Cell-free tumor antigen peptide-based cancer vaccines

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684.

1996 • 2,073 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

1994 • 921 citations

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

1994 • 850 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Transferrin-polycation conjugates as carriers for DNA uptake into cells.

1990 • 657 citations

High Efficiency DNA-Mediated Transformation of Primate Cells

1983 • 652 citations

Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes.

1994 • 584 citations

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

1992 • 483 citations

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

1994 • 421 citations

Paracrine Cytokine Adjuvants in Cancer Immunotherapy

1995 • 373 citations

Chemistry of peptides associated with MHC class I and class II molecules

1995 • 371 citations

Mechanisms of antigen uptake for presentation

1996 • 354 citations

Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.

1996 • 290 citations

Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes.

1995 • 282 citations

Functional analysis of alternatively spliced tyrosinase gene transcripts.

1988 • 275 citations

MHC Class I–Restricted CTL Responses to Exogenous Antigens

1996 • 265 citations

Recombinant Interferon Alfa-2b Combined with a Regimen Containing Doxorubicin in Patients with Advanced Follicular Lymphoma

1993 • 263 citations

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck

1997 • 259 citations

Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy.

1994 • 247 citations

Cloning and expression of cDNA encoding mouse tyrosinase

1986 • 241 citations

Genes Coding for Tumor Antigens Recognized by Cytolytic T Lymphocytes

1995 • 233 citations

T cell priming versus T cell tolerance induced by synthetic peptides.

1995 • 230 citations

Naturally-occurring peptide antigens derived from the MHC class-I-restricted processing pathway

1991 • 171 citations

MHC molecules as peptide receptors

1993 • 169 citations

Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides

1995 • 162 citations

Toward a Genetic Analysis of Tumor Rejection Antigens

1992 • 151 citations

Specific release of granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and IFN-gamma by human tumor-infiltrating lymphocytes after autologous tumor stimulation.

1991 • 138 citations

Differential effects of interleukin‐12 on the development of naive mouse CD4⁺ T cells

1994 • 132 citations

Cancer vaccines: the interleukin 2 dosage effect.

1995 • 127 citations

Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.

1994 • 126 citations

Antineoplastic activity of poly(L-lysine) with some ascites tumor cells.

1979 • 117 citations

Priming of tumor-specific T cells in the draining lymph nodes after immunization with interleukin 2-secreting tumor cells: three consecutive stages may be required for successful tumor vaccination.

1995 • 94 citations

Elicitation of a systemic and protective anti-melanoma immune response by an IL-2-based vaccine. Assessment of critical cellular and molecular parameters.

1995 • 88 citations

The role of IL-2 secreted from genetically modified tumor cells in the establishment of antitumor immunity.

1994 • 85 citations

Cytokine Gene Therapy with Interleukin-2-Transduced Fibroblasts: Effects of IL-2 Dose on Anti-Tumor Immunity

1995 • 83 citations

New tumor antigens recognized by T cells

1995 • 61 citations

Transloading of tumor antigen-derived peptides into antigen-presenting cells

1997 • 51 citations

Making Headway against Cancer

1996 • 42 citations

Somatic gene therapy for cancer: the utility of transferrinfection in generating ‘tumor vaccines’

1993 • 35 citations

Transloading of tumor cells with foreign major histocompatibility complex class I peptide ligand: a novel general strategy for the generation of potent cancer vaccines.

1996 • 18 citations

A prominent natural H-2 Kd ligand is derived from protein tyrosine kinase JAK1

1993 • 15 citations

Generation of effective cancer vaccines genetically engineered to secrete cytokines using adenovirus-enhanced transferrinfection (AVET)

1997 • 13 citations

The Changing Quality of Life

1996 • 4 citations

Accelerated tumor development in interferon-treated B6.C-Hyal-1 a mice.

1993 • 2 citations