Extracellular Cysteines of CCR5 Are Required for Chemokine Binding, but Dispensable for HIV-1 Coreceptor Activity

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 • 3,106 citations

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

1998 • 2,929 citations

Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 ⁺ T Cells

1995 • 2,890 citations

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1996 • 2,883 citations

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

1996 • 2,326 citations

Human Chemokines: An Update

1997 • 2,235 citations

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1996 • 1,973 citations

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

1996 • 1,678 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

HIV Entry and Its Inhibition

1998 • 1,270 citations

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

1995 • 1,252 citations

CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5

1996 • 1,181 citations

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

1992 • 1,059 citations

A Conserved HIV gp120 Glycoprotein Structure Involved in Chemokine Receptor Binding

1998 • 814 citations

CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

1997 • 722 citations

Molecular Cloning and Functional Expression of a New Human CC-Chemokine Receptor Gene

1996 • 701 citations

Expression cloning of new receptors used by simian and human immunodeficiency viruses

1997 • 692 citations

Molecular cloning of a human cannabinoid receptor which is also expressed in testis

1991 • 679 citations

Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist

1997 • 622 citations

Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4

1997 • 556 citations

Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains

1986 • 471 citations

A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection

1997 • 391 citations

STRL33, A Novel Chemokine Receptor–like Protein, Functions as a Fusion Cofactor for Both Macrophage-tropic and T Cell Line–tropic HIV-1

1997 • 378 citations

Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding

1997 • 363 citations

Epitope Mapping of CCR5 Reveals Multiple Conformational States and Distinct but Overlapping Structures Involved in Chemokine and Coreceptor Function

1999 • 349 citations

A Small-molecule Inhibitor Directed against the Chemokine Receptor CXCR4 Prevents its Use as an HIV-1 Coreceptor

1997 • 335 citations

Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture

1991 • 326 citations

Multiple Extracellular Elements of CCR5 and HIV-1 Entry: Dissociation from Response to Chemokines

1996 • 314 citations

Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses

1997 • 312 citations

Regions in β-Chemokine Receptors CCR5 and CCR2b That Determine HIV-1 Cofactor Specificity

1996 • 298 citations

Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection

1997 • 295 citations

Unwelcomed Guests with Master Keys: How HIV Uses Chemokine Receptors for Cellular Entry

1997 • 260 citations

ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains

1998 • 242 citations

Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1

1997 • 218 citations

Role of extracellular disulfide-bonded cysteines in the ligand binding function of the .beta.2-adrenergic receptor

1990 • 215 citations

HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor

1997 • 203 citations

A Bioluminescent Assay for Agonist Activity at Potentially Any G-Protein-Coupled Receptor

1997 • 201 citations

The Orphan Seven-Transmembrane Receptor Apj Supports the Entry of Primary T-Cell-Line-Tropic and Dualtropic Human Immunodeficiency Virus Type 1

1998 • 200 citations

An Orphan Seven-Transmembrane Domain Receptor Expressed Widely in the Brain Functions as a Coreceptor for Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

1998 • 196 citations

The Second Extracellular Loop of CCR5 Is the Major Determinant of Ligand Specificity

1997 • 183 citations

Exclusive and Persistent Use of the Entry Coreceptor CXCR4 by Human Immunodeficiency Virus Type 1 from a Subject Homozygous for CCR5 Δ32

1998 • 182 citations

Influence of theCCR2-V64IPolymorphism on Human Immunodeficiency Virus Type 1 Coreceptor Activity and on Chemokine Receptor Function of CCR2b, CCR3, CCR5, and CXCR4

1998 • 160 citations

Site-directed Mutagenesis of β-Adrenergic Receptors

1989 • 155 citations

Novel Alleles of the Chemokine-Receptor Gene CCR5

1997 • 149 citations

CD4-Independent Infection by HIV-2 (ROD/B): Use of the 7-Transmembrane Receptors CXCR-4, CCR-3, and V28 for Entry

1997 • 140 citations

Alanine Substitutions of Polar and Nonpolar Residues in the Amino-Terminal Domain of CCR5 Differently Impair Entry of Macrophage- and Dualtropic Isolates of Human Immunodeficiency Virus Type 1

1998 • 128 citations

Site-directed mutagenesis of the rat m1 muscarinic acetylcholine receptor. Role of conserved cysteines in receptor function.

1992 • 126 citations

Continuous monitoring of receptor-mediated changes in the metabolic rates of living cells.

1990 • 124 citations

The high affinity state of the beta 2-adrenergic receptor requires unique interaction between conserved and non-conserved extracellular loop cysteines.

1994 • 123 citations

Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type 1 entry and fusion

1997 • 122 citations

Synthetic full-length and truncated RANTES inhibit HIV-1 infection of primary macrophages

1998 • 82 citations

A Disulfide Bond between Conserved Extracellular Cysteines in the Thyrotropin-releasing Hormone Receptor Is Critical for Binding

1995 • 76 citations

Determinants of HIV-1 Coreceptor Function on CC Chemokine Receptor 3

1997 • 72 citations

The Amino Terminus of Human CCR5 Is Required for Its Function as a Receptor for Diverse Human and Simian Immunodeficiency Virus Envelope Glycoproteins

1998 • 63 citations

CCR5-Mediated Human Immunodeficiency Virus Entry Depends on an Amino-Terminal gp120-Binding Site and on the Conformational Integrity of All Four Extracellular Domains

1999 • 51 citations

Deleted Work

1955 • 0 citations