Initial characterization of the major mouse cytochrome p450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-Amino-1,2,4-Benzotriazine-1,4-di-N-Oxide (Tirapazamine, SR 4233, Win 59075)

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

1953 • 4,357 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

[56] DT diaphorase

1967 • 521 citations

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues.

1990 • 487 citations

The 3-Methyl-2-benzothiazolone Hydrazone Test. Sensitive New Methods for the Detection, Rapid Estimation, and Determination of Aliphatic Aldehydes

1961 • 426 citations

SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells

1986 • 391 citations

Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture.

1984 • 363 citations

[30] DT-diaphorase: Purification, properties, and function

1990 • 316 citations

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily.

1989 • 303 citations

Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

1985 • 301 citations

DT-diaphorase and cancer chemotherapy

1992 • 284 citations

Cytosolic NAD(P)H:(Quinone‐acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol

1990 • 261 citations

Oxidative stress in chemical toxicity

1987 • 244 citations

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

1990 • 218 citations

Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450.

1982 • 170 citations

Molecular mechanisms for the hypoxiadependent activation of 3-amino-1,2,4-benzotriazine-1, 4-dioxide (SR 4233)

1988 • 152 citations

Role of ethanol-inducible cytochrome P450 (P450IIE1) in catalysing the free radical activation of aliphatic alcohols

1991 • 146 citations

Regulation and expression of four cytochrome P-450 isoenzymes, NADPH-cytochrome P-450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneoplastic and neoplastic lesions in rat liver

1985 • 135 citations

Monoclonal antibodies to ethanol-induced rat liver cytochrome P-450 that metabolizes aniline and nitrosamines.

1987 • 126 citations

Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity.

1988 • 121 citations

Selective Activation of Drugs by Redox Processes

1990 • 111 citations

Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors

1990 • 109 citations

Monoclonal antibodies to phenobarbital-induced rat liver cytochrome P-450

1984 • 108 citations

Molecular basis for a functionally unique cytochrome P450IIB1 variant.

1991 • 93 citations

Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue

1990 • 92 citations

Microsomal reduction of 3-amino-1,2,4-benzotriazine 1,4-dioxide to a free radical.

1991 • 88 citations

Mechanisms of the Inhibition of Cytochrome P 450-Mediated Drug Oxidation by Therapeutic Agents

1987 • 85 citations

Nitroimidazole bioreductive metabolism

1987 • 83 citations

An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin.

1988 • 81 citations

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-l,2,4-benzotriazine-l ,4-dioxide (SR 4233, WIN 59075) by mouse liver

1992 • 78 citations

Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy

1988 • 76 citations

Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins

1989 • 70 citations

Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes.

1986 • 70 citations

Keynote address: Bioreductive mechanisms

1992 • 69 citations

Enzymology of the reductive bioactivation of SR 4233

1990 • 69 citations

Monoclonal antibody-directed characterization of benzene, ethoxyresorufin and pentoxyresorufin metabolism in rat liver microsomes

1990 • 66 citations

Structure-activity relationships for benzotriazine DI-N-oxides

1989 • 64 citations

Regulation of the expression of the sex‐specific isoforms of cytochrome P‐450 in rat liver

1991 • 61 citations

SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures

1991 • 61 citations

Enzyme-Directed Bioreductive Drug Development

1990 • 58 citations

Monoclonal antibodies inhibitory to rat hepatic cytochromes P-450: P-450 form specificities and use as probes for cytochrome P-450-dependent steroid hydroxylations.

1987 • 56 citations

Enzymology of the reduction of the potent benzotriazine-di-n-oxide hypoxic cell cytotoxin SR 4233 (win 59075) by NAD(P)H: (Quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from walker 256 rat tumour cells

1992 • 50 citations

N-alkylaminobenzotriazoles as isozyme-selective suicide inhibitors of rabbit pulmonary microsomal cytochrome P-450.

1986 • 41 citations

Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples

1991 • 40 citations

Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines

1990 • 38 citations

Purification and properties of a metyrapone-reducing enzyme from mouse liver microsomes—this ketone is reduced by an aldehyde reductase

1989 • 38 citations

Selective Extraction of DT Diaphorase from Mitochondria and Microsomes.

1960 • 36 citations

Cytochrome P-450, Reductive Metabolism, And Cell Injury

1989 • 35 citations

Monoclonal antibodies to rat liver cytochrome P-450 2c/RLM5 that regiospecifically inhibit steroid metabolism

1989 • 34 citations

Altered Regulation of the Cytochrome P4501A1 Gene: Novel Inducer-Independent Gene Expression in Pulmonary Carcinoma Cell Lines

1989 • 34 citations

In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agent.

1989 • 34 citations

Immunochemical detection of human liver cytochrome P450 forms related to phenobarbital-inducible forms in the mouse

1990 • 34 citations

A Constitutive Member of the Rat Cytochrome P450IIB Subfamily: Full-Length Coding Sequence of the P450IIB3 cDNA

1988 • 34 citations

One-electron reductive bioactivation of 2,3,5,6-tetramethylbenzoquinone by cytochrome P450

1992 • 29 citations

Comparative studies on coumarin and testosterone metabolism in mouse and human livers

1991 • 26 citations

Carbonyl reduction of metyrapone in human liver

1991 • 21 citations

High-performance liquid chromatographic assay for the benzotriazine di-N-oxide (SR 4233) and its reduced metabolites in biological materials

1988 • 15 citations

Induction of rat liver microsomal and nuclear cytochrome p-450 by dietary 2-acetylaminofluorene and butylated hydroxytoluene

1989 • 11 citations

The characteristics of the microsomal hydroxylation of tolbutamide

1991 • 8 citations

Aminopyrine-N-demethylase I. Directed modification of substrates’ structure as a way of production of inducer of the monooxygenase isoform P-450b

1991 • 6 citations

Differences between induction effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and phenobarbitone

1989 • 6 citations

Covalent Binding to Proteins as a Mechanism of Chemical Toxicity

1984 • 6 citations

Aminopyrine-N-demethylase. II. Characterization of a unique monooxygenase isoform P-450ap

1991 • 1 citations