Phenotypic and Functional Analysis of Tumor-Infiltrating Lymphocytes Compared with Tumor-Associated Lymphocytes from Ascitic Fluid and Peripheral Blood Lymphocytes in Patients with Advanced Ovarian Cancer

Lymphocyte responses and cytokines

1994 • 1,860 citations

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

1995 • 554 citations

Distinct Role of Antigen-Specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication in Vivo

1999 • 445 citations

Interleukin 2 regulates its own receptors.

1985 • 414 citations

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

1991 • 406 citations

Interferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytes.

1991 • 402 citations

Human TH1 and TH2 Subsets: Regulation of Differentiation and Role in Protection and Immunopathology

1992 • 383 citations

IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.

1992 • 375 citations

Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity

1996 • 364 citations

Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma.

1993 • 344 citations

Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway.

1991 • 298 citations

Lymphocyte apoptosis induced by Fas ligand- expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytes.

1998 • 238 citations

Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.

1992 • 235 citations

Identification of an IL-10-Producing HLA-DR-Negative Monocyte Subset in the Malignant Ascites of Patients with Ovarian Carcinoma That Inhibits Cytokine Protein Expression and Proliferation of Autologous T Cells

1999 • 172 citations

Interleukin-10 Increases Th1 Cytokine Production and Cytotoxic Potential in Human Papillomavirus-Specific CD8⁺Cytotoxic T Lymphocytes

2000 • 162 citations

Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex.

1995 • 150 citations

T Cell Recognition of Human Tumors: Implications for Molecular Immunotherapy of Cancer

1993 • 137 citations

Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers

1992 • 124 citations

Tumor-host interaction: Analysis of cytokines, growth factors, and tumorinfiltrating lymphocytes in ovarian carcinomas

1997 • 123 citations

Cytokine Dysregulation in Invasive Cervical Carcinoma and Other Human Neoplasias: Time to Consider the TH1/TH2 Paradigm

1998 • 119 citations

Secretion of vascular endothelial growth factor in ovarian cancer.

1999 • 104 citations

Expression of cytokine genes or proteins and signaling molecules in lymphocytes associated with human ovarian carcinoma

1996 • 99 citations

Phenotype, cytokine production and cytolytic capacity of fresh (uncultured) tumour-infiltrating T lymphocytes in human renal cell carcinoma

1997 • 95 citations

Lymphocytes infiltrating human ovarian tumors. I. Role of Leu-19 (NKH1)-positive recombinant IL-2-activated cultures of lymphocytes infiltrating human ovarian tumors.

1988 • 94 citations

Effects of concurrent cisplatinum administration during radiotherapy vs. radiotherapy alone on the immune function of patients with cancer of the uterine cervix

2000 • 92 citations

Separation of tumor-infiltrating lymphocytes from tumor cells in human solid tumors

1986 • 80 citations

CLONAL ANALYSIS OF T LYMPHOCYTES ISOLATED FROM OVARIAN CARCINOMA ASCITIC FLUID. PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF T-CELL CLONES CAPABLE OF LYSING AUTOLOGOUS CARCINOMA CELLS

1985 • 74 citations

Generation of lymphokine-activated killer cells in human ovarian carcinoma ascitic fluid: Identification of transforming growth factor-β as a suppressive factor

1991 • 73 citations

Presentation of renal tumor antigens by human dendritic cells activates tumor-infiltrating lymphocytes against autologous tumor: implications for live kidney cancer vaccines.

1999 • 71 citations

T-cell recognition of ovarian cancer.

1993 • 63 citations

The Stability and Reversibility of Th1 and Th2 Populations

1999 • 60 citations

Induction of ovarian tumor-specific CD8+ cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells

2000 • 58 citations

Expression of Surface Antigens During the Differentiation of Human Dendritic Cells vs Macrophages from Blood Monocytes in vitro

1999 • 55 citations

Down-Regulation of CD25 Expression on the Surface of Activated Tumor-Infiltrating Lymphocytes in Human Cervical Carcinoma

1997 • 50 citations

In vitro induction of tumor-specific human lymphocyte antigen class I–restricted CD8+ cytotoxic T lymphocytes by ovarian tumor antigen–pulsed autologous dendritic cells from patients with advanced ovarian cancer

2000 • 43 citations

Lymphocyte cytotoxicity in the peritoneal cavity and blood of patients with ovarian cancer.

1984 • 42 citations

Reactivation of murine tumour-infiltrating lymphocytes with solid-phase anti-CD3 antibody: in vitro cytokine production is associated with in vivo efficacy

1994 • 35 citations

Interleukin-10 Downregulates Proliferation and Expression of Interleukin-2 Receptor p55 Chain and Interferon-γ, but Not Interleukin-2 or Interleukin-4, by Parasite-Specific Helper T Cell Clones Obtained from Cattle Chronically Infected withBabesia bovisorFasciola hepatica

1995 • 31 citations

Differential expression of T cell differentiation antigens and major histocompatibility antigens on activated T cells during the cell cycle

1986 • 25 citations

Differential effects of an immunosuppressive fraction from ascites fluid of patients with ovarian cancer on spontaneous and antibody-dependent cytotoxicity.

1981 • 24 citations

The usefulness of CD4/CD8 ratio evaluation in monitoring of ovarian cancer patients.

1995 • 15 citations

TNF, LT and IL-1 natural inhibitors (soluble receptors and receptor antagonists) in women with ovarian cancer

1995 • 2 citations