Mechanisms by which extracellular ATP and UTP stimulate the release of prostacyclin from bovine pulmonary artery endothelial cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Amino Acid Metabolism in Mammalian Cell Cultures

1959 • 4,025 citations

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

Extracellular ATP: effects, sources and fate

1986 • 1,666 citations

Advances in Cyclic Nucleotide Research.

1980 • 1,465 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls

1979 • 1,158 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

The chemical structure of prostaglandin X (prostacyclin)

1976 • 729 citations

Role of phospholipases in generating lipid second messengers in signal transduction ¹

1991 • 545 citations

Characterization of ionomycin as a calcium ionophore.

1978 • 535 citations

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

1988 • 512 citations

Physiological roles for adenosine and adenosine 5′-triphosphate in the nervous system

1981 • 484 citations

Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate.

1985 • 430 citations

Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries.

1981 • 380 citations

Further subclassification of ATP receptors based on agonist studies

1991 • 374 citations

PHARMACOLOGICAL REGULATION OF CALMODULIN*

1980 • 341 citations

Calmodulin stimulates human platelet phospholipase A2

1979 • 309 citations

Correlation between thrombin-induced prostacyclin production and inositol trisphosphate and cytosolic free calcium levels in cultured human endothelial cells.

1987 • 281 citations

Source and concentration of extracellular adenosine triphosphate during haemostasis in rats, rabbits and man.

1984 • 267 citations

THE DISTRIBUTION AND METABOLISM OF ARACHIDONIC ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGS

1977 • 264 citations

Stimulation of Prostaglandin Biosynthesis by Adenine Nucleotides

1974 • 211 citations

Involvement of inositol 1,4,5-trisphosphate and calcium in the action of adenine nucleotides on aortic endothelial cells.

1987 • 202 citations

Exogenous ATP raises cytoplasmic free calcium in fura‐2 loaded piglet aortic endothelial cells

1986 • 200 citations

Thrombin-stimulated elevation of human endothelial-cell cytoplasmic free calcium concentration causes prostacyclin production

1988 • 190 citations

Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms.

1988 • 189 citations

Activation of phospholipases A2 and C in pig aortic endothelial cells synthesizing prostacyclin.

1982 • 182 citations

P2-Purinergic Agonists Stimulate Phosphodiesteratic Cleavage of Phosphatidylcholine in Endothelial Cells

1989 • 180 citations

The hydrolysis of extracellular adenine nucleotides by cultured endothelial cells from pig aorta. Feed-forward inhibition of adenosine production at the cell surface.

1986 • 176 citations

Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides

1989 • 172 citations

Increased free calcium in endothelial cells under stimulation with adenine nucleotides

1986 • 171 citations

Stimulation of prostaglandin production through purinoceptors on cultured porcine endothelial cells

1983 • 170 citations

Prostacyclin modulates cholesteryl ester hydrolytic activity by its effect on cyclic adenosine monophosphate in rabbit aortic smooth muscle cells.

1982 • 170 citations

Prostacyclin and arterial wall biology.

1982 • 164 citations

A simple, sensitive, and specific radioreceptor assay for inositol 1,4,5-trisphosphate in biological tissues

1989 • 164 citations

Nucleotide Metabolism by Endothelium

1985 • 164 citations

P2 purinoceptors on vascular endotheliai cells: physiological significance and transduction mechanisms

1990 • 160 citations

Intracellular Ca2+ mobilization activated by extracellular ATP in Ehrlich ascites tumor cells.

1985 • 159 citations

Identification and purification of sheep platelet phospholipase A2 isoforms. Activation by physiologic concentrations of calcium ion.

1986 • 147 citations

Characteristics of the P2 purinoceptor that mediates prostacyclin production by pig aortic endothelial cells

1987 • 145 citations

Regulation of P_2y‐purinoceptor‐mediated prostacyclin release from human endothelial cells by cytoplasmic calcium concentration

1988 • 142 citations

Prostaglandins, Leukotrienes and lipoxins

1986 • 111 citations

Mechanism of bradykinin-stimulated prostacyclin synthesis in porcine aortic endothelial cells

1982 • 100 citations

Guanine Nucleotide-sensitive Interaction of a Radiolabeled Agonist with a Phospholipase C-linked P2y-purinergic Receptor

1989 • 98 citations

Extracellular nucleotides stimulate receptor-mediated calcium mobilization and inositol phosphate production in human fibroblasts

1989 • 95 citations

Stimulation of vascular prostacyclin synthesis by extracellular ADP and ATP

1983 • 83 citations

Uptake of extracellular Ca²⁺ and not recruitment from internal stores is essential for T lymphocyte proliferation

1988 • 72 citations

Studies on the increase in cytosolic free calcium induced by epidermal growth factor, serum, and nucleotides in individual A431 cells

1988 • 68 citations

Stimulation by ATP of Inositol Trisphosphate Accumulation and Calcium Mobilization in Cultured Adrenal Chromaffin Cells

1989 • 67 citations

Prostacyclin synthesis and deacylation of phospholipids in human endothelial cells: Comparison of thrombin, histamine and ionophore A23187

1985 • 66 citations

Covalent incorporation of 3'-O-(4-benzoyl)benzoyl-ATP into a P2 purinoceptor in transformed mouse fibroblasts.

1990 • 55 citations

Distribution of phospholipids, fatty acids, and platelet factor 3 activity among subcellular fractions of human platelets

1976 • 48 citations

Phosphatidylcholine is the major phospholipid providing arachidonic acid for prostacyclin synthesis in thrombin-stimulated human endothelial cells

1984 • 43 citations

Role of Ca2+ in H+ transport by rabbit gastric glands studied with A23187 and BAPTA, an incorporated Ca2+ chelator

1989 • 36 citations

Purinergic vs peptidergic stimulation of lipolysis and prostaglandin generation in the perfused rabbit kidney

1982 • 19 citations

Ethanol alters the transfer of arachidonic acid to ethanolamine plasmalogens in C‐6 glioma cells

1989 • 7 citations

Effects of quinacrine on vasopressin-induced changes in glycogen phosphorylase activity, Ca2+ transport and phosphoinositide metabolism in isolated hepatocytes

1988 • 5 citations