and natural‐killer‐cell function in patients with advanced breast cancer

1993 • 55 citations

Tumor necrosis factor as an autocrine growth factor for neuroblastoma.

1992 • 53 citations

Lymphocyte Binding and T Cell Mitogenic Properties of Group A Streptococcal Lipoteichoic Acid

1979 • 52 citations

Bacterial Infections of Humans: Epidemiology and Control

1991 • 51 citations

Modulating activity of interferon-gamma on endotoxin-induced cytokine production in cancer patients

1991 • 51 citations

Prevention of endotoxaemia by non-absorbable antibiotics in heat stress.

1987 • 51 citations

Soluble TNF receptors in amniotic fluid and in urine from pregnant women

1992 • 51 citations

Antibodies to endotoxin core in sudden infant death syndrome.

1994 • 50 citations

Prolonged, continuous treatment of hairy cell leukemia patients with recombinant interferon-alpha 2a.

1991 • 49 citations

Keratinocyte Cytokines and Growth Factors: Functions in Skin Immunity and Homeostasis

1990 • 48 citations

Numbers of host "helper" T cells and proliferating cells predict survival in diffuse small-cell lymphomas.

1989 • 48 citations

Growing tumors induce hypersensitivity to endotoxin and tumor necrosis factor

1987 • 46 citations

Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity

1991 • 45 citations

Reflex Vasodilatation Test in Patients with Periarthrosis Humero‐Scapularis and the »Shoulder‐Hand Syndrome».

1953 • 45 citations

THE TREATMENT OF CANCER

1913 • 43 citations

Fever and the immune response. The effects of physiological temperatures on primary murine splenic T-cell responses in vitro.

1993 • 43 citations

The use of lipoteichoic acid (LTA) from Streptococcus pyogenes to induce a serum factor causing tumour necrosis

1985 • 40 citations

A comparison of intestinal permeability between humans and three common laboratory animals

1987 • 39 citations

In vitroproduction of tumour necrosis factor and prostaglandin E2 by peripheral blood mononuclear cells from tuberculosis patients

1990 • 38 citations

Synergistic induction of interleukin-1 by endotoxin and toxic shock syndrome toxin-1 using rat macrophages

1987 • 38 citations

Secretion of tumor necrosis factor during fetal and neonatal development of the mouse: ontogenic inflammation.

1989 • 37 citations

lnterleukin-2: Solid-Tumor Therapy

1994 • 37 citations

Increased antitumor effect of immunoconjugates and tumor necrosis factor in vivo.

1988 • 35 citations

Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma

1988 • 35 citations

The in vivo Anti‐tumor Effect of Human Recombinant Interleukin‐6

1990 • 34 citations

Antitumor activity of recombinant human tumor necrosis factor in combination with hyperthermia, chemotherapy, or immunotherapy.

1987 • 33 citations

Clinical effect of Coley's toxin. II. A seven-year study.

1962 • 33 citations

Inhibition of ribonucleic acid synthesis by group A streptococcal pyrogenic exotoxin

1980 • 33 citations

Embryonic resistance to tumour necrosis factor-α mediated cytotoxicity: novel mechanism underlying maternal immunological tolerance to the fetal allograft

1993 • 32 citations

THE TREATMENT OF INOPERABLE SARCOMA WITH THE MIXED TOXINS OF ERYSIPELAS AND BACILLUS PRODIGIOSUS.

1898 • 32 citations

Bacillus Calmette-Gu�rin potentiates monocyte responses to lipopolysaccharide-induced tumor necrosis factor and interleukin-1, but not interleukin-6 in bladder cancer patients

1994 • 30 citations

Attenuation of endotoxin-induced intestinal microcirculatory damage by eicosapentanoic acid

1993 • 30 citations

END RESULTS IN HODGKINʼS DISEASE AND LYMPHOSARCOMA TREATED BY THE MIXED TOXINS OF ERYSIPElAS AND BACILLUS PRODIGIOSUS, ALONIS OR COMBINED WITH RADIATION

1928 • 29 citations

Phase II Trial of Recombinant Tumor Necrosis Factor in Disseminated Malignant Melanoma

1992 • 29 citations

The Reaction of Mice and of Various Mouse Tumors to the Injection of Bacterial Products

1936 • 28 citations

Phase I Trial of Recombinant Macrophage Colony-Stimulating Factor by Rapid Intravenous Infusion in Patients with Cancer

1992 • 27 citations

Intestinal bacterial flora, intestinal pathology, and lipopolysaccharide-induced translocation of intestinal bacteria.

1992 • 27 citations

Eradication of spontaneous and experimental adenocarcinoma metastases with chronic indomethacin and intermittent IL‐2 therapy

1993 • 27 citations

Polymorphism of the mouse TNF-i locus: sequence studies of the 3'-untranslated region and first intron

1993 • 25 citations

Hyperreactivity to Endotoxin after Infection with BCG

1964 • 25 citations

Mixed bacterial toxins in the treatment of tumors. IV. Response of methylcholanthrene-induced, spontaneous, and transplanted tumors in mice.

