Electrostatic interactions in wild-type and mutant recombinant human myoglobins

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Savitzky-Golay Smoothing Filters

1990 • 11,997 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

NMR of Proteins and Nucleic Acids

2006 • 5,989 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins

1983 • 3,150 citations

A two-dimensional nuclear overhauser experiment with pure absorption phase in four quadrants

1982 • 2,567 citations

Improved spectral resolution in COSY 1H NMR spectra of proteins via double quantum filtering

1983 • 2,327 citations

The chemist's companion

1973 • 1,779 citations

Cleavage of the haem-protein link by acid methylethylketone

1959 • 1,226 citations

Calculations of electrostatic interactions in biological systems and in solutions

1984 • 992 citations

Calculation of the electric potential in the active site cleft due to α-helix dipoles

1982 • 931 citations

Affinities of amino acid side chains for solvent water

1981 • 846 citations

Structure of myoglobin refined at 2·0 Å resolution

1977 • 676 citations

Determination of Nucleotide Sequences in DNA

1981 • 593 citations

Generation of β-globin by sequence-specific proteolysis of a hybrid protein produced in Escherichia coli

1984 • 374 citations

Quantitative Chemical Analysis

1873 • 359 citations

Origin of the heme Cotton effects in myoglobin and hemoglobin

1971 • 339 citations

On the calculation of electrostatic interactions in proteins

1985 • 331 citations

Rational modification of enzyme catalysis by engineering surface charge

1987 • 321 citations

Electrostatic Effects in Proteins

1985 • 310 citations

Aspartic acid substitutions affect proton translocation by bacteriorhodopsin.

1988 • 282 citations

Energetics of charge–charge interactions in proteins

1988 • 279 citations

Visual-pigment spectra: implications of the protonation of the retinal Schiff base

1976 • 236 citations

Purification of Calf Prochymosin (Prorennin) Synthesized in Escherichia Coli

1984 • 227 citations

Experimental evaluation of the effective dielectric constant of proteins

1980 • 223 citations

Secondary structure of the α-amylase polypeptide inhibitor Tendamistat from Streptomyces tendae determined in solution by 1H nuclear magnetic resonance

1985 • 200 citations

Effects of Buried Ionizable Amino Acids on the Reduction Potential of Recombinant Myoglobin

1989 • 163 citations

Determining globular protein stability: guanidine hydrochloride denaturation of myoglobin

1979 • 157 citations

Proton nuclear magnetic resonance characterization of heme disorder in hemoproteins.

1978 • 144 citations

The ionization of acidic metmyoglobin

1952 • 114 citations

Cloning, expression in Escherichia coli, and reconstitution of human myoglobin.

1985 • 111 citations

Charged amino acids as spectroscopic determinants for chlorophyll in vivo

1983 • 110 citations

Nuclear magnetic resonance determination of ligand-induced conformational changes in myoglobin

1970 • 92 citations

Assignment of resonances in the 1H nuclear magnetic resonance spectrum of the carbon monoxide complex of sperm whale myoglobin by phase-sensitive two-dimensional techniques

1987 • 84 citations

Structure and Subunit Interaction of Haemoglobin M Milwaukee

1972 • 81 citations

Idiopathic Heinz Body Anaemia: Hb‐Bristol (β67 (E11) Val→Asp)

1970 • 78 citations

X-ray crystallographic studies of seal myoglobin: The molecule at 6 Å and 5 Å resolution

1969 • 65 citations

Assignment of heme and distal amino acid resonances in the 1H-NMR spectra of the carbon monoxide and oxygen complexes of sperm whale myoglobin

1985 • 62 citations

Solution properties of synthetic chlorophyllide- and bacteriochlorophyllide-apomyoglobin complexes

1981 • 49 citations

X-ray crystallographic studies of seal myoglobin

1978 • 40 citations

Molecular charge and electrophoretic mobility in cetacean myoglobins of known sequence

1984 • 39 citations

Preparation and properties of a chlorophyllide-apomyoglobin complex

1979 • 35 citations

Functional design of heme proteins: reaction with linear liqands

1980 • 25 citations

Heme orientation in the major monomeric hemoglobins of Glycera dibranchiata

1985 • 24 citations

Heme orientational heterogeneity in deuterohemin-reconstituted horse and human hemoglobin characterized by proton nuclear magnetic resonance spectroscopy

1984 • 24 citations