Interferon-gamma: A Review

Virus interference. I. The interferon

1957 • 3,331 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

1983 • 1,918 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

Response of resting human peripheral blood natural killer cells to interleukin 2.

1984 • 616 citations

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1984 • 529 citations

Role of NK cells in tumour growth and metastasis in beige mice

1980 • 524 citations

The Biochemistry, Biology, and Role of Interleukin 2 in the Induction of Cytotoxic T Cell and Antibody-Forming B Cell Responses

1982 • 524 citations

Structure of the human immune interferon gene

1982 • 510 citations

Antigen presentation: comments on its regulation and mechanism.

1984 • 498 citations

Effect of interleukin 2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta.

1985 • 492 citations

Regulation of murine macrophage Ia antigen expression by a lymphokine with immune interferon activity.

1982 • 481 citations

Regulation of the production of immune interferon and cytotoxic T lymphocytes by interleukin 2.

1981 • 477 citations

Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity.

1984 • 471 citations

Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm

1987 • 464 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells

1984 • 432 citations

The biology of the interferon system 1984

1985 • 413 citations

Quantitative studies on viral interference in suspended L cells

1962 • 395 citations

Preferential effect of γ interferon on the synthesis of HLA antigens and their mRNAs in human cells

1982 • 386 citations

Close link between reduction of c-myc expression by interferon and G0/G1 arrest

1985 • 358 citations

The Interferon Genes

1986 • 304 citations

Interferon-activated genes

1986 • 301 citations

Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes

1987 • 301 citations

Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon gamma production.

1983 • 288 citations

Differential efficacies of human type I and type II interferons as antiviral and antiproliferative agents.

1980 • 286 citations

High-affinity binding of 125I-labelled mouse interferon to a specific cell surface receptor

1980 • 275 citations

Interferon: An Inducer of Macrophage Activation by Polyanions

1977 • 275 citations

Human leukocyte and fibroblast interferons are structurally related

1980 • 273 citations

Quantitative variation in la antigen expression plays a central role in immune regulation

1984 • 270 citations

Antigen-presenting capabilities of human monocytes correlates with their expression of HLA-DS, an Ia determinant distinct from HLA-DR.

1983 • 260 citations

Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection.

1976 • 254 citations

A T cell-independent mechanism of macrophage activation by interferon-gamma.

1987 • 239 citations

γ-Interferon is one of several direct B cell-maturing lymphokines

1984 • 237 citations

A unique set of polypeptides is induced by γ interferon in addition to those induced in common with α and β interferons

1983 • 234 citations

Interferon-gamma induces enhanced expression of Ia and H-2 antigens on B lymphoid, macrophage, and myeloid cell lines.

1983 • 228 citations

Purified human immune interferon has more potent anticellular activity than fibroblast or leukocyte interferon

1980 • 221 citations

Interferons as macrophage-activating factors. III. Preferential effects of interferon-gamma on the interleukin 1 secretory potential of fresh or aged human monocytes.

1985 • 217 citations

Functional identity between murine γ Interferon and macrophage activating factor

1983 • 206 citations

Role of γ-interferon in antibody-producing responses

1984 • 203 citations

Immune interferon release when a cloned cytotoxic T-cell line meets its correct influenza-infected target cell

1982 • 202 citations

Interferons and the immune system

1980 • 194 citations

Antiviral activity of the pregnancy recognition hormone ovine trophoblast protein-1

1988 • 191 citations

Human immune interferon gene is located on chromosome 12.

1983 • 173 citations

Inhibition of B lymphocyte activation by interferon-gamma.

1987 • 164 citations

A differentiation factor required for the expression of cytotoxic T-cell function

1982 • 163 citations

Potentiation of interferon activity by mixed preparations of fibroblast and immune interferon

1979 • 156 citations

Human chromosomes 6 and 21 are required for sensitivity to human interferon gamma.

1987 • 146 citations

Immune interferon and leukocyte-conditioned medium induce normal and leukemic myeloid cells to differentiate along the monocytic pathway.

1983 • 146 citations

Selective reduction of c-myc mRNA in Daudi cells by human beta interferon.

1984 • 142 citations

Cloning and expression of the chromosomal immune interferon gene of the rat.

1985 • 139 citations

Cellular origin and interactions involved in gamma-interferon production induced by OKt3 monoclonal antibody.

1982 • 129 citations

Production of immune interferon by murine T-cell clones from long-term cultures

1981 • 125 citations

Interaction of interferon with cellular receptors. Internalization and degradation of cell-bound interferon.

