Opiate receptor supersensitivity produced by chronic naloxone treatment: Dissociation of morphine-induced antinociception and conditioned taste aversion

Experimental Design: Procedures for the Behavioral Sciences

2013 • 8,527 citations

REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I

1966 • 5,429 citations

Experimental Design: Procedures for the Behavioral Sciences.

1969 • 5,180 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Brain dopamine receptors.

1980 • 1,878 citations

Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain

1977 • 1,017 citations

Learning Mechanisms in Food Selection

1978 • 700 citations

Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants.

1978 • 440 citations

Dopaminergic supersensitivity after neuroleptics: Time-course and specificity

1978 • 271 citations

Multiple opiate receptors: Support for unique mu, delta and kappa sites

1982 • 268 citations

Ontogenetic development of [3H]naloxone binding in rat brain

1976 • 239 citations

Mu and delta receptors: Their role in analgesia and in the differential effects of opioid peptides on analgesia

1982 • 233 citations

Aversive conditioning by psychoactive drugs: Effects of morphine, alcohol and chlordiazepoxide

1973 • 210 citations

Multiple opiate receptors: Emerging concepts

1981 • 201 citations

Narcotic Receptor Sites in Morphine-dependent Rats

1974 • 201 citations

Multiple opiate receptors: Differential binding of μ, κ and δ agonists

1981 • 201 citations

Naltrexone-induced opiate receptor supersensitivity

1982 • 195 citations

Chronic naloxone results in prolonged increases in opiate binding sites in brain

1978 • 169 citations

Regulation of neocortical muscarinic receptors: effects of drug treatment and lesions

1982 • 155 citations

Opioid peptides induce reduction of enkephalin receptors in cultured neuroblastoma cells

1982 • 130 citations

Enhanced analgesic effects of morphine after chronic administration of naloxone in the rat

1978 • 128 citations

Scopolamine induces an increase in muscarinic receptor level in rat hippocampus

1980 • 120 citations

Effect of antenatal exposure to opiates on the development of opiate receptors in rat brain

1980 • 118 citations

Binding of 3H-naloxone in the mouse brain: Effect of ions and tolerance development

1974 • 113 citations

Supersensitivity to opioids following the chronic blockade of endorphin action by naloxone

1979 • 109 citations

Both ν and δ Opiate Receptors Exist on the Same Neuron

1981 • 96 citations

Antagonism of morphine-induced aversive conditioning by naloxone

1975 • 94 citations

Conditioned preferences in the rat with an unnatural need state: Morphine withdrawal.

1973 • 90 citations

Analgesic activity of intracerebroventricular administration of morphiceptin and β-casomorphins: Correlation with the morphine (μ) receptor binding affinity

1982 • 90 citations

Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment

1982 • 87 citations

Discrimination of three opiate receptor binding sites with the use of a computerized curve-fitting technique.

1982 • 86 citations

Stereospecific aversive property of narcotic antagonists in morphine-free rats

1978 • 81 citations

Chronic naltrexone increases opiate binding in brain and produces supersensitivity to morphine in the locus coeruleus of the rat

1983 • 81 citations

Modification of the punishing effects of psychoactive drugs in rats by previous drug experience.

1975 • 78 citations

Temporal analysis of naloxone attenuation of morphine-induced taste aversion

1977 • 77 citations

Attenuation of punishing effects of morphine and amphetamine by chronic prior treatment.

1974 • 73 citations

Structure-activity relationships of enkephalin analogs at opiate and enkephalin receptors: Correlation with analgesia

1980 • 72 citations

Development of Rat Spinal Cord

1979 • 66 citations

CHARACTERISTICS AND REGIONAL DISTRIBUTIONS OF TWO DISTINCT [³H]NALOXONE BINDING SITES IN THE RAT BRAIN

1978 • 62 citations

Morphine-induced taste aversions: A consideration of parameters

1978 • 58 citations

Neurons in the frontal cortex of the rat carry multiple opiate receptors

1981 • 51 citations

Chronic continuous administration of neuroleptic drugs alters cerebral dopamine receptors and increases spontaneous dopaminergic action in the striatum

1982 • 48 citations

Morphine injections in the taste aversion paradigm

1976 • 48 citations

Reduction of opiate binding to brainstem slices associated with the development of tolerance to morphine in rats.

1979 • 48 citations

Drug pretreatment effects in drug induced taste aversions: Effects of dose and duration of pretreatment

1976 • 47 citations

Possible involvement of central factors in the mediation of conditioned taste aversion

1977 • 37 citations

Age-related differences in the effect of chronic administration of naloxone on opiate binding in rat brain

1983 • 36 citations

The effect of N-allylnormorphine upon the development of tolerance to morphine in the albino rat.

1953 • 34 citations

An improved long-acting delivery system for narcotic antagonists

1978 • 29 citations

Saturable binding of morphine to rat brain-stem slices and the effect of chronic morphine treatment.

1975 • 25 citations

Rhythmic nature of naloxone-induced aversions and nociception in rats

1982 • 22 citations

Sensitization produced by repeated administration of naloxone is blocked by food deprivation.

1982 • 17 citations

Enkephalin and α-adrenergic receptors: Evidence for both common and differentiable regulatory pathways and down-regulation of the enkephalin receptor

1982 • 14 citations

In vivo binding of 3H-etorphine in morphine-dependent rats

1982 • 13 citations

Alterations of synaptic high and low affinity opiate binding sites after acute and chronic morphine administration in mice

1982 • 13 citations

Electrophysiologic assessment of receptor changes following chronic drug treatment.

1981 • 10 citations

An aversive naloxone-morphine interaction in rats

1983 • 10 citations

Demonstration of opiate receptor sub-types

1982 • 4 citations