Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

1990 • 1,147 citations

Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen

1987 • 969 citations

An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter

1985 • 763 citations

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

1987 • 762 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Transcription factor AP-2 essential for cranial closure and craniofacial development

1996 • 611 citations

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.

1990 • 599 citations

Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2

1996 • 595 citations

Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.

1991 • 593 citations

Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.

1988 • 578 citations

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

1989 • 495 citations

In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development.

1991 • 479 citations

MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily.

1989 • 449 citations

Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis.

1997 • 415 citations

Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism.

1991 • 385 citations

Developmental expression of c-kit, a proto-oncogene encoded by the W locus

1990 • 349 citations

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.

1990 • 349 citations

Tumorigenicity in Human Melanoma Cell Lines Controlled by Introduction of Human Chromosome 6

1990 • 333 citations

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.

1991 • 300 citations

The Dominant W ⁴² Spotting Phenotype Results from a Missense Mutation in the c- kit Receptor Kinase

1990 • 287 citations

AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression

1997 • 285 citations

Critical factors in the biology of human cancer metastasis.

1995 • 266 citations

Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.

1989 • 260 citations

Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis.

1997 • 244 citations

Transcription factor AP2 and its role in epidermal-specific gene expression.

1991 • 234 citations

Characterization of a Dimerization Motif in AP-2 and Its Function in Heterologous DNA-Binding Proteins

1991 • 234 citations

A Human Melanoma Line Heterogeneous With Respect to Metastatic Capacity in Athymic Nude Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1984 • 231 citations

The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma.

1995 • 228 citations

Convergence of MAP kinase pathways on the ternary complex factor Sap-1a

1997 • 226 citations

Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene

1996 • 217 citations

Deletion of the c-kit protooncogene in the human developmental defect piebald trait.

1991 • 212 citations

Progression of human cutaneous melanoma is associated with loss of expression of c‐kit proto‐oncogene receptor

1992 • 209 citations

An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene.

1989 • 170 citations

Epidemiology of pre‐invasive and invasive malignant melanoma in Western Australia

1980 • 167 citations

The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells.

1995 • 157 citations

Loss of AP-2 Results in Up-regulation ofMCAM/MUC18 and an Increase in Tumor Growth and Metastasis of Human Melanoma Cells

1998 • 155 citations

Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential.

1996 • 149 citations

Loss of c-kit expression in cultured melanoma cells.

1992 • 148 citations

Ultraviolet B irradiation promotes tumorigenic and metastatic properties in primary cutaneous melanoma via induction of interleukin 8.

1995 • 144 citations

Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity.

1994 • 139 citations

Correlation of Growth Capacity of Human Tumor Cells in Hard Agarose With Their In Vivo Proliferative Capacity at Specific Metastatic Sites

1989 • 135 citations

An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2.

1993 • 124 citations

Direct correlation between MUC18 expression and metastatic potential of human melanoma cells

1993 • 124 citations

Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element.

1985 • 122 citations

Dominant-negative CREB inhibits tumor growth and metastasis of human melanoma cells

1997 • 121 citations

Identification of a recurring translocation site involving chromosome 6 in human malignant melanoma.

1989 • 106 citations

Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response.

1992 • 105 citations

KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells.

1993 • 104 citations

Loss of heterozygosity in sporadic primary cutaneous melanoma

1995 • 102 citations

Transcription Factor AP-2 Regulates Human Insulin-like Growth Factor Binding Protein-5 Gene Expression

1995 • 101 citations

Bcl-2 expression in human melanocytes and melanocytic tumors.

1994 • 98 citations

Techniques of cutaneous examination for the detection of skin cancer

1995 • 97 citations

N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation.

1994 • 93 citations

Involvement of chromosome 6 in rearrangements in human malignant melanoma cell lines

1983 • 84 citations

Bcl-2 expression in malignant melanoma and its prognostic significance

1996 • 84 citations

Characterization of the Promoter Region of the Human c‐kit Proto‐oncogene

1993 • 81 citations

Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53.

1994 • 79 citations

Molecular mechanisms of melanoma metastasis

1997 • 78 citations

Mutations and defective expression of the WAF1 p21 tumour-suppressor gene in malignant melanomas

1995 • 77 citations

Human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene.

1992 • 74 citations

Interaction of cellular proteins with the human T-cell leukemia virus type I transcriptional control region. Purification of cellular proteins that bind the 21-base pair repeat elements.

1990 • 67 citations

The genomic structure of the human AP-2 transcription factor

1994 • 59 citations

Abnormalities in the CDKN2 (p16INK4/MTS-1) gene in human melanoma cells: relevance to tumor growth and metastasis.

1995 • 46 citations

Localization of the gene for the DNA-binding protein AP-2 to human chromosome 6p22.3-pter

1991 • 44 citations

CADHERIN EXPRESSION IN MELANOCYTIC NAEVI AND MALIGNANT MELANOMAS

1996 • 43 citations

Effect of ultraviolet-B radiation on the in vivo growth of murine melanoma cells.

1988 • 41 citations

An AP-2 Element Acts Synergistically with the Cyclic AMP- and Phorbol Ester-Inducible Enhancer of the Human Proenkephalin Gene

1989 • 41 citations

Linkage analysis in familial melanoma kindreds to markers on chromosome 6p

1994 • 36 citations

Wavelength-specific induction of immediate early genes by ultraviolet radiation

1996 • 32 citations

Expression of gp 185^HER‐2 in human cutaneous melanoma: Implications for experimental immunotherapeutics

1994 • 31 citations

Wild-Type p53 Regulates Its Own Transcription in a Cell-Type Specific Manner

1995 • 30 citations

Intertumoral heterogeneity of receptor-tyrosine kinases expression in human melanoma cell lines with different metastatic capabilities.

1994 • 29 citations

An Alternatively Spliced mRNA from the AP-2 Gene Encodes a Negative Regulator of Transcriptional Activation by AP-2

1993 • 28 citations

The Biology of Melanoma Metastasis

1988 • 24 citations

Microdissection based cloning of a translocation breakpoint in a human malignant melanoma.

1995 • 15 citations

The putative melanoma tumor-suppressor gene on human chromosome 6q

1992 • 13 citations

Transcription Factor AP-2 Regulates Human Insulin-like Growth Factor Binding Protein-5 Gene Expression

1995 • 13 citations

Identification of a 10-base pair protein binding site in the promoter of the hamster H3.2 gene required for the S phase dependent increase in transcription and its interaction with a Jun-like nuclear factor.

1992 • 12 citations

Characterization of the promoter region of the human c-kit proto-oncogene

1994 • 6 citations