Macrophages and Microglia Produce Local Trophic Gradients That Stimulate Axonal Sprouting Toward but Not beyond the Wound Edge

Degeneration and Regeneration of the Nervous System.

1929 • 2,924 citations

Chondroitinase ABC promotes functional recovery after spinal cord injury

2002 • 2,236 citations

The glial scar and central nervous system repair

1999 • 1,757 citations

In vitro methods in cell-mediated and tumor immunity

1976 • 1,266 citations

Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion

1994 • 912 citations

Depletion of Hematogenous Macrophages Promotes Partial Hindlimb Recovery and Neuroanatomical Repair after Experimental Spinal Cord Injury

1999 • 686 citations

cAMP-induced switching in turning direction of nerve growth cones

1997 • 614 citations

Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo

1995 • 583 citations

Lens Injury Stimulates Axon Regeneration in the Mature Rat Optic Nerve

2000 • 570 citations

Activated Macrophages and Microglia Induce Dopaminergic Sprouting in the Injured Striatum and Express Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor

1999 • 569 citations

Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC

2001 • 562 citations

Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma.

1999 • 561 citations

Neuronal Chemotaxis: Chick Dorsal-Root Axons Turn Toward High Concentrations of Nerve Growth Factor

1979 • 522 citations

Functional regeneration of sensory axons into the adult spinal cord

2000 • 517 citations

Injury-Induced Proteoglycans Inhibit the Potential for Laminin-Mediated Axon Growth on Astrocytic Scars

1995 • 487 citations

BDNF and NT-4/5 Prevent Atrophy of Rat Rubrospinal Neurons after Cervical Axotomy, Stimulate GAP-43 and Tα1-Tubulin mRNA Expression, and Promote Axonal Regeneration

1997 • 477 citations

NG2 Is a Major Chondroitin Sulfate Proteoglycan Produced after Spinal Cord Injury and Is Expressed by Macrophages and Oligodendrocyte Progenitors

2002 • 474 citations

The Chondroitin Sulfate Proteoglycans Neurocan and Phosphacan Are Expressed by Reactive Astrocytes in the Chronic CNS Glial Scar

1999 • 473 citations

Neurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes

2000 • 472 citations

Adrenal Medulla Grafts Enhance Recovery of Striatal Dopaminergic Fibers

1987 • 398 citations

Endogenous Repair after Spinal Cord Contusion Injuries in the Rat

1997 • 398 citations

Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity

1983 • 389 citations

Axonal Regeneration and Functional Recovery after Complete Spinal Cord Transection in Rats by Delayed Treatment with Transplants and Neurotrophins

2001 • 378 citations

Morphological response of axotomized septal neurons to nerve growth factor

1988 • 323 citations

Distribution of Brain‐Derived Neurotrophic Factor in Rats and Its Changes with Development in the Brain

1997 • 291 citations

Degeneration and Sprouting of Identified Descending Supraspinal Axons after Contusive Spinal Cord Injury in the Rat

2001 • 291 citations

Chemotactic response of nerve fiber elongation to nerve growth factor

1978 • 279 citations

Activated Macrophage/Microglial Cells Can Promote the Regeneration of Sensory Axons into the Injured Spinal Cord

1997 • 268 citations

Sprouting and Regeneration of Lesioned Corticospinal Tract Fibres in the Adult Rat Spinal Cord

1993 • 260 citations

Versican Is Upregulated in CNS Injury and Is a Product of Oligodendrocyte Lineage Cells

2002 • 252 citations

Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth

1997 • 251 citations

NT‐3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord

1999 • 239 citations

Brain-Derived Neurotrophic Factor Stimulates Hindlimb Stepping and Sprouting of Cholinergic Fibers after Spinal Cord Injury

1998 • 218 citations

Development and growth of axonal sprouts from noradrenaline and 5-hydroxytryptamine neurones in the rat spinal cord

1971 • 218 citations

Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord

1994 • 213 citations

Evidence for regenerative axon sprouting of central catecholamine neurons in the rat mesencephalon following electrolytic lesions

1971 • 212 citations

Adrenal medullary autografts into the basal ganglia of Cebus monkeys: Injury-induced regeneration

1988 • 205 citations

The trkA Receptor Mediates Growth Cone Turning toward a Localized Source of Nerve Growth Factor

1997 • 193 citations

Lens-Injury-Stimulated Axonal Regeneration throughout the Optic Pathway of Adult Rats

2001 • 182 citations

Effects of silica on the outcome from experimental spinal cord injury: Implication of macrophages in secondary tissue damage

1994 • 175 citations

Induction of a neurite-promoting factor in rat brain following injury or deafferentation

