A novel functional polymorphism in the uridine diphosphate–glucuronosyltransferase 2B7 promoter with significant impact on promoter activity

The LightCycler ^TM : A Microvolume Multisample Fluorimeter with Rapid Temperature Control

1997 • 908 citations

Human UGT2B7 catalyzes morphine glucuronidation.

1997 • 416 citations

UDP-Glucuronosyltransferases

2000 • 415 citations

Morphine-6-glucuronide, a potent mu agonist

1987 • 365 citations

The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268).

1998 • 320 citations

The analgesic activity of morphine‐6‐glucuronide.

1992 • 272 citations

Polymorphic Gene Regulation and Interindividual Variation of UDP-glucuronosyltransferase Activity in Human Small Intestine

2000 • 247 citations

Morphine metabolism in man

1974 • 228 citations

Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.

1993 • 222 citations

Incomplete cross tolerance and multiple mu opioid peptide receptors

2001 • 208 citations

The pharmacokinetics of morphine and morphine glucuronides in kidney failure

1993 • 202 citations

Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide

1991 • 178 citations

A pharmacogenetic study of uridine diphosphate–glucuronosyltransferase 2B7 in patients receiving morphine

2003 • 174 citations

Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene

2000 • 170 citations

3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7).

2000 • 167 citations

Systematic review of factors affecting the ratios of morphine and its major metabolites

1998 • 167 citations

Oral morphine in cancer pain: influences on morphine and metabolite concentration

1990 • 163 citations

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

2003 • 160 citations

Expression of UDP-Glucuronosyltransferases (UGTs) 2B7 and 1A6 in the Human Brain and Identification of 5-Hydroxytryptamine as a Substrate

1999 • 159 citations

Relationships Among Morphine Metabolism, Pain and Side Effects During Long-Term Treatment

2003 • 141 citations

Isolation and Identification of Morphine 3- and 6-Glucuronides, Morphine 3,6-Diglucuronide, Morphine 3-Ethereal Sulfate, Normorphine, and Normorphine 6-Glucuronide as Morphine Metabolites in Humans

1977 • 136 citations

Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7.

2001 • 133 citations

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

2002 • 132 citations

Human brain metabolism of morphine and naloxone

1988 • 93 citations

Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy

2003 • 89 citations

Start of oral morphine to cancer patients: effective serum morphine concentrations and contribution from morphine-6-glucuronide to the analgesia produced by morphine

2000 • 87 citations

Human UDP-Glucuronosyltransferase 2B7

2001 • 81 citations

Octamer transcription factor-1 enhances hepatic nuclear factor-1alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter.

2000 • 73 citations

EXTRAHEPATIC MORPHINE METABOLISM IN MAN DURING THE ANHEPATIC PHASE OF ORTHOTOPIC LIVER TRANSPLANTATION

1989 • 51 citations

Glucuronidation of Morphine in Human Kidney Microsomes

1988 • 48 citations

Hepatocyte Nuclear Factor-1α Is a Causal Factor Responsible for Interindividual Differences in the Expression of UDP-Glucuronosyltransferase 2B7 mRNA in Human Livers

2002 • 44 citations

Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7

2001 • 37 citations

Presystemic glucuronidation of morphine in humans and rhesus monkeys: subcellular distribution of the UDP-glucuronyltransferase in the liver and intestine

1986 • 32 citations

Variability in Zidovudine Serum Concentrations

1996 • 17 citations

Pharmacokinetics and Pharmacodynamics of High‐Dose Zidovudine Administered as a Continuous Infusion in Patients With Cancer

1995 • 12 citations