GENETIC POLYMORPHISMS IN ETHANOL METABOLISM: ISSUES AND GOALS FOR PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING*

High Blood Alcohol Levels in Women

1990 • 1,248 citations

Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism

1986 • 582 citations

An update on incidence of FAS: FAS is not an equal opportunity birth defect

1995 • 520 citations

Developmental changes and polymorphism in human alcohol dehydrogenase

1971 • 375 citations

CIRRHOSIS IN THE ALCOHOLIC AND ITS RELATION TO THE VOLUME OF ALCOHOL ABUSE

1975 • 348 citations

Clinical Pharmacokinetics of Ethanol

1987 • 273 citations

Genetic and environmental factors affecting ethanol metabolism in man

1971 • 207 citations

Pharmacokinetics of ethanol after oral administration in the fasting state

1977 • 172 citations

Racial Differences in Biological Sensitivity to Ethanol: The Role of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Isozymes

1981 • 160 citations

ADH2 Gene Polymorphisms Are Determinants of Alcohol Pharmacokinetics

1995 • 144 citations

Human liver alcohol dehydrogenase: purification and kinetic characterization of the .beta.2.beta.2, .beta.2.beta.1, .alpha..beta.2, and .beta.2.gamma.1 "Oriental" isoenzymes

1984 • 143 citations

Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients

1997 • 123 citations

Catalytic Properties of Human Liver Alcohol Dehydrogenase Isoenzymes

1987 • 121 citations

Human stomach alcohol and aldehyde dehydrogenases: Comparison of expression pattern and activities in alimentary tract

1997 • 118 citations

Metabolism of Ethanol

1992 • 113 citations

Ethnic Differences in Gastric α‐Alcohol Dehydrogenase Activity and Ethanol First‐Pass Metabolism

1996 • 111 citations

Ethanol metabolism

1987 • 104 citations

Human liver alcohol dehydrogenase: amino acid substitution in the beta 2 beta 2 Oriental isozyme explains functional properties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme.

1984 • 99 citations

Partition coefficients of some acetate esters and alcohols in water, blood, olive oil, and rat tissues.

1994 • 99 citations

Expression and Kinetic Characterization of Recombinant Human Stomach Alcohol Dehydrogenase

1995 • 86 citations

Dose-related effects of a single dose of ethanol on the metabolism in rat liver of some aromatic and chlorinated hydrocarbons

1981 • 86 citations

A Physiologically Based Pharmacokinetic Model for Trichloroethylene and Its Metabolites, Chloral Hydrate, Trichloroacetate, Dichloroacetate, Trichloroethanol, and Trichloroethanol Glucuronide in B6C3F1 Mice

1997 • 86 citations

Alcohol dehydrogenase from human stomach: variability in normal mucosa and effect of age, gender, ADH3 phenotype and gastric region.

1994 • 71 citations

A Comparison of Physiologically Based Pharmacokinetic Model Predictions and Experimental Data for Inhaled Ethanol in Male and Female B6C3F1Mice, F344 Rats, and Humans

1997 • 55 citations

Purification and steady-state kinetic characterization of human liver .beta.3.beta.3 alcohol dehydrogenase

1989 • 45 citations

Pharmacogenetics of alcohol dehydrogenase (ADH)

1990 • 41 citations

Application of a Physiologically Based Pharmacokinetic Model to Estimate the Bioavailability of Ethanol in Male Rats: Distinction between Gastric and Hepatic Pathways of Metabolic Clearance

2000 • 36 citations

Simulation Studies on Ethanol Metabolism in Different Human Populations with a Physiological Pharmacokinetic Model

1993 • 33 citations

Direct determination of usual (Caucasian-type) and atypical (Oriental-type) alleles of the class I human alcohol dehydrogenase-2 locus

1988 • 25 citations

Human liver alcohol dehydrogenase: The unique properties of the “atypical” isoenzyme β2β2-Bern can be explained by a single base mutation

1985 • 12 citations

Characterization of Human Alcohol Dehydrogenases Containing Substitutions at Amino Acids 47 and 51

1990 • 3 citations