Recent Highlights in the Pathophysiology of Atopic Eczema

Atopic Dermatitis

2000 • 4,717 citations

Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003

2004 • 2,230 citations

New insights into atopic dermatitis

2004 • 1,368 citations

Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.

1994 • 780 citations

Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity

2001 • 541 citations

Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens.

1993 • 525 citations

CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells

1999 • 502 citations

Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI).

1992 • 490 citations

Plasmacytoid Dendritic Cells: A New Cutaneous Dendritic Cell Subset with Distinct Role in Inflammatory Skin Diseases

2002 • 450 citations

Allergic and nonallergic forms of atopic diseases

2003 • 437 citations

Immunomorphological and Ultrastructural Characterization of Langerhans Cells and a Novel, Inflammatory Dendritic Epidermal Cell (IDEC) Population in Lesional Skin of Atopic Eczema

1996 • 404 citations

Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis

1992 • 388 citations

Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci

2001 • 386 citations

In vivo expression of IL-12 and IL-13 in atopic dermatitis

1996 • 380 citations

Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions

2003 • 308 citations

T regulatory cells in atopic dermatitis and subversion of their activity by superantigens

2004 • 307 citations

The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study

2004 • 275 citations

A major susceptibility locus for atopic dermatitis maps to chromosome 3q21

2000 • 266 citations

Exposure to endotoxin decreases the risk of atopic eczema in infancy: A cohort study

2001 • 249 citations

A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children☆

2004 • 230 citations

Enhanced Expression of Eotaxin and CCR3 in Atopic Dermatitis

1999 • 217 citations

Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.

1998 • 215 citations

FcεRI engagement of Langerhans cell–like dendritic cells and inflammatory dendritic epidermal cell–like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro☆

2004 • 186 citations

T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells

2003 • 182 citations

Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB)

2000 • 164 citations

Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor

1998 • 163 citations

Characterization of FcεRI-bearing CD123+ blood dendritic cell antigen-2+ plasmacytoid dendritic cells in atopic dermatitis

2004 • 145 citations

Toll-like receptor 4 polymorphism and severity of atopy in asthmatics

2004 • 143 citations

Immunoglobulin E Response to Human Proteins in Atopic Patients

1996 • 140 citations

Atopy patch test reactions show a rapid influx of inflammatory dendritic epidermal cells in patients with extrinsic atopic dermatitis and patients with intrinsic atopic dermatitis

2003 • 138 citations

Molecular Characterization of an Autoallergen, Hom s 1, Identified by Serum IgE from Atopic Dermatitis Patients11Part of this manuscript was previously published in the proceedings of the 21st Symposium of the Collegium Internationale Allergologicum “Allergy – A Disease of Modern Society”, Int Arch Allergy Immunol 113:209–212, 1998

1998 • 135 citations

Dichotomic Nature of Atopic Dermatitis Reflected by Combined Analysis of Monocyte Immunophenotyping and Single Nucleotide Polymorphisms of the Interleukin-4/Interleukin-13 Receptor Gene: The Dichotomy of Extrinsic and Intrinsic Atopic Dermatitis

2002 • 135 citations

Atopic dermatitis is associated with a low-producer transforming growth factor β1 cytokine genotype

2001 • 119 citations

CC Chemokine Ligand 18, An Atopic Dermatitis-Associated and Dendritic Cell-Derived Chemokine, Is Regulated by Staphylococcal Products and Allergen Exposure

2004 • 115 citations

Macrophage-derived chemokine production by activated human T cellsin vitro andin vivo: preferential association with the production of type 2 cytokines

2000 • 111 citations

Identifying genes predisposing to atopic eczema☆☆☆★★★

1999 • 105 citations

Clinical and immunologic variables in skin of patients with atopic eczema and either positive or negative atopy patch test reactions

2000 • 97 citations

Surface expression of FcϵRI on Langerhans' cells of clinically uninvolved skin is associated with disease activity in atopic dermatitis, allergic asthma, and rhinitis

2003 • 59 citations

Expression of IL-18 mRNA and secretion of IL-18 are reduced in monocytes from patients with atopic dermatitis

2001 • 57 citations

In vivo expression of cytokine receptor mRNA in atopic dermatitis

1998 • 55 citations

Evidence for a role of Langerhans cell-derived IL-16 in atopic dermatitis

2002 • 52 citations

A Reducing Microenvironment Leads to the Generation of FcεRIhigh Inflammatory Dendritic Epidermal Cells (IDEC)

2002 • 42 citations

Decreased IL-15 May Contribute to Elevated IgE and Acute Inflammation in Atopic Dermatitis

2002 • 40 citations

Characterization of IgE–Reactive Autoantigens in Atopic Dermatitis 1. Subcellular Distribution and Tissue–Specific Expression

1999 • 34 citations

Enhanced Production of RANTES, an Eosinophil Chemoattractant Factor, by Cytokine-Stimulated Epidermal Keratinocytes

1997 • 34 citations

Transforming Growth Factor-β1 Regulates the Expression of the High-Affinity Receptor for IgE on CD34+ Stem Cell-Derived CD1a+ Dendritic Cells In Vitro

2004 • 25 citations