Structure-conformation-activity studies of glucagon and semi-synthetic glucagon analogs

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

共やくエクイン・エストロゲン(Premarin)服用閉経婦人の血清エクイリン,エストロン,エストラジオール値

1980 • 725 citations

THE ESSENTIAL ROLE OF GLUCAGON IN THE PATHOGENESIS OF DIABETES MELLITUS

1975 • 574 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 473 citations

X-ray analysis of glucagon and its relationship to receptor binding

1975 • 279 citations

Combined use of proton-proton overhauser enhancements and a distance geometry algorithm for determination of polypeptide conformations. Application to micelle-bound glucagon

1981 • 267 citations

Role of glucagon in the pathogenesis of diabetes: The status of the controversy

1978 • 220 citations

Perspectives in peptide chemistry

1981 • 202 citations

Topics in Molecular Pharmacology

1984 • 141 citations

The Reaction of Glucagon with Its Receptor: Evidence for Discrete Regions of Activity and Binding in the Glucagon Molecule

1971 • 131 citations

Binding of 125I-labeled glucagon and glucagon-stimulated accumulation of adenosine 3‘:5‘-monophosphate in isolated intact rat hepatocytes. Evidence for receptor heterogeneity.

1978 • 127 citations

Structure-function relations in glucagon. Properties of highly purified Des-his1-, monoiodo-, and [Des-Asn²⁸,Thr²⁹](homoserine lactone²⁷)-glucagon

1975 • 127 citations

Formation and Structure of Gels and Fibrils from Glucagon

1969 • 121 citations

A Conformational Study of Glucagon

1968 • 107 citations

1H Nuclear-Magnetic-Resonance Studies of the Molecular Conformation of Monomeric Glucagon in Aqueous Solution

1978 • 103 citations

Conformation of glucagon. Predictions and consequences

1975 • 93 citations

The circular dichroism of glucagon solutions

1969 • 92 citations

Relative conformational rigidity in oxytocin and (1-penicillamine)-oxytocin: a proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism.

1977 • 89 citations

Relation between Conformation and Association State

1969 • 81 citations

Glucagon amino groups. Evaluation of modifications leading to antagonism and agonism.

1980 • 77 citations

Glucagon1-6 binds to the glucagon receptor and activates hepatic adenylate cyclase.

1979 • 73 citations

Conformational states of glucagon

1967 • 73 citations

Structural Studies on Polypeptide Hormones

1969 • 71 citations

Interaction of glucagon with dimyristoyl glycerophosphocholine

1977 • 62 citations

Conformational Nature of Monomeric Glucagon

1974 • 61 citations

Structural requirements for glucagon receptor binding and activation of adenylate cyclase in liver. Study of chemically modified forms of the hormone, including N alpha-trinitrophenyl glucagon, an antagonist.

1981 • 55 citations

Self-association of glucagon, Equilibrium studies

1969 • 51 citations

Evidence of association of glucagon from optical rotatory dispersion and concentration-difference spectra

1966 • 51 citations

Polypeptide Hormone Interaction

1972 • 50 citations

Molecular interactions in the model lipoprotein complex formed between glucagon and dimyristoylglycerophosphocholine

1977 • 49 citations

Effects of iodination of tyrosyl residues on the binding and action of glucagon at its receptor

1976 • 49 citations

Presence of Trimers in Glucagon Solution

1972 • 48 citations

Glucagon structure and function. II. Increased activity of iodoglucagon

1973 • 47 citations

Solid-phase synthesis of crystalline glucagon

1981 • 46 citations

Chemistry, structure and function of insulin and related hormones

1980 • 46 citations

Iodoglucagon. Preparation and Characterization

1975 • 45 citations

Polypeptide Hormone Interaction

1971 • 45 citations

Labeling of glucagon binding components in hepatocyte plasma membranes

1977 • 45 citations

Size and shape of the model lipoprotein complex formed between glucagon and dimyristoylglycerophosphocholine

1978 • 44 citations

Physicochemical characterization of glucagon-containing lipid micelles

1980 • 43 citations

Thermodynamics of the self-association of glucagon.

1977 • 42 citations

A low-resolution structural model for cubic glucagon based on packing of cylinders

1965 • 40 citations

Glucagon: Structure-Function Relationships Investigated by Sequence Deletions

1981 • 39 citations

Glucagon Conformation: Use of Opitcally Detected Magnetic Resonance and Phosphorescence of Tryptophan to Evaluate Critical Requirements for Folding of the Polypeptide Chain

1977 • 38 citations

Nα-Trinitrophenyl glucagon An inhibitor of glucagon-stimulated cyclic AMP production and its effects on glycogenolysis

1979 • 37 citations

Proton NMR studies of the association and folding of glucagon in solution

1980 • 37 citations

A reassessment of structure-function relationships in glucagon. Glucagon1-21 is a full agonist.

