Nucleotide sequence of the dihydrofolate reductase gene of Saccharomyces cerevisiae

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Methods in yeast genetics

1979 • 7,824 citations

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

Methods in Yeast Genetics

1988 • 4,905 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

1984 • 4,231 citations

The 3′-Terminal Sequence of Escherichia coli 16S Ribosomal RNA: Complementarity to Nonsense Triplets and Ribosome Binding Sites

1974 • 3,603 citations

A system for shotgun DNA sequencing

1981 • 2,710 citations

Transformation of yeast.

1978 • 2,267 citations

Compilation and analysis ofEscherichia colipromoter DNA sequences

1983 • 2,228 citations

Codon selection in yeast.

1982 • 1,580 citations

DNA sequence required for efficient transcription termination in yeast

1982 • 1,014 citations

Sterile host yeasts (SHY): A eukaryotic system of biological containment for recombinant DNA experiments

1979 • 967 citations

Conservation of high efficiency promoter sequences inSaccharomyces cerevisiae

1982 • 418 citations

Nucleotide sequence of the E. coli gene coding for dihydrofolate reductase

1980 • 378 citations

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

1984 • 339 citations

On the antiquity of introns

1986 • 324 citations

Dihydrofolate Reductase: X-ray Structure of the Binary Complex with Methotrexate

1977 • 323 citations

Targeted selection of recombinant clones through gene dosage effects.

1983 • 262 citations

Genome comparison in yeast systematics: delimitation of species within the genera Schwanniomyces, Saccharomyces, Debaryomyces, and Pichia

1978 • 248 citations

The functional human dihydrofolate reductase gene.

1984 • 245 citations

Crystal structure of avian dihydrofolate reductase containing phenyltriazine and NADPH.

1982 • 219 citations

Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells.

1982 • 184 citations

Transcription terminates in yeast distal to a control sequence

1983 • 181 citations

Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major.

1986 • 165 citations

Plasmids pEMBLY: new single-stranded shuttle vectors for the recovery and analysis of yeast DNA sequences

1985 • 157 citations

A catenated DNA molecule as an intermediate in the replication of the resistance transfer factor R6K in Escherichia coli

1973 • 149 citations

A small-scale five-hour procedure for isolating multiple samples of CsCl-purified DNA: Application to isolations from mammalian, insect, higher plant, algal, yeast, and bacterial sources

1986 • 140 citations

The nucleotide sequence of the trimethoprim-resistant dihydrofolate reductase gene harbored by Tn7

1983 • 111 citations

The nucleotide sequence of the yeast ARG4 gene

1984 • 109 citations

Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins.

1986 • 92 citations

Monitoring of plasmid-encoded, trimethoprim-resistant dihydrofolate reductase genes: detection of a new resistant enzyme

1982 • 74 citations

The RAD2 gene of Saccharomyces cerevisiae: nucleotide sequence and transcript mapping

1985 • 45 citations

Cloning of the Escherichia coli K-12 dihydrofolate reductase gene following Mu-mediated transposition

1980 • 39 citations

Mapping and sequencing of the dihydrofolate reductase gene (DFR1) of Saccharomyces cerevisiae

1988 • 37 citations

Cloning of a yeast dihydrofolate reductase gene in Escherichia coli

1984 • 13 citations

Kinetics of methotrexate binding to dihydrofolate reductase from Neisseria gonorrhoeae

1984 • 5 citations