Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells

Inflammation and Alzheimer's disease

2000 • 4,315 citations

Leukotrienes and Other Products of the 5-Lipoxygenase Pathway

1990 • 1,216 citations

Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin

1990 • 975 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.

1992 • 531 citations

Immune reactivity in a mouse model of familial ALS correlates with disease progression

2001 • 424 citations

Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues

2001 • 423 citations

The importance of inflammatory mechanisms in alzheimer disease

1998 • 325 citations

Glutamate Transporters in Neurologic Disease

2001 • 324 citations

Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS

2002 • 305 citations

Cyclooxygenase‐2‐positive macrophages infiltrate the Alzheimer’s disease brain and damage the blood–brain barrier

2002 • 287 citations

Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis

2001 • 270 citations

Activation of human B lymphocytes through CD40 and interleukin 4

1989 • 227 citations

Inducible Nitric Oxide Synthase Up‐Regulation in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1999 • 224 citations

Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model.

1998 • 223 citations

Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis

2001 • 182 citations

Upregulation and interaction of TNFα and gelatinases A and B in painful peripheral nerve injury

2000 • 170 citations

Marked increase in cyclooxygenase-2 in ALS spinal cord

2001 • 146 citations

Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients

2002 • 143 citations

Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease

2002 • 136 citations

Mast Cell-Nerve Interactions

2000 • 129 citations

Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions

1997 • 121 citations

Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis

2000 • 113 citations

Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways

2002 • 111 citations

Mast cells differentially express and release active high molecular weight neurotrophins

2001 • 95 citations

Function and Regulation of Prostaglandin Synthase 2

1999 • 94 citations

Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis

2003 • 79 citations

CD40 ligand‐positive CD8⁺ T cell clones allow B cell growth and differentiation

1995 • 74 citations

Function and Regulation of Prostaglandin Synthase-2

1997 • 63 citations

Mast Cell Activation Causes Delayed Neurodegeneration in Mixed Hippocampal Cultures via the Nitric Oxide Pathway

1996 • 59 citations

Aggregate Formation in Cu,Zn Superoxide Dismutase-related Proteins

2003 • 43 citations

Therapeutic developments in the treatment of amyotrophic lateral sclerosis

2002 • 24 citations

Mast cell specific proteases in rat brain: changes in rats with experimental allergic encephalomyelitis

1997 • 24 citations

Mast cells in Wallerian degeneration: Morphologic and ultrastructural changes

2002 • 21 citations

Pathological study of the diffuse myelin pallor in the anterolateral columns of the spinal cord in amyotrophic lateral sclerosis

2001 • 19 citations

Induction of cyclooxygenase-2 and enhanced release of prostaglandin E2 and I2 in human endothelial cells by engagement of CD40

2002 • 15 citations

Changes in mast‐cell distribution in skeletal muscle after denervation

1992 • 5 citations