1982 • 125 citations

The determination of an immunologically active dose of interferon-gamma in patients with melanoma.

1988 • 123 citations

Phase I trial of recombinant interferon gamma in cancer patients.

1986 • 121 citations

Antitumor effects of interferon in mice injected with interferon‐sensitive and interferon‐resistant friend leukemia cells. I.

1982 • 112 citations

Human interferon-gamma is internalized and degraded by cultured fibroblasts.

1983 • 112 citations

Potentiation of the direct anticellular activity of mouse interferons: mutual synergism and interferon concentration dependence.

1982 • 110 citations

Tumor Necrosis Factor Reduces c- myc Expression and Cooperates with Interferon-γ in HeLa Cells

1986 • 109 citations

Interferon enhances the expression of Fc gamma receptors.

1980 • 104 citations

Interferons, a group of multiple lymphokines

1984 • 103 citations

Immune (γ) interferon produced by a human T-lymphoblast cell line

1981 • 99 citations

Anti‐interferon‐γ antibody protects mice against the generalized Shwartzman reaction

1987 • 95 citations

Abrogation of species specificity for activation of tumoricidal properties in macrophages by recombinant mouse or human interferon-gamma encapsulated in liposomes.

1985 • 95 citations

Human T cells from autoimmune and normal individuals can produce tumor necrosis factor

1987 • 94 citations

Purification of two subspecies of human gamma (immune) interferon.

1982 • 90 citations

Activation or suppression of the tumoricidal properties of monocytes from cancer patients following treatment with human recombinant gamma-interferon.

1986 • 86 citations

Interferon production by human and murine lymphocytes in response to alloantigens.

1980 • 86 citations

Signal requirements in the step-wise functional maturation of cytotoxic T lymphocytes

1987 • 84 citations

Vasopressin replacement of interleukin 2 requirement in gamma interferon production: lymphokine activity of a neuroendocrine hormone.

1982 • 81 citations

Recombinant interferon-gamma inhibits the B cell proliferative response stimulated by soluble but not by Sepharose-bound anti-immunoglobulin antibody.

1985 • 77 citations

Phase I/II Study of Recombinant Interferon Gamma in Advanced Renal Cell Carcinoma

1988 • 77 citations

Marked Disparity in Incidence of Bacterial Infections in Patients with the Acquired Immunodeficiency Syndrome Receiving Interleukin-2 or Interferon-γ

1988 • 74 citations

Direct cytolysis by partially‐purified preparations of immune interferon

1982 • 74 citations

Intracellular human gamma-interferon triggers an antiviral state in transformed murine L cells.

1987 • 74 citations

Selective Increase in Lymphocyte Interferon Response to Vaccinia Antigen after Revaccination

1972 • 71 citations

Biological effects of γ‐interferon on human tumor cells: Quantity and affinity of cell membrane receptors for γ‐IFN in relation to growth inhibition and induction of HLA‐DR expression

1985 • 71 citations

Quantitative representation of all T cells committed to develop into cytotoxic effector cells and/or interleukin 2 activity‐producing helper cells within murine T lymphocyte subsets

1984 • 69 citations

Effects of glycosidase treatment on the physicochemical properties and biological activity of human interferon-gamma.

1983 • 68 citations

Potentiation of lymphocyte natural killing by mixtures of alpha or beta interferon with recombinant gamma interferon

1983 • 67 citations

Immunoregulation and natural killer cells

1982 • 64 citations

Antitumor effects of interferon in mice injected with interferon‐sensitive and interferon‐resistant friend leukemia cells. III. Inhibition of growth and necrosis of tumors implanted subcutaneously

1983 • 64 citations

Sequence and structural homologies among type I and type II interferons

1982 • 58 citations

Unexpectedly rapid action of human interferon in physiological conditions

1975 • 58 citations

Clustering of Leukocyte and Fibroblast Interferon Genes of Human Chromosome 9

1982 • 58 citations

HLA DR, DQ, and DP antigen expression in rheumatoid synovial cells: a biochemical and quantitative study.

1987 • 57 citations

Interferons and the immune system

1985 • 55 citations

Synergistic effects of recombinant tumour necrosis factor and interferon-gamma on rat thyroid cell growth and Ia antigen expression.

1988 • 55 citations

Cell proliferation: Interferons and oncogenes

1985 • 51 citations

Generation of alloreactive cytotoxic T lymphocytes: evidence for a differentiation factor distinct from IL 2.

1983 • 50 citations

Interferon nomenclature.

1980 • 49 citations

Interferon inhibits the generation of allospecific suppressor T lymphocytes.

