Regulation of the expression of the sex‐specific isoforms of cytochrome P‐450 in rat liver

Growth Hormone-Releasing Factor from a Human Pancreatic Tumor That Caused Acromegaly

1982 • 1,263 citations

Sexual Dimorphism in the Control of Growth Hormone Secretion*

1985 • 749 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

1985 • 593 citations

Age- and Sex-Related Differences in Episodic Growth Hormone Secretion in the Rat*

1979 • 543 citations

Interactions of hepatic cytochromes P-450 with steroid hormones

1988 • 441 citations

Sex-Related Differences in Drug Metabolism

1975 • 408 citations

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

1988 • 377 citations

Species, strain and sex differences in metabolism of hexobarbitone, amidopyrine, antipyrine and aniline

1958 • 372 citations

N-hydroxy-2-acetylaminofluorene sulfotransferase: its probable role in carcinogenesis and in protein-(methion-S-yl) binding in rat liver.

1970 • 354 citations

Dose-response characteristics of aflatoxin B1 carcinogenesis in the rat.

1967 • 352 citations

Sex Steroid Induced Changes in Hepatic Enzymes

1983 • 314 citations

Characterization of three highly purified cytochromes P-450 from hepatic microsomes of adult male rats.

1984 • 301 citations

Rat hepatic cytochrome P-450 isoenzyme 2c. Identification as a male-specific, developmentally induced steroid 16 alpha-hydroxylase and comparison to a female-specific cytochrome P-450 isoenzyme.

1984 • 268 citations

Sex difference of cytochrome P-450 in the rat: Purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats

1983 • 233 citations

Neonatal Imprinting of Liver Microsomal Hydroxylation and Reduction of Steroids

1973 • 229 citations

Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone.

1987 • 177 citations

Inhibition of Growth Hormone Secretion in the Rat by Synthetic Somatostatin

1974 • 165 citations

Purification and characterization of two constitutive forms of rat liver microsomal cytochrome P-450.

1982 • 156 citations

Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases.

1989 • 154 citations

Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases.

1985 • 148 citations

Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression.

1988 • 138 citations

Characteristics of nitro reduction of the carcinogenic agent, 4-nitroquinolone N-oxide

1970 • 134 citations

Cytochrome P450 in livers of diabetic rats: Regulation by growth hormone and insulin

1989 • 113 citations

Age- and sex-related expression of cytochromes P450f and P450g in rat liver

1986 • 110 citations

Species and sex differences in electron transport systems in liver microsomes and their relationship to ethylmorphine demethylation

1969 • 108 citations

Purification, characterization, and pituitary regulation of the sex-specific cytochrome P-450 15 beta-hydroxylase from liver microsomes of untreated female rats.

1984 • 105 citations

Effect of Growth Hormone and Ectopic Transplantation of Pituitary Gland on Sex-Specific Forms of Cytochrome P-450 and Testosterone and Drug Oxidations in Rat Liver1

1986 • 101 citations

Studies on the regulation of the activity of drug oxidation in rat liver microsomes by androgen and estrogen

1970 • 98 citations

Female-Predominant Rat Hepatic P-450 Forms j (IIE1) and 3 (IIA1) Are under Hormonal Regulatory Controls Distinct from Those of the Sex-Specific P-450 Forms*

1989 • 97 citations

Sex change in cytochrome P-450 phenotype by growth hormone treatment of adult rat hepatocytes maintained in a culture system on matrigel.

1988 • 95 citations

Sex difference in the O-dealkylation activity of 7-hydroxycoumarin O-alkyl derivatives in liver microsomes of rats

1980 • 92 citations

Mechanisms of Chemical Carcinogenesis

1978 • 91 citations

Cytochrome P-450s: polymorphic multigene families involved in carcinogen activation

1986 • 87 citations

Purification and characterization of a new form (RLM2) of liver microsomal cytochrome P-450 from untreated rat.

1985 • 85 citations

N-hydroxylation of carcinogenic and mutagenic aromatic amines.

1983 • 81 citations

Prenatal Exposure to Phenobarbital Permanently Decreases Testosterone and Causes Reproductive Dysfunction

1982 • 75 citations

Responses to insulin by two forms of rat hepatic microsomal cytochrome P-450 that undergo major (RLM6) and minor (RLM5b) elevations in diabetes.

1987 • 74 citations

Sexual differentiation of cytochrome P-450 in rat liver. Evidence for a constitutive isozyme as the male-specific 16 alpha-hydroxylase.

1985 • 74 citations

Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N,O-sulfonation in chemical carcinogenesis of aromatic amines.

1983 • 71 citations

Regulation and substrate specificity of a steroid sulfate-specific hydroxylase system in female rat liver microsomes.

1975 • 67 citations

A dual role of growth hormone as a feminizing and masculinizing factor in the control of sex-specific cytochrome P-450 isozymes in rat liver

1989 • 60 citations

Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes.

1988 • 60 citations

Effects of Hypophysectomy and Growth Hormone Treatment on Sex-Specific Forms of Cytochrome P-450 in Relation to Drug and Steroid Metabolisms in Rat Liver Microsomes

1986 • 59 citations

Similarities and differences in the regulation of hepatic cytochrome p-450 enzymes by diabetes and fasting in male rats

1989 • 56 citations

Monoclonal antibodies inhibitory to rat hepatic cytochromes P-450: P-450 form specificities and use as probes for cytochrome P-450-dependent steroid hydroxylations.

