Presentation of renal tumor antigens by human dendritic cells activates tumor-infiltrating lymphocytes against autologous tumor: implications for live kidney cancer vaccines.

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

Generation of mature dendritic cells from human blood An improved method with special regard to clinical applicability

1996 • 1,138 citations

Human neoplasms elicit multiple specific immune responses in the autologous host.

1995 • 1,097 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood

1996 • 696 citations

Decreased antigen presentation by dendritic cells in patients with breast cancer.

1997 • 439 citations

Phase I clinical trial: T-cell therapy for prostate cancer using autologous dendritic cells pulsed with HLA-A0201-specific peptides from prostate-specific membrane antigen

1996 • 398 citations

Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma.

1993 • 385 citations

Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells.

1995 • 324 citations

Induction of antitumor immunity using bone marrow-generated dendritic cells.

1996 • 323 citations

Generation of Mature Dendritic Cells from Human Blood

1997 • 297 citations

Regression of tumors in mice vaccinated with professional antigen-presenting cells pulsed with tumor extracts

1997 • 209 citations

Human CD14+ leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4

1996 • 199 citations

Mechanisms of immune suppression in patients with head and neck cancer: Influence on the immune infiltrate of the cancer

1996 • 178 citations

Inflammatory cells infiltrating human colorectal carcinomas express HLA class II but not B7-1 and B7-2 costimulatory molecules of the T-cell activation.

1996 • 160 citations

S100 positive dendritic cells in human lung tumors associated with cell differentiation and enhanced survival

1993 • 160 citations

Human renal-cell carcinoma tissue contains dendritic cells

1996 • 152 citations

Bone Marrow‐Derived Dendritic Cells Serve as Potent Adjuvants for Peptide‐Based Antitumor Vaccines

1997 • 144 citations

Presentation of prostate tumor antigens by dendritic cells stimulates T-cell proliferation and cytotoxicity

1996 • 120 citations

Interleukin-12 Promotes the Proliferation and Cytolytic Maturation of Immune Effectors

1993 • 101 citations

TGF-β1 pretreatment impairs the allostimulatory function of human bone marrow-derived antigen-presenting cells for both naive and primed T cells

1996 • 72 citations

Anticancer role of dendritic cells (DC) in human and experimental cancers--a review.

1992 • 60 citations

Tumor antigens and tumor vaccines: Peptides as immunogens

1996 • 48 citations

CD4+ T-cells from mice immunized to syngeneic sarcomas recognize distinct, non-shared tumor antigens.

1994 • 44 citations

Liposome-Mediated Cytoplasmic Delivery of Proteins: An Effective Means of Accessing the MHC Class I-Restricted Antigen Presentation Pathway

1994 • 41 citations

Regional immunosuppression in esophageal squamous cancer: evidence from functional studies with matched lymph nodes.

1996 • 41 citations

In vitro migration of lymphocytes through collagen matrix: arrested locomotion in tumor-infiltrating lymphocytes.

1990 • 38 citations

Dendritic cells as specialized antigen-presenting cells

1989 • 33 citations

Renal cell carcinoma: basic biology and current approaches to therapy.

1991 • 32 citations

Cellular therapy: scientific rationale and clinical results in the treatment of metastatic renal-cell carcinoma.

1995 • 31 citations

Differential Activation of Cell-Mediated Immune Functions by Encapsulated and Surface-Linked Liposomal Antigens

1996 • 25 citations

Cytotoxic Activity of CD4⁺ T Cells against Autologous Tumor Cells

1995 • 11 citations