2′,5′-Oligoadenylate-Antisense Chimeras Cause RNase L to Selectively Degrade bcr/abl mRNA in Chronic Myelogenous Leukemia Cells

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia

1994 • 514 citations

Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action

1993 • 509 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 495 citations

BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death [published erratum appears in Blood 1994 Jun 15;83(12):3835]

1994 • 378 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

Selective Inhibition of Leukemia Cell Proliferation by BCR-ABL Antisense Oligodeoxynucleotides

1991 • 353 citations

Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

1985 • 266 citations

In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides.

1992 • 223 citations

Blockage of NF-κB Signaling by Selective Ablation of an mRNA target by 2-5A Antisense Chimeras

1994 • 217 citations

Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.

1994 • 176 citations

Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase.

1994 • 156 citations

Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line

1993 • 141 citations

Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera.

1993 • 109 citations

Acute- and chronic-phase chronic myelogenous leukemia colony-forming units are highly sensitive to the growth inhibitory effects of c-myb antisense oligodeoxynucleotides

1992 • 97 citations

Antisense oligonucleotides as therapeutics for malignant diseases.

1997 • 91 citations

2-5A-Dependent RNase L

1997 • 85 citations

Acute- and chronic-phase chronic myelogenous leukemia colony-forming units are highly sensitive to the growth inhibitory effects of c-myb antisense oligodeoxynucleotides

1992 • 83 citations

Targeting RNA decay with 2′,5′ oligoadenylate-antisense in respiratory syncytial virus-infected cells

1997 • 71 citations

BCR-ABL Antisense Oligodeoxynucleotide In Vitro Purging and Autologous Bone Marrow Transplantation for Patients With Chronic Myelogenous Leukemia in Advanced Phase

1998 • 69 citations

BCR-ABL antisense oligodeoxyribonucleotides suppress the growth of leukemic and normal hematopoietic cells by a sequence-specific but nonantisense mechanism [see comments]

1995 • 62 citations

Treatment of Philadelphia1 Leukemia in Severe Combined Immunodeficient Mice by Combination of Cyclophosphamide and bcr/abl Antisense Oligodeoxynucleotides

1997 • 57 citations

Retrovirally transduced antisense sequences stably suppress P210BCR-ABL expression and inhibit the proliferation of BCR/ABL-containing cell lines

1993 • 56 citations

Liposomal delivery of methylphosphonate antisense oligodeoxynucleotides in chronic myelogenous leukemia [see comments]

1994 • 56 citations

Leukemia treatment in severe combined immunodeficiency mice by antisense oligodeoxynucleotides targeting cooperating oncogenes.

1995 • 46 citations

Catalytic Cleavage of an RNA Target by 2–5A Antisense and RNase L

1995 • 44 citations

Inhibition of Protein-Tyrosine Kinase Activity in Intact Cells by the Aptameric Action of Oligodeoxynucleotides

1995 • 40 citations

2',5'-Oligoadenylate:antisense chimeras. Synthesis and properties

1993 • 38 citations

(2′‐5′)オリゴアデニル酸‐アンチセンスキメラでの分解のため標的RNA

1993 • 31 citations

Development of 2',5'-Oligonucleotides as Therapeutic Agents

1994 • 27 citations

Synthesis and Characterization of Composite Nucleic Acids Containing 2‵,5‵-Oligoriboadenylate Linked to Antisense DNA

1996 • 23 citations

Synthesis of a 5′-thiophosphate analogue of 2-5A, a phosphatase resistant activator of the 2-5A-dependent ribonuclease

1994 • 23 citations

Synthesis and Properties of Second-Generation 2-5A-Antisense Chimeras with Enhanced Resistance to Exonucleases

1997 • 18 citations

Nuclease-Resistant Composite 2‘,5‘-Oligoadenylate−3‘,5‘-Oligonucleotides for the Targeted Destruction of RNA: 2−5A-Iso-antisense

1998 • 17 citations

Inhibition of P210BCR/ABL Expression in K562 Cells by Electroporation with an Antisense Oligonucleotide

1990 • 17 citations

Deleted Work

1955 • 0 citations