Transglutaminase-dependent RhoA Activation and Depletion by Serotonin in Vascular Smooth Muscle Cells

Rho GTPases in cell biology

2002 • 4,662 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

2000 • 1,427 citations

Transglutaminases: crosslinking enzymes with pleiotropic functions

2003 • 1,379 citations

Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase

1998 • 1,034 citations

Role of Akt Signaling in Vascular Homeostasis and Angiogenesis

2002 • 981 citations

Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

1998 • 933 citations

Transglutaminase 2: an enigmatic enzyme with diverse functions

2002 • 551 citations

Rho Kinases in Cardiovascular Physiology and Pathophysiology

2006 • 533 citations

Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for Degradation

2003 • 532 citations

Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension

2001 • 506 citations

Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine

1997 • 492 citations

Regulation of PTEN by Rho small GTPases

2005 • 475 citations

Rho GTPases, Statins, and Nitric Oxide

2005 • 463 citations

Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension

2001 • 450 citations

Serotonylation of Small GTPases Is a Signal Transduction Pathway that Triggers Platelet α-Granule Release

2003 • 444 citations

The insulin receptor: structure, function, and signaling

1994 • 434 citations

Phosphoinositide 3-kinase signalling – which way to target?

2003 • 412 citations

Rho GTPase/Rho Kinase Negatively Regulates Endothelial Nitric Oxide Synthase Phosphorylation through the Inhibition of Protein Kinase B/Akt in Human Endothelial Cells

2002 • 399 citations

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Isoprenylation Inhibitors Induce Apoptosis of Vascular Smooth Muscle Cells in Culture

1998 • 395 citations

Gene Disruption of Tissue Transglutaminase

2001 • 337 citations

Stimulation of aortic smooth muscle cell mitogenesis by serotonin.

1986 • 327 citations

Inhibition of Rho-Kinase Leads to Rapid Activation of Phosphatidylinositol 3-Kinase/Protein Kinase Akt and Cardiovascular Protection

2004 • 322 citations

Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface

2002 • 317 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

1990 • 314 citations

CNF1 Exploits the Ubiquitin-Proteasome Machinery to Restrict Rho GTPase Activation for Bacterial Host Cell Invasion

2002 • 284 citations

Human Urotensin II–Induced Contraction and Arterial Smooth Muscle Cell Proliferation Are Mediated by RhoA and Rho-Kinase

2001 • 263 citations

Rho as a Mediator of G Protein-Coupled Receptor Signaling

1999 • 244 citations

Differential expression of tissue transglutaminase in human cells

1989 • 226 citations

Induction of Serotonin Transporter by Hypoxia in Pulmonary Vascular Smooth Muscle Cells

1999 • 208 citations

Rho Kinase–Induced Nuclear Translocation of ERK1/ERK2 in Smooth Muscle Cell Mitogenesis Caused by Serotonin

2004 • 183 citations

1α,25-Dihydroxyvitamin D ₃ Induces Vascular Smooth Muscle Cell Migration via Activation of Phosphatidylinositol 3-Kinase

2002 • 161 citations

The Rho-deamidating Cytotoxic Necrotizing Factor 1 fromEscherichia coli Possesses Transglutaminase Activity

1998 • 160 citations

Cytoskeletal Effects of Rho-Like Small Guanine Nucleotide–Binding Proteins in the Vascular System

2001 • 155 citations

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension

2005 • 144 citations

Phosphorylation of Serine 188 Protects RhoA from Ubiquitin/Proteasome-Mediated Degradation in Vascular Smooth Muscle Cells

2005 • 142 citations

Fasudil, a Rho-Kinase Inhibitor, Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm in Apolipoprotein E–Deficient Mice by Inhibiting Apoptosis and Proteolysis

2005 • 128 citations

Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells

2003 • 120 citations

Regulation of Vascular Smooth Muscle Cell Apoptosis

1999 • 102 citations

Post-translational Processing of RhoA

1997 • 93 citations

Serotonin-Induced Growth of Pulmonary Artery Smooth Muscle Requires Activation of Phosphatidylinositol 3-Kinase/Serine-Threonine Protein Kinase B/Mammalian Target of Rapamycin/p70 Ribosomal S6 Kinase 1

2005 • 92 citations

Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2

2001 • 84 citations

Chronic hypoxia augments protein kinase G-mediated Ca²⁺ desensitization in pulmonary vascular smooth muscle through inhibition of RhoA/Rho kinase signaling

2004 • 83 citations

HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells

2002 • 82 citations

Sildenafil Prevents Change in RhoA Expression Induced by Chronic Hypoxia in Rat Pulmonary Artery

2003 • 72 citations

Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization

2000 • 72 citations

Short-Term Pravastatin Mediates Growth Inhibition and Apoptosis, Independently of Ras, via the Signaling Proteins p27Kip1 and PI3 Kinase

1999 • 69 citations

Thrombospondin and fibrinogen bind serotonin-derivatized proteins on COAT-platelets

2002 • 63 citations

Phosphatidylinositol 3-Kinase Is Required for Growth Factor–Induced Amino Acid Uptake by Vascular Smooth Muscle Cells

1999 • 62 citations

Rho-Kinase Inhibition Reduces Neointima Formation after Vascular Injury by Enhancing Bax Expression and Apoptosis

2003 • 39 citations

Serotonin uptake and configurational change of bovine pulmonary artery smooth muscle cells in culture

1989 • 26 citations

Transglutaminase 2 in celiac disease: Minireview article

2004 • 20 citations

A Role for Rho in Smooth Muscle Phenotypic Regulation

2001 • 19 citations