1961 • 25 citations

Growth factors and their receptors in development

1993 • 25 citations

Tumor Necrosis Factor Induces Hemorrhagic Necrosis of a Sarcoma

1989 • 23 citations

Intrapleural application of recombinant interleukin-2 in patients with malignant pleurisy due to lung cancer

1991 • 22 citations

The Diagnosis and Treatment of Bone Sarcoma.

1936 • 22 citations

Combination immunotherapy of cancer in a mouse model: synergism between tumor necrosis factor and other defense systems.

1987 • 22 citations

Possible mediators in endotoxin-induced abortion

1990 • 22 citations

Sarcoma Of The Long Bones

1907 • 20 citations

Role of the intestinal flora in clearance and detoxification of circulating endotoxin.

1973 • 20 citations

The Treatment of Sarcoma with the Mixed Toxins of Erysipelas and Bacillus Prodigiosus

1908 • 20 citations

Mixed bacterial toxins in the treatment of tumors. I. Methods of preparation and effects on normal and sarcoma 37-bearing mice.

1958 • 19 citations

Antitumor response independent of functional B or T lymphocytes induced by the local and sustained release of interleukin-2 by the tumor cells

1993 • 19 citations

Induction of Circulating Phospholipase A2 Activity by Intravenous Infusion of Endotoxin in Patients with Neoplasia

1992 • 18 citations

Genetics, the Immune Response and Oncogenesis

1976 • 18 citations

ERYSIPELAS

1913 • 16 citations

Protective effect of E3330, a novel quinone derivative, in galactosamine-induced hepatitis in rats.

1993 • 16 citations

CANCER OF THE TESTIS

1915 • 15 citations

Endothelial myeloma or Ewing's sarcoma

1935 • 15 citations

Effect of the mixed bacterial vaccine on the immune response of patients with non-small cell lung cancer and refractory malignancies

1988 • 14 citations

SARCOMA OF THE LONG BONES

1907 • 13 citations

An apparent recovery from multiple sarcoma

1928 • 12 citations

TREATMENT OF CANCER BY BACTERIAL TOXINS.

1965 • 12 citations

Possible role for cytotoxic lymphocytes in the pathogenesis of acute interstitial nephritis after recombinant interleukin-2 treatment for renal cell cancer

1993 • 12 citations

The Effect of Heterologous Bacterial Products Upon Tuberculous Animals

1936 • 12 citations

Treatment of bone sarcoma.

1971 • 11 citations

Clinical results and immunologic effects of a mixed bacterial vaccine in cancer patients

1993 • 11 citations

Involvement of platelet-activating factor (PAF) in endotoxin- or ischaemia-induced intestinal hyperpermeability in the rat.

1993 • 11 citations

A novel Mutein of TNFα Containing the Arg‐Gly‐Asp Sequence Shows Reduced Toxicity in Intestine

1994 • 11 citations

Beneficial effects of post-transfusional hepatitis in acute myelogenous leukemia may be mediated by lipopolysaccharides, tumor necrosis factor alpha and interferon gamma.

1992 • 10 citations

ERYSIPELAS.A STATISTICAL STUDY OF FIVE HUNDRED AND SIXTY-FOUR CASES.

1907 • 9 citations

Antitumor effect of natural human tumor necrosis factor-alpha and natural human interferon-alpha in combination against human cancer transplanted into nude mice.

1989 • 8 citations

Rapid acquisition of an enhanced capacity to produce tumor necrosis factor, alpha/beta interferon, and interleukin 6 after implantation of tumor cells

1991 • 7 citations

Cyclooxygenase Inhibitors Prevent the Induction of Tolerance to the Toxic Effects of Tumor Necrosis Factor

1993 • 7 citations

Neoplasms of Bone and Related Conditions, Their Etiology, Pathogenesis, Diagnosis and Treatment

1949 • 7 citations

Immune-complex glomerulonephritis secondary to nonspecific immunotherapy

1980 • 6 citations

INJURY AS A CAUSATIVE FACTOR IN CANCER

1911 • 6 citations

THE TREATMENT OF INOPERABLE CANCER.

1908 • 6 citations

[43] Detection of endotoxin by enhancement with toxic shock syndrome toxin-1 (TSST-1)

1988 • 5 citations

THE TREATMENT OF INOPERABLE SARCOMA WITH THE MIXED TOXINS OF ERYSIPELAS AND THE BACILLUS PRODIGIOSUS.

1906 • 5 citations

Some thoughts on the problem of cancer control

1931 • 4 citations

THE TREATMENT OF INOPERABLE CANCER.

1908 • 4 citations

SYSTEMIC TREATMENT OF CANCER

1927 • 4 citations

Remarks upon the Effects Observed in the Use of Mixed Toxins (Coley) in Certain Cases of Sarcoma

1914 • 4 citations

EFFECT OF BACTERIAL TOXINS ON TUMORS

1945 • 2 citations

On the Physiological Significance of Tumor Necrosis Factor-α in the Human Amniotic Fluid

1992 • 2 citations

TREATMENT OF INOPERABLE CANCER

1920 • 2 citations

Deleted Work

1955 • 0 citations