Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat
Data up to Jan 2025
Total Citations Per Year
Abstract
References (48)
The Rat Brain in Stereotaxic Coordinates
1982 • 53,055 citations
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice
1999 • 3,597 citations
Drugs of abuse: anatomy, pharmacology and function of reward pathways
1992 • 2,091 citations
Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
1996 • 1,083 citations
The dopamine hypothesis of reward: past and current status
1999 • 981 citations
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
1988 • 913 citations
Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.
1995 • 857 citations
The pharmacology of mesolimbic dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and nucleus accumbens of the rat brain
1996 • 376 citations
Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.
1993 • 369 citations
GABA and enkephalin projection from the nucleus accumbens and ventral pallidum to the ventral tegmental area
1993 • 349 citations
Antispasticity drugs: Mechanisms of action
1985 • 339 citations
Regulation of somatodendritic dopamine release in the ventral tegmental area by opioids and GABA: an in vivo microdialysis study
1992 • 311 citations
Modulation of A10 dopamine neurons by gamma-aminobutyric acid agonists.
1990 • 265 citations
Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics
2002 • 259 citations
GABAB receptor agonists for the treatment of drug addiction: a review of recent findings
2002 • 240 citations
Ability of Baclofen in Reducing Alcohol Intake and Withdrawal Severity: I—Preclinical Evidence
2000 • 202 citations
A novel strategy for the treatment of cocaine addiction
1998 • 196 citations
Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats
1996 • 196 citations
Ability of Baclofen in Reducing Alcohol Craving and Intake: II—Preliminary Clinical Evidence
2000 • 193 citations
A pharmacologic strategy for the treatment of nicotine addiction
1999 • 176 citations
Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release.
1999 • 172 citations
A POTENTIAL ROLE FOR GABAB AGONISTS IN THE TREATMENT OF PSYCHOSTIMULANT ADDICTION
2002 • 165 citations
Response of nicotine self-administration in the rat to manipulations of mu-opioid and γ-aminobutyric acid receptors in the ventral tegmental area
2000 • 154 citations
The pharmacology of mesocortical dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and prefrontal cortex of the rat brain.
1998 • 151 citations
Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure
1997 • 150 citations
Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules
2000 • 149 citations
The GABAB agonist baclofen modifies cocaine self-administration in rats.
1998 • 139 citations
Rapid suppression of alcohol withdrawal syndrome by baclofen
2002 • 124 citations
GABAergic MECHANISMS OF OPIATE REINFORCEMENT
2002 • 117 citations
The role of afferents to the ventral tegmental area in the handling stress-induced increase in the release of dopamine in the medial prefrontal cortex: a dual-probe microdialysis study in the rat brain
1998 • 109 citations
GABA mechanisms in the pedunculopontine tegmental nucleus influence particular aspects of nicotine self-administration selectively in the rat
2001 • 98 citations
Effects of pharmacologic increases in brain GABA levels on cocaine-induced changes in extracellular dopamine
1998 • 98 citations
BACLOFEN ANTAGONIZES INTRAVENOUS SELF-ADMINISTRATION OF NICOTINE IN MICE AND RATS
2002 • 97 citations
Increased mesolimbic GABA concentration blocks heroin self-administration in the rat.
2000 • 95 citations
Gamma-vinyl GABA inhibits methamphetamine, heroin, or ethanol-induced increases in nucleus accumbens dopamine
1999 • 95 citations
Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats
1996 • 90 citations
Opposite changes in the mesolimbic dopamine metabolism in the nerve terminal and cell body sites induced by locally infused baclofen in the rat
1994 • 88 citations
Baclofen decreases methamphetamine self-administration in rats
2002 • 85 citations
Double-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal
2000 • 77 citations
Chlordiazepoxide alters intravenous cocaine self-administration in rats
1989 • 65 citations
Stereospecific actions of baclofen on sociosexual behavior, locomotor activity and motor execution
1989 • 56 citations
Effects of Ventral Tegmental Microinjections of the GABAA Agonist Muscimol on Self-Administration of Ethanol and Sucrose
1996 • 52 citations
Effects of a single dose of baclofen on self-reported subjective effects and tobacco smoking
2001 • 52 citations
Effects of a single dose of baclofen on self-reported subjective effects and tobacco smoking
2001 • 52 citations
Both GABAB receptor agonist and antagonists decreased brain stimulation reward in the rat
2001 • 51 citations
Ability of Baclofen in Reducing Alcohol Intake and Withdrawal Severity: I???Preclinical Evidence
2000 • 34 citations
Baclofen antagonises intravenous self-administration of γ-hydroxybutyric acid in mice
2001 • 30 citations
Double-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal
2008 • 6 citations