Metabolism and murine pharmacokinetics of the 8-(N,N-dimethylcarboxamide) analogue of the experimental antitumor drug mitozolomide (NSC353451).

Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.

1987 • 386 citations

Antitumour imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, a novel broad-spectrum antitumor agent

1984 • 212 citations

Antitumor imidazotetrazines. 14. Synthesis and antitumor activity of 6- and 8-substituted imidazo[5,1-d]-1,2,3,5-tetrazinones and 8-substituted pyrazolo[5,1-d]-1,2,3,5-tetrazinones

1987 • 66 citations

Activity of mitozolomide (NSC 353451), a new imidazotetrazine, against xenografts from human melanomas, sarcomas, and lung and colon carcinomas.

1985 • 56 citations

Experimental antitumor activity against murine tumor model systems of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one (mitozolomide), a novel broad-spectrum agent.

1985 • 51 citations

Phase II evaluation of mitozolomide in ovarian cancer

1988 • 29 citations

The formation and metabolism of N-hydroxymethyl compounds—III

1983 • 27 citations

5‐[3‐(2‐chloroethyl)‐1‐triazenyl]imidazole‐4‐carboxamide and a Possible Mechanism of Action of 5‐[3,3‐Bis(2‐chloroethyl)‐1‐triazenyl]imidazole‐4‐carboxamide

1975 • 25 citations

Antitumour imidazotetrazines

1985 • 15 citations

Antitumour imidazotetrazines—XVIII

1989 • 9 citations

Antitumour imidazotetrazines, Part IX. The pharmacokinetics of mitozolomide in mice

1985 • 4 citations