bcl-2 Messenger RNA is localized in neurons of the developing and adult rat brain

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study

1983 • 1,082 citations

Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.

1990 • 993 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family

1990 • 817 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

Widespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons

1990 • 529 citations

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.

1986 • 525 citations

Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.

1992 • 515 citations

The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures

1987 • 379 citations

Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen

1989 • 376 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

Cellular localization of nerve growth factor synthesis by in situ hybridization.

1987 • 345 citations

Brain‐derived Neurotrophic Factor is a Survival Factor for Cultured Rat Cerebellar Granule Neurons and Protects them Against Glutamate‐induced Neurotoxicity

1993 • 287 citations

Cells that Express Brain‐Derived Neurotrophic Factor mRNA in the Developing Postnatal Rat Brain

1991 • 208 citations

Molecular analysis of mbcl-2: Structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma

1987 • 200 citations

Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma.

1987 • 191 citations

Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cells.

1993 • 147 citations

Isolation and characterization of the chickenbcl–2gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo

1992 • 118 citations

In Vitro and in Vivo Methods for Evaluating Actions of Cytokines on Nerve Growth Factor Production in Central Nervous System

1993 • 12 citations