Glycogen Synthase Kinase 3β Is a Natural Activator of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase Kinase 1 (MEKK1)

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

1999 • 1,593 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

2000 • 1,365 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

1996 • 1,299 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

1998 • 1,049 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

2000 • 783 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1

2001 • 700 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Akt Signaling--Linking Membrane Events to Life and Death Decisions

1997 • 504 citations

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1999 • 459 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

Role of Glycogen Synthase Kinase-3β in Neuronal Apoptosis Induced by Trophic Withdrawal

2000 • 440 citations

Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1

1999 • 409 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

1998 • 329 citations

Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase

2001 • 321 citations

Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization

1999 • 267 citations

Further evidence that the inhibition of glycogen synthase kinase‐3β by IGF‐1 is mediated by PDK1/PKB‐induced phosphorylation of Ser‐9 and not by dephosphorylation of Tyr‐216

1997 • 232 citations

GSK3, a master switch regulating cell-fate specification and tumorigenesis

2000 • 219 citations

c-Jun NH2-terminal Kinase-mediated Activation of Interleukin-1β Converting Enzyme/CED-3-like Protease during Anticancer Drug-induced Apoptosis

1997 • 207 citations

Akt (Protein Kinase B) Negatively Regulates SEK1 by Means of Protein Phosphorylation

2002 • 142 citations

The TAO of MEKK

1998 • 132 citations

Axin Forms a Complex with MEKK1 and Activates c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase through Domains Distinct from Wnt Signaling

1999 • 128 citations

GSK-3: New Thoughts on an Old Enzyme

2000 • 112 citations

Glycogen Synthase Kinase 3β Is Tyrosine Phosphorylated by PYK2

2001 • 110 citations

APC: the plot thickens

1999 • 97 citations

Insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase

1998 • 85 citations

Akt negatively regulates the cJun N-terminal kinase pathway in PC12 cells

2000 • 69 citations

Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation

1998 • 48 citations

Dimerization Choices Control the Ability of Axin and Dishevelled to Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase

2000 • 44 citations

Insulin Receptor Substrate-2 Phosphorylation Is Necessary for Protein Kinase Cζ Activation by Insulin in L6hIR Cells

2001 • 41 citations

Role of Receptor-interacting Protein in Tumor Necrosis Factor-α-dependent MEKK1 Activation

2001 • 32 citations

Negative Regulation of the Sapk/Jnk Signaling Pathway by Presenilin 1

2001 • 30 citations