Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

2002 • 1,644 citations

A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

2007 • 1,359 citations

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells

2007 • 1,161 citations

Antigen-Specific T Cell Sensitization Is Impaired in IL-17-Deficient Mice, Causing Suppression of Allergic Cellular and Humoral Responses

2002 • 1,063 citations

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

2007 • 804 citations

Mast cells are essential intermediaries in regulatory T-cell tolerance

2006 • 742 citations

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

2008 • 725 citations

Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β

2007 • 704 citations

Th17 Cell Differentiation: The Long and Winding Road

2008 • 675 citations

Mast Cells Are Essential for Early Onset and Severe Disease in a Murine Model of Multiple Sclerosis

2000 • 427 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

OX40 costimulation turns off Foxp3+ Tregs

2007 • 398 citations

Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF

2006 • 390 citations

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

2008 • 383 citations

CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction

2008 • 377 citations

Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40

2004 • 320 citations

Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

2004 • 305 citations

Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis

1999 • 250 citations

Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells

2004 • 226 citations

Genetic Inversion in Mast Cell-Deficient Wsh Mice Interrupts Corin and Manifests as Hematopoietic and Cardiac Aberrancy

2008 • 207 citations

Regulatory T Cell Suppression and Anergy Are Differentially Regulated by Proinflammatory Cytokines Produced by TLR-Activated Dendritic Cells

2004 • 202 citations

The Master Switch: The Role of Mast Cells in Autoimmunity and Tolerance

2008 • 198 citations

Mast cell–derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice

2007 • 190 citations

Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease

2008 • 163 citations

Mast cell–derived TNF can promote Th17 cell–dependent neutrophil recruitment in ovalbumin-challenged OTII mice

2006 • 157 citations

Involvement of both ‘allergic’ and ‘autoimmune’ mechanisms in EAE, MS and other autoimmune diseases

2003 • 128 citations

Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination

2003 • 128 citations

Mast Cells Exert Effects Outside the Central Nervous System to Influence Experimental Allergic Encephalomyelitis Disease Course

2003 • 126 citations

Cutting Edge: CD4 T Cell-Mast Cell Interactions Alter IgE Receptor Expression and Signaling

2008 • 85 citations

Selective Activation of Fyn/PI3K and p38 MAPK Regulates IL-4 Production in BMMC under Nontoxic Stress Condition

2007 • 78 citations

A Key Regulatory Role for Histamine in Experimental Autoimmune Encephalomyelitis: Disease Exacerbation in Histidine Decarboxylase-Deficient Mice

2006 • 76 citations

CD134 plays a crucial role in the pathogenesis of EAE and is upregulated in the CNS of patients with multiple sclerosis

2003 • 64 citations

Bone Marrow-Derived Dendritic Cells Reverse the Anergic State of CD4+CD25+ T Cells without Reversing Their Suppressive Function

2005 • 57 citations