Fibroblast growth factor overexpressing breast carcinoma cells as models of angiogenesis and metastasis

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Angiogenesis.

1992 • 2,581 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Structural and Functional Diversity in the FGf Receptor Multigene Family

1992 • 1,262 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

1985 • 1,155 citations

A potent specific pure antiestrogen with clinical potential.

1991 • 1,111 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 • 822 citations

A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines.

1986 • 641 citations

Tumor interactions with the vasculature: angiogenesis and tumor metastasis

1990 • 598 citations

Microvessel quantitation and prognosis in invasive breast carcinoma

1992 • 566 citations

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

1991 • 523 citations

Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma.

1994 • 473 citations

Complexity of FGF receptors: genetic basis for structural diversity and functional specificity

1992 • 441 citations

Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.

1992 • 404 citations

Molecular Cloning of a Novel Cytokine cDNA Encoding the Ninth Member of the Fibroblast Growth Factor Family, which has a Unique Secretion Property

1993 • 390 citations

Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent

1991 • 324 citations

Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1

1994 • 301 citations

Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants.

1991 • 288 citations

Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property.

1993 • 287 citations

Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3.

1992 • 263 citations

Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470)

1994 • 246 citations

Signaling by Receptor Tyrosine Kinases

1993 • 242 citations

Fibroblast growth factor receptors have different signaling and mitogenic potentials

1994 • 214 citations

The cytomegalovirus enhancer: a pan-active control element in transgenic mice.

1990 • 211 citations

Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.

1989 • 210 citations

Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.

1993 • 207 citations

Differential effects of NGF, FGF, EGF, cAMP, and dexamethasone on neurite outgrowth and sodium channel expression in PC12 cells

1990 • 181 citations

Tumor angiogenesis in node-negative breast carcinomas ? relationship with epidermal growth factor receptor, estrogen receptor, and survival

1994 • 176 citations

Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470; AGM-1470).

1993 • 164 citations

MCF-7 breast cancer cells overexpressing transfectedc-erbB-2 have anin vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivityin vivo

1995 • 164 citations

Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction.

1992 • 162 citations

Fibroblast growth factor receptors have different signaling and mitogenic potentials.

1994 • 136 citations

Inhibition by Pentosan Polysulfate (PPS) of Heparin-Binding Growth Factors Released From Tumor Cells and Blockage by PPS of Tumor Growth in Animals

1992 • 127 citations

Fibroblast growth factor 4 transfection of MCF-7 cells produces cell lines that are tumorigenic and metastatic in ovariectomized or tamoxifen-treated athymic nude mice.

1993 • 125 citations

Identification of a cysteine-rich receptor for fibroblast growth factors.

1992 • 124 citations

Localization of basic fibroblast growth factor and transforming growth factor beta 1 in the human mammary gland.

1991 • 123 citations

Cell Type-specific Induction of the Major Immediate Early Enhancer of Human Cytomegalovirus by Cyclic AMP

1990 • 122 citations

Diverse receptors for fibroblast growth factors

1992 • 119 citations

The combination of antiagniogenic agents to inhibit primary tumor growth and metastasis

1993 • 111 citations

Tumor Growth Dependent on Kaposi's Sarcoma-Derived Fibroblast Growth Factor Inhibited by Pentosan Polysulfate

1991 • 106 citations

Emergence of MCF-7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: evidence for a role of EGFR in breast cancer growth and progression.

1994 • 96 citations

MDA-MB-134 breast carcinoma cells overexpress fibroblast growth factor (FGF) receptors and are growth-inhibited by FGF ligands.

1994 • 95 citations

Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ.

1993 • 93 citations

Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease

1994 • 92 citations

Analysis of experimental antiangiogenic therapy

1993 • 87 citations

Scattered micrometastases visualized at the single‐cell level: Detection and re‐isolation of lacZ‐labeled metastasized lymphoma cells

1994 • 68 citations

Significant inhibition of endothelial cell growth in tumor vasculature by an angiogenesis inhibitor, TNP-470 (AGM-1470).

1994 • 68 citations

The Cytomegalovirus Enhancer: a Pan-Active Control Element in Transgenic Mice

1990 • 66 citations

lacZ transduced human breast cancer xenografts as an in vivo model for the study of invasion and metastasis

1992 • 65 citations

Expression of int-2 mRNA in human tumors amplified at the int-2 locus.

1989 • 62 citations

Exploiting the lacZ reporter gene for quantitative analysis of disseminated tumor growth within the brain: use of the lacZ gene product as a tumor antigen, for evaluation of antigenic modulation, and to facilitate image analysis of tumor growth in situ.

1993 • 59 citations

Autocrine growth stimulation by secreted Kaposi fibroblast growth factor but not by endogenous basic fibroblast growth factor.

1990 • 56 citations

Growth stimulation of human breast epithelial cells by basic fibroblast growth factor in serum‐free medium

1989 • 55 citations

Analysis of proteins binding to the proximal promoter region of the human cytomegalovirus IE-1/2 enhancer/promoter reveals both consensus and aberrant recognition sequences for transcription factors Sp1 and CREB

1992 • 54 citations

Expression of multiple species of basic fibroblast growth factor mRNA and protein in normal and tumor-derived mammary epithelial cells in culture.

1991 • 48 citations

The expression of basic fibroblast growth factor and its receptor in cell lines derived from normal human mammary gland and a benign mammary lesion

1993 • 43 citations

Development of Micrometastases: Earliest Events Detected With Bacterial lacZ Gene-Tagged Tumor Cells

1990 • 41 citations

Formation of several specific nucleoprotein complexes on the human cytomegalovirus immediate early enhancer

1991 • 36 citations

Overview of the fibroblast growth factor and receptor families: complexity, functional diversity, and implications for future cardiovascular research

1993 • 36 citations

Disseminating tumor cells and their interactions with leukocytes visualized in the brain.

1992 • 34 citations

Interactions between cellular regulatory proteins and a unique sequence region in the human cytomegalovirus major immediate-early promoter

1990 • 33 citations

Basic fibroblast growth factor stimulates the growth and inhibits casein accumulation in mouse mammary epithelial cells in vitro

1989 • 30 citations

MINIREVIEW: A Role for DNA Methylation in Vertebrate Gene Expression?

1990 • 21 citations

Altered establishment/clearance mechanisms during experimental micrometastasis with live and/or disabled bacterial lacZ-tagged tumor cells.

1992 • 21 citations

Identification of a Cysteine-Rich Receptor for Fibroblast Growth Factors

1992 • 16 citations

Angiogenesis inhibitorO-(chloroacetyl-carbamoyl) fumagillol (TNP-470) inhibits tumor angiogenesis, growth and spontaneous metastasis of MKL- 4 human breast cancer cells in female athymic nude mice

1994 • 15 citations

Mitogenic and dedifferentiating effect of the K-fgf/hst oncogene on rat thyroid PC clone 3 epithelial cells.

1993 • 9 citations

Enhancement of DNA synthesis of human epithelial carcinoma cells by acidic fibroblast growth factor.

1989 • 1 citations