1982 • 44 citations

Inhibition of reovirus messenger RNA methylation in extracts of interferon-treated ehrlich ascites tumor cells

1975 • 44 citations

Production of immune interferon by an interleukin 2-independent murine T cell line.

1982 • 43 citations

Obligatory role of gamma interferon in T cell-replacing factor-dependent, antigen-specific murine B cell responses.

1985 • 43 citations

Reovirus Infection Enhances Expression of Class I MHC Proteins on Human β-Cell and Rat RINm5F cell

1988 • 42 citations

Effects of human γ interferon on cell growth, replication of virus and induction of 2′‐5′oligoadenylate synthetase in three human lymphoblastoid cell lines and K562 cells

1982 • 40 citations

Concepts in Viral Pathogenesis

1985 • 39 citations

Results of a phase-II clinical trial on treatment of rheumatoid arthritis with recombinant interferon-gamma

1987 • 38 citations

A Phase II Study of the Efficacy of Recombinant Interferon Gamma in Relapsing Ovarian Adenocarcinoma

1988 • 36 citations

Interferon-gamma: success, structure and speculation

1982 • 34 citations

Interferons and Inflammation

1987 • 34 citations

Requirement for three distinct lymphokines for the induction of cytotoxic T lymphocytes from thymocytes.

1986 • 33 citations

Expression of myeloid and major histocompatibility antigens on small cell carcinoma of the lung cell lines analyzed by cytofluorography: modulation by gamma-interferon.

1986 • 33 citations

Inducer T-cell-mediated killing of antigen-presenting cells

1986 • 30 citations

Release of discrete interferons by cytotoxic T lymphocytes in response to immune and nonimmune stimuli.

1984 • 29 citations

IL-2- and IFNγ-enhanced natural cytotoxic activity: Analysis of the role of different lymphoid subsets and implications for activation routes

1986 • 29 citations

In VivoAugmentation of Natural Killer Activity by Combined Treatment with Recombinant Gamma Interferon and Interleukin-2

1985 • 26 citations

A preliminary Phase I trial of partially purified interferon-gamma in patients with cancer.

1984 • 25 citations

Characteristics of Alloantigens and Cellular Mechanisms Responsible for Gamma-Interferon Production in Primary Murine MLC

1981 • 22 citations

The effect of interferon-gamma treatment of rat tumour cells on their susceptibility to natural killer cell, macrophage and cytotoxic T-cell killing.

1988 • 21 citations

Immune (y) Interferon Produced by Murine T-Cell Lymphomas

1983 • 21 citations

Immune interferon induction by a monoclonal antibody specific for human T cells

1981 • 20 citations

Interferon- Induces Altered Oncogene Expression and Terminal Differentiation in A431 Cells

1987 • 20 citations

Analysis of deficiencies in IFN-gamma-mediated priming for tumor cytotoxicity in peritoneal macrophages from A/J mice.

1986 • 20 citations

Immune (y) interferon production by murine T cell lymphomas.

1982 • 19 citations

Analysis of receptors, cell surface antigens, and proteins in human melanoma cell lines resistant to human recombinant beta- or gamma-interferon.

1986 • 18 citations

Successful treatment of colon cancer in rats with recombinant interferon-gamma

1987 • 17 citations

Triggering of interferon γ-primed macrophages by various known complement activators for nonspecific tumor cytotoxicity

1987 • 15 citations

Reovirus infection enhances expression of class I MHC proteins on human beta-cell and rat RINm5F cell

1988 • 15 citations

In VivoAntiviral Activity of Recombinant Murine Gamma Interferon

1985 • 14 citations

Immune regulation of the L5178Y murine tumor-dormant state. II. Interferon-gamma requires tumor necrosis factor to restrain tumor cell growth in peritoneal cell cultures from tumor-dormant mice.

1987 • 11 citations

Gamma-interferon production by human low-density lymphocytes induced by T-cell mitogens.

1986 • 11 citations

ENHANCEMENT OF NATURAL KILLING ACTIVITY BY DIFFERENT TYPES OF INTERFERON

1982 • 9 citations

Augmentation of lymphokine-activated killer cell activity in patients with gastrointestinal cancer

1988 • 9 citations

Recombinant interferon gamma in rheumatoid arthritis. A double-blind study comparing immuneron (recombinant interferon gamma) with placebo

1988 • 7 citations

Interferon and Viral Pathogenesis

1984 • 6 citations

Macrophage activation factor from EL-4, a murine T-cell line: Antigenic characterization by hamster monoclonal antibodies to murine interferon-γ

1987 • 2 citations