Synthesis of Prostaglandin E2 Ethanolamide from Anandamide by Cyclooxygenase-2

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1994 • 1,263 citations

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

1996 • 618 citations

On the Mechanism of the Biosynthesis of Prostaglandins E1 and F1α

1967 • 403 citations

Regulation of fibroblast cyclooxygenase synthesis by interleukin-1.

1988 • 401 citations

The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.

1994 • 383 citations

Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes

1997 • 372 citations

Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

1994 • 339 citations

Partial Purification and Characterization of the Porcine Brain Enzyme Hydrolyzing and Synthesizing Anandamide

1995 • 305 citations

Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2

1995 • 294 citations

Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents

1993 • 237 citations

Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells.

1992 • 191 citations

Cannabinoid Receptors Are Coupled to Nitric Oxide Release in Invertebrate Immunocytes, Microglia, and Human Monocytes

1996 • 187 citations

Involvement of Arginine 120, Glutamate 524, and Tyrosine 355 in the Binding of Arachidonate and 2-Phenylpropionic Acid Inhibitors to the Cyclooxygenase Active Site of Ovine Prostaglandin Endoperoxide H Synthase-1

1996 • 178 citations

Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis

1994 • 174 citations

The N-acylation-phosphodiesterase pathway and cell signalling

1996 • 157 citations

Arginine 120 of Prostaglandin G/H Synthase-1 Is Required for the Inhibition by Nonsteroidal Anti-inflammatory Drugs Containing a Carboxylic Acid Moiety

1995 • 140 citations

(—)-Δ9-Tetrahydrocannabinol Antagonizes the Peripheral Cannabinoid Receptor-mediated Inhibition of Adenylyl Cyclase

1996 • 140 citations

Anandamide hydroxylation by brain lipoxygenase:metabolite structures and potencies at the cannabinoid receptor

1995 • 130 citations

Differential Inhibition of RAW264.7 Macrophage Tumoricidal Activity by 9Tetrahydrocannabinol

1995 • 47 citations

Correction: Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

1997 • 12 citations