Endothelin-1-Induced Reductions in Cerebral Blood Flow: Dose Dependency, Time Course, and Neuropathological Consequences

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem

1986 • 4,155 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion

1981 • 1,420 citations

Thresholds of focal cerebral ischemia in awake monkeys

1981 • 1,144 citations

Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor

1992 • 880 citations

Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion.

1989 • 516 citations

Calcitonin gene-related peptide: functional role in cerebrovascular regulation.

1986 • 500 citations

Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells.

1990 • 480 citations

Greenfield's Neuropathology

1993 • 445 citations

Cerebral arterial spasm

1974 • 390 citations

Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia.

1989 • 349 citations

The Influence of Sympathetic Nervous Activity on Cerebral Blood Flow

1972 • 306 citations

Focal Cerebral Ischaemia in the Rat: 2. Regional Cerebral Blood Flow Determined by [¹⁴C]Iodoantipyrine Autoradiography following Middle Cerebral Artery Occlusion

1981 • 306 citations

Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia.

1987 • 302 citations

Autoradiographic distribution in rat tissues of binding sites for endothelin: a neuropeptide?

1989 • 299 citations

The importance of avoiding ?dark? neurons in experimental neuropathology

1961 • 259 citations

Expression of the potent vasoconstrictor endothelin in the human central nervous system.

1990 • 228 citations

H2 clearance measurement of blood flow: a review of technique and polarographic principles.

1980 • 213 citations

Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia

1990 • 207 citations

Endothelin and the production of cerebral vasospasm in dogs

1989 • 188 citations

Cl-dependent K transport in a pure population of volume-regulating human erythrocytes

1989 • 187 citations

Neuropeptide Y: Immunocytochemical localization to and effect upon feline pial arteries and veins in vitro and in situ

1984 • 159 citations

Nimodipine and the Haemodynamic and Histopathological Consequences of Middle Cerebral Artery Occlusion in the Rat

1986 • 147 citations

Correlation between rCBF and histological changes following temporary middle cerebral artery occlusion.

1980 • 144 citations

Cerebral microvessel endothelium is producing endothelin

1990 • 143 citations

The concepts of thresholds of ischaemia in relation to brain structure and function.

1977 • 142 citations

Increased endothelin concentration in CSF from patients with subarachnoid hemorrhage

2009 • 142 citations

Endothelin acts in feline and canine cerebral arteries from the adventitial side.

1989 • 138 citations

Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat

1992 • 121 citations

Cerebral Blood Flow: Physiologic and clinical Aspects

1988 • 117 citations

Reduction of local cerebral blood flow to pathological levels by endothelin-1 applied to the middle cerebral artery in the rat

1990 • 115 citations

A vasoactive peptide, endothelin-3, is produced by and specifically binds to primary astrocytes

1991 • 115 citations

Cerebrovascular Diseases

1988 • 114 citations

Cerebrospinal fluid endothelin-1 and endothelin-3 levels in normal and neurosurgical patients: A clinical study and literature review

1991 • 105 citations

Experimental Study on the Genesis of Cerebral Vasospasm

1975 • 104 citations

Endothelin-1 of canine basilar artery in vasospasm

1992 • 97 citations

Effects of endothelin on regional blood flows in squirrel monkeys.

1989 • 95 citations

[125I]Endothelin-l Binding Sites

1989 • 92 citations

CORRELATION OF TRIPHENYLTETRAZOLIUM CHLORIDE PERFUSION STAINING WITH CONVENTIONAL NEUROHISTOLOGY IN THE DETECTION OF EARLY BRAIN ISCHAEMIA

1988 • 90 citations

Ischemia and reperfusion increase 125I-labeled endothelin-1 binding in rat cardiac membranes

1990 • 86 citations

A dynamic concept of middle cerebral artery occlusion and cerebral infarction in the acute state based on interpreting severe hyperemia as a sign of embolic migration.

1984 • 71 citations

Contractile Responses to Endothelin in Feline Cortical Vessels in situ

1990 • 69 citations

Effects of endothelin on blood vessels of the brain and choroid plexus

1990 • 63 citations

Effect of endothelin on cortical microvascular perfusion in rats.

1990 • 62 citations

Mechanisms of Action of Endothelin on Isolated Feline Cerebral Arteries: In vitro Pharmacology and Electrophysiology

1989 • 59 citations

Animal Models for the Study of Drugs in Ischemic Stroke

1989 • 58 citations

Enhanced vasoconstrictor effect of endothelin in cerebral arteries from rats with subarachnoid haemorrhage

1990 • 57 citations

Role of endothelium and calcium channels in endothelin‐induced contraction of human cerebral arteries

1990 • 52 citations

Increased endothelin‐like immunoreactivity in ibotenic acid‐lesioned hippocampal formation of the rat brain

1989 • 51 citations

Effects of intracisternal endothelin-1 injection on blood flow to the lower brain stem

1991 • 40 citations

Binding sites for125I ET-1, ET-2, ET-3 and vasoactive intestinal contractor are present in adult rat brain and neurone-enriched primary cultures of embryonic brain cells

1991 • 36 citations

Experimental studies of ischemic brain edema. Effect of recirculation of the blood flow after ischemia on post-ischemic brain edema.

1989 • 11 citations

Deleted Work

1955 • 0 citations