1987 • 56 citations

Hormonal Regulation of Male-specific Rat Hepatic Cytochrome P-450g (P-450IIC13) by Androgens and the Pituitary

1989 • 55 citations

Sodium-dependent efflux of K+ and Rb+ through the activated sodium channel of neuroblastoma cells

1976 • 55 citations

Partial purification and characterization of cytochrome P-450 responsible for the occurrence of sex difference in drug metabolism in the rat

1981 • 53 citations

Rat hepatic cytochrome P-450 isozyme specificity for the metabolism of the steroid sulfate, 5α-androstane-3α,17β-diol-3,17-disulfate

1984 • 52 citations

Neonatal imprinting and the turnover of microsomal cytochrome P-450 in rat liver.

1975 • 47 citations

Purification and Characterization of Three Male-Specific and One Female-Specific Forms of Cytochrome P-450 from Rat Liver Microsomes1

1986 • 46 citations

cDNA cloning, sequence, and regulation of a major female-specific and growth hormone-inducible rat liver cytochrome P-450 active in 15 beta-hydroxylation of steroid sulfates.

1988 • 45 citations

Suppression in the expression of a male-specific cytochrome P450, P450-male: Difference in the effect of chemical inducers on P450-male mRNA and protein in rat livers

1989 • 45 citations

Role of neonatal androgen in the development of hepatic microsomal drug-metabolizing enzymes.

1975 • 43 citations

STUDIES ON MECHANISM OF SEX DIFFERENCE IN DRUG-OXIDIZING ACTIVITY OF LIVER MICROSOMES

1968 • 40 citations

Sexual Differences in Hepatic Sulphurylation of Deoxycorticosterone in Rats

1973 • 38 citations

The effects of gonadectomy and hypophysectomy on the metabolism of imipramine and lidocaine by the liver of male and female rats

1980 • 34 citations

Characteristics of neonatal androgen-induced imprinting of rat hepatic microsomal monooxygenases

1977 • 33 citations

Feminization of Hepatic Steroid Metabolism in Male Rats Following Electrothermic Lesion of the Hypothalamus

1976 • 32 citations

Possible Role of Somatostatin in the Regulation of the Sexually Differentiated Steroid Metabolism and Prolactin Receptor in Rat Liver*

1983 • 31 citations

Neonatal imprinting and hepatic cytochrome P-450. I. Comparison of testosterone hydroxylation in a reconstituted system between neonatally imprinted and nonimprinted rats.

1980 • 31 citations

Xenobiotic imprinting of the hepatic monooxygenase system

1985 • 28 citations

Exposure of Newborn Rats to Pharmacologically Active Compounds May Permanently Alter Carcinogen Metabolism

1981 • 28 citations

On mechanisms of sex differences in chemical carcinogenesis: effects of implantation of ectopic pituitary grafts on the early stages of liver carcinogenesis in the rat

1984 • 27 citations

Characterization of a cDNA for rat P-450g, a highly polymorphic, male-specific cytochrome in the P-450IIC subfamily

1989 • 27 citations

Isolation and Comparison of Four Cytochrome P-450 Enzymes from Phenobarbital-Induced Rat Liver: Three Forms Possessing Identical NH<sub>2</sub>-Terminal Sequences

1985 • 27 citations

The N-hydroxy metabolites of N-methyl-4-aminoazobenzene and related dyes as proximate carcinogens in the rat and mouse.

1979 • 26 citations

Pituitary regulation of cytochrome P-450-mediated metabolism of steroids and xenobiotics in rat liver microsomes

1986 • 26 citations

The hypothalamic–hypophyseal–gonadal regulation of hepatic glutathione S-transferases in the rat

1981 • 26 citations

Further studies on the persistence of neonatal androgen imprinting on sex-specific cytochrome P-450, testosterone and drug oxidations.

1987 • 26 citations

Neonatal phenobarbital administration results in increased cytochrome P450-dependent monooxygenase activity in adult male and female rats

1983 • 25 citations

Central Control of Hepatic Steroid Metabolism: Effect of Discrete Hypothalamic Lesions*

1978 • 23 citations

The effects on hepatic steroid metabolism of an ectopic pituitary graft: A time study

1977 • 22 citations

Neonatal Testosterone Imprinting of Hepatic Microsomal Drug Metabolism and a Male-Specific Form of Cytochrome P-450 in the Rat1

1984 • 22 citations

Neoplasms in rats with 2-acetaminofluorene and sex hormones.

1947 • 22 citations

Sex-dependent effect of streptozotocin-induced diabetes mellitus on hepatic steroid metabolism in the rat

1986 • 21 citations

Organ specificity of the sex dependent regulation of aryl hydrocarbon hydroxylase (AHH) in rat

1976 • 21 citations

Long-term effects of neonatal phenobarbital exposure on aflatoxin b1 disposition in adult rats.

1983 • 19 citations

Neonatal imprinting and hepatic cytochrome P-450. Immunochemical evidence for the presence of a sex-dependent and neonatally imprinted form(s) of hepatic cytochrome P-450.

1982 • 15 citations

Is steroid-16α-hydroxylase supported by more than one monooxygenase?

1978 • 15 citations

Characterization of particle-associated choriomammotrophin and progesterone in ovine placentomes

1986 • 15 citations

Effect of Sex and Castration on Hepatic and Intestinal Activity of Drug-Metabolizing Enzymes

1974 • 14 citations

Effects of neonatal and adult castration on the in vitro metabolism of steroids and xenobiotics in rat liver.

1986 • 12 citations

A single neonatal treatment with methylcholanthrene or benzo(a)pyrene alters microsomal enzyme activity for life.

1987 • 11 citations

Neonatal phenobarbital imprinting of hepatic microsomal enzymes in adult rats: Modulation by neonatal testosterone presence

1985 • 11 citations

Effects of somatostatin and testosterone on the hepatic monooxygenase system in castrated male rats.

1985 • 7 citations

Xenobiotic imprinting of hepatic metabolic enzyme systems: effect of neonatal 3-methylcholanthrene administration

1985 • 6 citations