T cells in amyotrophic lateral sclerosis

A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

2007 • 1,359 citations

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

2006 • 1,130 citations

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

1999 • 881 citations

Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells

2005 • 867 citations

T-cell subsets (Th1 versus Th2)

2000 • 805 citations

What is immune privilege (not)?

2006 • 708 citations

Natural regulatory T cells: mechanisms of suppression

2007 • 704 citations

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.

1992 • 531 citations

Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue

2003 • 519 citations

The window of therapeutic opportunity in multiple sclerosis

2005 • 497 citations

Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases

2002 • 471 citations

Inflammatory processes in amyotrophic lateral sclerosis

2002 • 460 citations

Induction of MHC Class I Genes in Neurons

1995 • 446 citations

Immune reactivity in a mouse model of familial ALS correlates with disease progression

2001 • 424 citations

Expression of the histocompatibility glycoprotein HLA-DR in neurological disease

1988 • 397 citations

Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson’s disease

2007 • 386 citations

Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation

1991 • 362 citations

A two-step, two-signal model for the primary activation of precursor helper T cells

1999 • 356 citations

Cytokines, chemokines, and cytokine receptors in human microglia

2002 • 341 citations

Neuroprotective role of the innate immune system by microglia

2007 • 339 citations

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes

2007 • 322 citations

Control of glial immune function by neurons

2001 • 315 citations

Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis

1993 • 295 citations

Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: Implications for glaucoma

2001 • 293 citations

Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system.

1990 • 240 citations

Whole-Genome Analysis of Sporadic Amyotrophic Lateral Sclerosis

2007 • 240 citations

Neuronal Damage in Brain Inflammation

2007 • 231 citations

Neuronal Survival after CNS Insult Is Determined by a Genetically Encoded Autoimmune Response

2001 • 231 citations

Neuronal Damage in Autoimmune Neuroinflammation Mediated by the Death Ligand TRAIL

2005 • 212 citations

Protective autoimmunity: interferon‐γ enables microglia to remove glutamate without evoking inflammatory mediators

2005 • 207 citations

Therapeutic vaccine for acute and chronic motor neuron diseases: Implications for amyotrophic lateral sclerosis

2003 • 201 citations

Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells

2004 • 199 citations

Dual effect of CD4⁺CD25⁺regulatory T cells in neurodegeneration: A dialogue with microglia

2004 • 159 citations

Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)

2004 • 150 citations

Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases

1998 • 148 citations

Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis

1990 • 142 citations

Direct Impact of T Cells on Neurons Revealed by Two-Photon Microscopy in Living Brain Tissue

2004 • 142 citations

Glatiramer Acetate: Mechanisms of Action in Multiple Sclerosis

2007 • 136 citations

Elevated IL-6 and TNF-α levels in patients with ALS: Inflammation or hypoxia?

2005 • 128 citations

Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis

1990 • 125 citations

Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment

2006 • 118 citations

Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7–2 (CD86) and prevention of cyst formation

2001 • 111 citations

Identification of the inflammatory cells in the central nervous system of patients with adrenoleukodystrophy

1985 • 105 citations

Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis.

1989 • 97 citations

CD4+ T cells from Copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

2006 • 92 citations

TRANSFORMING GROWTH FACTOR-BETA 1 (TGF-BETA 1) IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS

2002 • 92 citations

Immune-mediated neuroprotection of axotomized mouse facial motoneurons is dependent on the IL-4/STAT6 signaling pathway in CD4+ T cells

2006 • 66 citations

Increased IL-13-producing T cells in ALS: Positive correlations with disease severity and progression rate

2006 • 65 citations

CEREBROSPINAL FLUID AND SERUM PROTEIN LEVELS OF TUMOUR NECROSIS FACTOR-ALPHA (TNF-α), INTERLEUKIN-6 (IL-6) AND SOLUBLE INTERLEUKIN-6 RECEPTOR (sIL-6R gp80) IN MULTIPLE SCLEROSIS PATIENTS

2002 • 57 citations

Lymphocyte targeting of the brain in adoptive transfer cryolesion-EAE

1999 • 56 citations

Cellular Immunity in Guamanians with Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia

1978 • 49 citations

Randomized controlled phase II trial of glatiramer acetate in ALS

2006 • 48 citations

Breaking Ignorance: The Case of the Brain

2006 • 48 citations

RANTES levels are elevated in serum and cerebrospinal fluid in patients with amyotrophic lateral sclerosis

2007 • 48 citations

Brain-derived neurotrophic factor supports facial motoneuron survival after facial nerve transection in immunodeficient mice

2004 • 45 citations

Neurotrophic cross-talk between the nervous and immune systems: Relevance for repair strategies in multiple sclerosis?

2007 • 42 citations

Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS

2006 • 42 citations

Lymphocyte infiltration in the injured brain: Role of proinflammatory cytokines

2003 • 40 citations

T Cell Receptor BV Gene Rearrangements in the Spinal Cords and Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis

1999 • 29 citations

Limited effects of glatiramer acetate in the high-copy number hSOD1-G93A mouse model of ALS

2007 • 23 citations

ALS: Cytokine profile in cerebrospinal fluid T‐cell clones

2006 • 18 citations

Interleukin‐12 and interferon‐γ are not detectable in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis

2004 • 14 citations

T lymphocytes in peripheral blood from patients with neurological diseases

2009 • 13 citations

Strategies for axonal repair in central nervous system diseases

2007 • 8 citations

T-cell receptor Vβ gene usage in CSF lymphocytes in X-linked adrenoleukodystrophy

2004 • 6 citations