1978 • 36 citations

[1-Penicillamine,2-leucine]oxytocin. Synthesis and pharmacological and conformational studies of a potent peptide hormone inhibitor

1979 • 36 citations

Conformational Properties of Cyanogen Bromide-cleaved Glucagon

1972 • 34 citations

Conformational study of the potent peptide hormone antagonist [1-penicillamine,2-leucine]oxytocin in aqueous solution

1981 • 33 citations

Synthesis and characterization of a heterobifunctional photoaffinity reagent for modification of tryptophan residues and its application to the preparation of a photoreactive glucagon derivative

1980 • 32 citations

Synthesis and isolation of a glucagon antagonist

1979 • 31 citations

Synthesis of the nonacosapeptide corresponding to mammalian glucagon.

1978 • 27 citations

Effects of Hofmeister salts on the self-association of glucagon

1978 • 27 citations

Coordination complexes and catalytic properties of proteins and related substances. 98. Physical characterization of S-methylglucagon and quantitation of carbamino adduct formation

1978 • 27 citations

Zur Synthese des Glucagons, XVIII. Darstellung der Gesamtsequenz

1968 • 27 citations

Dialysis Studies. IX. On the Conformational Stability of Glucagon, Adrenocorticotropic Hormone, and Similar Peptides^*

1965 • 26 citations

Effects of Chemical and Enzymatic Modifications of Glucagon on Its Activation of Hepatic Adenyl Cyclase

1969 • 25 citations

A Study of the Conformational Properties of Glucagon in the Presence of Glycols

1974 • 24 citations

Selectively Blocked and Des-Histidine-Glucagons: Preparation and Effects on Hepatic Adenylate Cyclase Activity

1972 • 23 citations

The essential role of the imidazole group of glucagon in its biological function

1973 • 22 citations

Glucagon Structure and Function

1973 • 22 citations

Conformations of polypeptide hormones by optically detected magnetic resonance and a Zimm-Bragg analysis of helical folding in glucagon

1978 • 22 citations

The effects of the trinitrophenylation of the amino groups of glucagon on its conformational properties and on its ability to activate rat liver adenylyl cyclase

1975 • 22 citations

SYNTHESIS, PHARMACOLOGICAL, CONFORMATIONAL, AND DYNAMIC STUDIES OF THE POTENT HORMONE ANTAGONISTS [1‐PENICILLAMINE, 4‐THREONINE]‐OXYTOCIN AND [1‐PENICILLAMINE, 2‐PHENYLALANINE, 4‐THREONINE] ‐OXYTOCIN

1980 • 22 citations

Coordination complexes and catalytic properties of proteins and related substances. 87. Methylation of glucagon, characterization of the sulfonium derivative, and regeneration of the native covalent structure

1977 • 21 citations

Preparation of 2-thioltryptophan-glucagon and (tryptophan-S-glucagon)2. Differences in binding to the glucagon receptor in the hepatic adenylate cyclase system.

1980 • 21 citations

Studies with glucagon analogs

1976 • 21 citations

Semisynthetic glucagon derivatives for structure-function studies

1976 • 20 citations

(Des-Histidine1) (Nϵ-phenylthiocarbamoyllysine12)-glucagon: Effects on glycogenolysis in perfused rat liver

1980 • 20 citations

Acetylglucagon: Preparation and Characterization

1975 • 19 citations

Conformational and biological properties of a covalently linked dimer of glucagon Reaction of mono- and bifunctional sulfenyl halides

1976 • 18 citations

Conformational and Biological Properties of Partial Sequences of Glucagon

1973 • 18 citations

Thermodynamics of glucagon aggregation

1979 • 17 citations

Multiple environments of tryptophan in glucagon

1975 • 14 citations

[12-Homoarginine]glucagon: synthesis and observations on conformation, biological activity, and copper-mediated peptide cleavage

1979 • 14 citations

On the Biological and Chemical Reactivity of Carbamylated Glucagon

1972 • 13 citations

Conformation and molecular biology of polypeptide hormones II. Glucagon

1979 • 13 citations

Immunogenicity and Bioactivity of Glucagon, Modified at Methionine-27

1979 • 13 citations

Self-association of glucagon as measured by the optical properties of rhodamine 6G.

1978 • 12 citations

Carboxyl group modification in glucagon

1972 • 12 citations

Synthesis and properties of a photoaffinity probe for the glucagon receptor in hepatocyte plasma membranes

1978 • 12 citations

Reversible unfolding of glucagon by urea and temperature changes

1972 • 11 citations

Glucagon structure-function relationships using isolated rat hepatocytes

1981 • 10 citations

Preparation and properties of glucagon analogs prepared by semi-synthesis from CNBr-glucagon

1980 • 8 citations

Non-equivalence of the carboxyl groups of glucagon in the carbodiimide-promoted reaction with nucleophiles and the role of carboxyl groups in the ability of glucagon to stimulate the adenyl cyclase of rat liver

1974 • 8 citations

Properties of Amidinated Glucagons

1980 • 7 citations

Conformational changes of protected glucogon fragments bound to lysolecithin

1973 • 5 citations

The Activation of Adenylate Cyclase by Chemically Modified Forms of Glucagon and its Relationship to Receptor Binding

1980 • 4 citations

The effects of synthetic glucagon fragments on glucose-6-phosphate dehydrogenase. II.

1979 • 2 citations

Total synthesis of crystalline glucagon by the method of solid phase condensation of fragments. Protein Synthesis Group, Shanghai Institute of Biochemistry, Academia Sinica.

1975 • 1 citations