Closed structure of phosphoglycerate kinase from Thermotoga maritima reveals the catalytic mechanism and determinants of thermal stability

Accurate bond and angle parameters for X-ray protein structure refinement

1991 • 2,467 citations

Application of a Theory of Enzyme Specificity to Protein Synthesis

1958 • 2,272 citations

Satisfying Hydrogen Bonding Potential in Proteins

1994 • 2,076 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

ALSCRIPT: a tool to format multiple sequence alignments

1993 • 1,125 citations

Enzyme-Catalyzed Phosphoryl Transfer Reactions

1980 • 1,120 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Detection, delineation, measurement and display of cavities in macromolecular structures

1994 • 964 citations

Ion-pairs in proteins

1983 • 687 citations

Protein stability and molecular adaptation to extreme conditons

1991 • 609 citations

Structure of a Hyperthermophilic Tungstopterin Enzyme, Aldehyde Ferredoxin Oxidoreductase

1995 • 534 citations

STRUCTURAL AND GENETIC ANALYSIS OF PROTEIN STABILITY

1993 • 455 citations

Sequence, structure and activity of phosphoglycerate kinase: a possible hinge-bending enzyme

1979 • 452 citations

Stereochemical basis of heat stability in bacterial ferredoxins and in haemoglobin A2

1975 • 420 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Sequence and structure of yeast phosphoglycerate kinase.

1982 • 364 citations

Are buried salt bridges important for protein stability and conformational specificity?

1995 • 323 citations

Thermozymes: Identifying molecular determinants of protein structural and functional stability

1996 • 292 citations

Space-Filling Models of Kinase Clefts and Conformation Changes

1979 • 280 citations

Engineering protein thermal stability

1989 • 276 citations

Binding of nucleotides by proteins

1992 • 274 citations

Structure of a complex between yeast hexokinase A and glucose

1980 • 233 citations

2.0 å structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability

1995 • 224 citations

Space-Filling Models of Kinase Clefts and Conformation Changes: Comparison of the surface structures of kinase enzymes implicates closing clefts in their mechanism.

1979 • 223 citations

The Crystal Structure of Holo-glyceraldehyde-3-phosphate Dehydrogenase from the Hyperthermophilic BacteriumThermotoga maritimaat 2.5 Å Resolution

1995 • 218 citations

Extremely thermostable D-glyceraldehyde-3-phosphate dehydrogenase from the eubacterium Thermotoga maritima

1990 • 211 citations

The hydrophobic effect: a reappraisal

1989 • 211 citations

X‐ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium pyrococcus furiosus

1992 • 190 citations

Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation

1997 • 190 citations

Structure of horse muscle phosphoglycerate kinase

1974 • 189 citations

The crystal structure of citrate synthase from the thermophilic Archaeon, Thermoplasma acidophilum

1994 • 172 citations

Structure and Stability of Hyperstable Proteins: Glycolytic Enzymes From Hyperthermophilic Bacterium Thermotoga Maritima

1996 • 156 citations

Binding of nucleotides by proteins

1992 • 148 citations

Mechanism of phosphate transfer by nucleoside diphosphate kinase: X-ray structures of the phosphohistidine intermediate of the enzymes from Drosophila and Dictyostelium

1995 • 117 citations

Small structural changes account for the high thermostability of 1[4Fe–4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima

1996 • 112 citations

Die automatisierte Faltmolekülmethode

1965 • 111 citations

Stability and folding of ultrastable proteins: eye lens crystalline and enzymes from thermophiles ¹

1996 • 108 citations

Structure of a complex between yeast hexokinase A and glucose

1980 • 108 citations

The Structure of Uridylate Kinase with Its Substrates, Showing the Transition State Geometry

1994 • 79 citations

Analysis of chiral inorganic [16O, 17O, 18O]thiophosphate and the stereochemistry of the 3-phosphoglycerate kinase reaction.

1980 • 75 citations

How to make my blood boil

1995 • 73 citations

The structure of a thermally stable 3‐phosphoglycerate kinase and a comparison with its mesophilic equivalent

1993 • 72 citations

Structure of the ADP complex of the 3-phosphoglycerate kinase from Bacillus stearothermophilus at 1.65 Å

1994 • 70 citations

Phosphoglycerate kinase and triosephosphate isomerase from the hyperthermophilic bacterium Thermotoga maritima form a covalent bifunctional enzyme complex.

1995 • 67 citations

Stereochemical course of the phospho group transfer catalyzed by cAMP-dependent protein kinase

1988 • 63 citations

Structure of the R65Q Mutant of Yeast 3-Phosphoglycerate Kinase Complexed with Mg-AMP-PNP and 3-Phospho-<scp>d</scp>-glycerate^,

1996 • 45 citations

The effect of ion pairs on the thermal stability of D-glyceraldehyde 3-phosphate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima

1994 • 41 citations

2.0 Å resolution structure of a ternary complex of pig muscle phosphoglycerate kinase containing 3-phospho-D-glycerate and the nucleotide Mn adenylylimidodiphosphate

1996 • 40 citations

Cloning, Sequencing, Expression and Characterization of the Gene Encoding the 3- Phosphoglycerate Kinase- Triosephosphate Isomerase Fusionprotein from Thermotoga Maritima

1995 • 14 citations

Crystallographic analysis of phosphoglycerate kinase from the hyperthermophilic bacterium Thermotoga maritima.

1997 • 14 citations

The PGK-TIM Fusion Protein from Thermotoga maritima and Its Constituent Parts Are Intrinsically Stable and Fold Independently

1997 • 11 citations