Engineering protein thermal stability

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Yeasts: Characteristics and Identification

1983 • 1,989 citations

Hydrophobicity of Amino Acid Residues in Globular Proteins

1985 • 1,168 citations

Prediction of chain flexibility in proteins

1985 • 1,123 citations

Interior and surface of monomeric proteins

1987 • 924 citations

Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins

1987 • 637 citations

Further developments of protein secondary structure prediction using information theory

1987 • 573 citations

Thermal stability and protein structure

1979 • 518 citations

Stereochemical basis of heat stability in bacterial ferredoxins and in haemoglobin A2

1975 • 420 citations

The protein identification resource (PIR)

1988 • 389 citations

Relationship of protein flexibility to thermostability

1987 • 296 citations

A new way of enhancing the thermostability of proteases

1986 • 226 citations

An investigation of protein subunit and domain interfaces

1988 • 208 citations

A sensitive procedure to compare amino acid sequences

1987 • 191 citations

A model for the tertiary structure of the 28 residue DNA-binding motif (‘zinc finger’) common to many eukaryotic transcriptional regulatory proteins

1988 • 159 citations

Crystal structure of manganese superoxide dismutase from Bacillus stearothermophilus at 2.4 Å resolution

1988 • 150 citations

Nucleotide sequence of the Escherichia coli gap gene

1985 • 146 citations

Cumulative effect of intragenic amino-acid replacements on the thermostability of a protein

1986 • 128 citations

Heat Stability of a Tetrameric Enzyme, D-Glyceraldehyde-3-PhosphateDehydrogenase

1980 • 119 citations

Analysis of sequence-similar pentapeptides in unrelated protein tertiary structures

1987 • 118 citations

Crystal structure of neutral protease from Bacillus cereus refined at 3.0A˚resolution and comparison with the homologous but more thermostable enzyme thermolysin

1988 • 117 citations

Stabilization of λ repressor against thermal denaturation by site‐directed Gly→Ala changes in α‐helix 3

1986 • 115 citations

Nucleotide sequences of cDNAs coding for rat manganese-containing superoxide dismutase

1987 • 104 citations

An assessment of protein secondary structure prediction methods based on amino acid sequence

1976 • 95 citations

Structure and stability of thermophilic enzymes Studies on thermolysin

1988 • 92 citations

Glyceraldehyde-3-phosphate dehydrogenase gene from Zymomonas mobilis: cloning, sequencing, and identification of promoter region

1987 • 89 citations

PROTEIN THERMOSTABILITY.

1981 • 83 citations

Nucleotide sequence of the gene for aqualysin I (a thermophilic alkaline serine protease) of Thermus aquaticus YT‐1 and characteristics of the deduced primary structure of the enzyme

1988 • 77 citations

Superoxide Dismutase from Thermus aquaticus

1977 • 76 citations

Heat-Stable and Fructose 1,6-Bisphosphate-Activated L-Lactate Dehydrogenase from an Extremely Thermophilic Bacterium1

1982 • 63 citations

Nucleotide sequence and characteristics of the gene for <scp>l</scp>‐lactate dehydrogenase of Thermus caldophilus GK24 and the deduced amino‐acid sequence of the enzyme

1986 • 58 citations

Enhanced heat, alkaline and tryptic stability of acetamidinated pig heart lactate dehydrogenase

1977 • 53 citations

Sequence of a cDNA coding for mouse manganese superoxide dismutase

1986 • 52 citations

Combining thermostable mutations increases the stability of .lambda. repressor

1988 • 49 citations

D-Glyceraldehyde-3-Phosphate Dehydrogenase. The Purification and Characterisation of the Enzyme from the Thermophiles Bacillus stearothermophilus and Thermus aquaticus

1980 • 46 citations

Increasing and decreasing protein stability: Effects of revertant substitutions on the thermal denaturation of phage λ repressor

1985 • 42 citations

Structure and Function of L-Lactate Dehydrogenases from Thermophilic and Mesophilic Bacteria, VI. Nucleotide Sequences of Lactate Dehydrogenase genes from the Thermophilic BacteriaBacillus stearothermophilus, B. caldolyticusandB. caldotenax

1987 • 37 citations

The glyceraldehyde-3-phosphate dehydrogenase gene family in the nematode, Caenorhabditis elegans: Isolation and characterization of one of the genes

1987 • 34 citations

Amino-acid sequence of a tetrameric, manganese superoxide dismutase from Thermus thermopilus HB8

1987 • 28 citations

Structure and Function of L-Lactate Dehydrogenase from Thermophilic, Mesophilic and Psychrophilic Bacteria, VIII. The Primary Structure of the Psychrophilic Lactate Dehydrogenase fromBacillus psychrosaccharolyticus

1987 • 27 citations

Structure and Function of L-Lactate Dehydrogenases from Thermophilic and Mesophilic Bacteria, IV. The Primary Structure of the Mesophilic Lactate Dehydrogenase fromBacillus subtilis

1986 • 26 citations

Structure and Function of L-Lactate Dehydrogenases from Thermophilic and Mesophilic Bacteria VII. Nucleotide Sequence of the Lactate Dehydrogenase Gene from the Mesophilic BacteriumBacillus megaterium.Preparation and Properties of a Hybrid Lactate Dehydrogenase Comprising Moieties of theB. megateriumandB. stearothermophilusEnzymes

1987 • 23 citations

Glyceraldehyde-3-phosphate dehydrogenase genes of Zygosaccharomyces rouxii : The source of a promoter for a host-vector system for Z. rouxii.

1987 • 8 citations