Pervanadate simulates the effects of interleukin-2 (IL-2) in human T cells and provides evidence for the activation of two distinct tyrosine kinase pathways by IL-2.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells.

1990 • 440 citations

Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

1989 • 317 citations

Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events.

1993 • 312 citations

The hematopoietin receptor superfamily

1993 • 296 citations

T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck.

1991 • 218 citations

Isolation of human mononuclear cell subsets by counterflow centrifugal elutriation (CCE)

1984 • 218 citations

Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.

1992 • 173 citations

Activation of a tyrosine protein kinase is an early event in the stimulation of T lymphocytes by interleukin-2.

1988 • 152 citations

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

1993 • 138 citations

Prolactin receptor triggering. Evidence for rapid tyrosine kinase activation.

1992 • 137 citations

Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R.

1992 • 135 citations

Interleukin 2 induces a rapid increase in intracellular pH through activation of a Na+/H+ antiport. Cytoplasmic alkalinization is not required for lymphocyte proliferation.

1985 • 114 citations

Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line.

1992 • 103 citations

Two-dimensional Analysis of Interleukin 2-Regulated Tyrosine Kinase Activation Mediated by the p70-75 β Subunit of the Interleukin 2 Receptor

1989 • 79 citations

IL-2 regulation of tyrosine kinase activity is mediated through the p70-75 beta-subunit of the IL-2 receptor.

1989 • 65 citations

A tyrosine kinase physically associates with the β-subunit of the human IL-2 receptor

1991 • 62 citations

Association of the erythropoietin receptor with protein tyrosine kinase activity.

1992 • 56 citations

Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase.

1994 • 55 citations

A tyrosine kinase physically associates with the beta-subunit of the human IL-2 receptor.

1991 • 51 citations

Characterization of a 97-kDa phosphotyrosylprotein regulated by multiple cytokines.

1992 • 44 citations

Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit.

1993 • 23 citations

Regulation of the interleukin 2 receptor complex tyrosine kinase activity in vitro

1991 • 17 citations

Characterization of a tyrosine kinase activity associated with the high-affinity interleukin 2 receptor complex

1992 • 15 citations

Comparative analysis of IL-2 and IL-3 induced tyrosine phosphorylation.

1989 • 14 citations

Interleukin-2-dependent phosphorylation of the retinoblastoma-susceptibility-gene product p110-115RB in human T-cells

1992 • 10 citations