1986 • 166 citations

Degeneration and Regeneration in the Nervous System

1991 • 162 citations

Putative chromaffin cell survival and enhanced host‐derived TH‐Fiber innervation following a functional adrenal medulla autograft for Parkinson's disease

1991 • 159 citations

Sprouts from Cut Corticospinal Axons Persist in the Presence of Astrocytic Scarring in Long-Term Lesions of the Adult Rat Spinal Cord

1995 • 154 citations

Chondroitinase ABC promotes axonal regeneration of Clarkeʼs neurons after spinal cord injury

2000 • 150 citations

Intracerebral transplantation in movement disorders

1992 • 146 citations

Does adrenal graft enhance recovery of dopaminergic neurons in Parkinson's disease?

1990 • 133 citations

Long-term evaluation of hemiparkinsonian monkeys after adrenal autografting or cavitation alone

1990 • 127 citations

Chapter 70 Transient behavioral recovery in hemiparkinsonian primates after adrenal medullary allografts

1988 • 124 citations

Fetal nondopaminergic neural implants in parkinsonian primates

1991 • 114 citations

Abortive regeneration of the transected spinal cord

1947 • 112 citations

Inhibition of brain‐derived neurotrophic factor and glial cell line‐derived neurotrophic factor expression reduces dopaminergic sprouting in the injured striatum

2000 • 106 citations

Improving axonal growth and functional recovery after experimental spinal cord injury by neutralizing myelin associated inhibitors

2001 • 105 citations

The chondroitin sulphate proteoglycan brevican is upregulated by astrocytes after entorhinal cortex lesions in adult rats

2000 • 102 citations

Relationship between sprouting axons, proteoglycans and glial cells following unilateral nigrostriatal axotomy in the adult rat

2002 • 97 citations

Sensory neurite growth cone guidance by substrate adsorbed nerve growth factor

1985 • 91 citations

The effect of microglia on embryonic dopaminergic neuronal survival in vitro: diffusible signals from neurons and glia change microglia from neurotoxic to neuroprotective

1999 • 84 citations

Neuroprotective effects of brain-derived neurotrophic factor in seizures during development

1999 • 76 citations

Beyond the Glial Scar

1999 • 69 citations

CNS regeneration : basic science and clinical advances

2008 • 69 citations

Robust Regeneration of CNS Axons through a Track Depleted of CNS Glia

2000 • 63 citations

Alterations in neurofilaments associated with reactive brain changes and axonal sprouting following acute physical injury to the rat neocortex

2001 • 62 citations

Relationship between injury-induced astrogliosis, laminin expression and axonal sprouting in the adult rat brain

1994 • 53 citations

Expression of Brain-Derived Neurotrophic Factor and TrkB Neurotrophin Receptors after Striatal Injury in the Mouse

1997 • 47 citations

Expression of glial cell line-derived neurotrophic factor (GDNF) mRNA following mechanical injury to mouse striatum

1997 • 46 citations

Reversal of hemiparkinsonian syndrome in nonhuman primates by amnion implantation into caudate nucleus

1994 • 44 citations

Regenerative and other responses to injury in the retinal stump of the optic nerve in adult albino rats: transection of the intraorbital optic nerve.

1994 • 43 citations

Sprouting of Dopaminergic Axons after Striatal Injury: Confirmation by Markers Not Dependent on Dopamine Metabolism

1999 • 42 citations

Recovery in hemiparkinsonian rats following intrastriatal implantation of activated leukocytes

1992 • 31 citations

Xenogeneic Adrenal Medulla Graft Rejection Rather Than Survival Leads to Increased Rat Striatal Tyrosine Hydroxylase Immunoreactivity

1997 • 24 citations

Traumatized Rat Striatum Produces Neurite-Promoting and Neurotrophic Activitiesin Vitro

1996 • 21 citations

Fate of Severed Cortical Projection Axons

1993 • 20 citations

Axon-glial relations during regeneration of axons in the adult rat anterior medullary velum.

1998 • 18 citations

Trauma-induced striatal CNTF and BDNF mRNA in hemiparkinsonian rats

1997 • 14 citations

Paraventriculospinal tract as a model for axon injury: Spinal cord

1994 • 13 citations

Periwound dopaminergic sprouting is dependent on numbers of wound macrophages

2002 • 12 citations

Identified central axons differ in their response to spinal cord transection

1984 • 10 citations

Inflammation and the glial scar

2010 • 8 citations

Intrinsic neuronal and extrinsic glial determinants of axonal regeneration in the injured spinal cord

2000 • 4 citations